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Human vaccinia virus immune globulin
go.drugbank.com/drugs/DB14112ApprovedInvestigationalHuman vaccinia immune globulin (VIG) is a sterile solution containing the purified gamma globulin (IgG) fraction of plasma taken from healthy donors previously vaccinated with live vaccinia virus vaccine … Most compounds used currently are intravenous formulations, which contain no preservatives - unlike prior intramuscular compounds which contained thiomersal, a mercury derivative preservative that could
Categories: Immunoglobulin G, Human Immunoglobulin GMepolizumab
go.drugbank.com/drugs/DB06612ApprovedInvestigationalEosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm<sup>3</sup> or more) is associated with a spectrum … The pathogenesis of eosinophilia is complex, but IL-5 is recognized as a key cytokine involved in the differentiation, recruitment, activation, and prolonged survival of eosinophils in peripheral tissue
Categories: Interleukin-5 AntagonistProducts: NUCALA® 100MG/ML SOLUCION INYECTABLE, Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör (1 adet)Pexidartinib
go.drugbank.com/drugs/DB12978ApprovedInvestigationalPexidartinib is a selective tyrosine kinase inhibitor that works by inhibiting the colony-stimulating factor (CSF1)/CSF1 receptor pathway. … [A182240,L7901] Debilitating symptoms often follow with tenosynovial giant cell tumors, along with a risk of significant functional limitations and a reduced quality of life in patients.
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsSplicing factor 1
go.drugbank.com/bio_entities/BE0009118TargetHumansNecessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor
Synonyms: Zinc finger gene in MEN1 locusRisperidone
go.drugbank.com/drugs/DB00734ApprovedInvestigationalRisperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. … [L12885] Risperidone binds with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug's binding affinity to D2 receptors, and carries lesser activity at several off-targets
Categories: Adrenergic alpha-1 Receptor Antagonists, Serotonin 5-HT1 Receptor AntagonistsInternational brands: Risperidal M-TabCD9 antigen
go.drugbank.com/bio_entities/BE0003377TargetHumansActs as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (PubMed:18541721). Regulates paranodal junction formation (By similarity).
Synonyms: Cell growth-inhibiting gene 2 proteinGlucose-6-phosphate exchanger SLC37A4
go.drugbank.com/bio_entities/BE0011751TargetHumansInorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum (PubMed:10026167, PubMed:21949678). Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic pho...
Synonyms: Transformation-related gene 19 proteinAT-301
go.drugbank.com/drugs/DB16507InvestigationalAT-301 was under investigation in clinical trial NCT01675284 to evaluate the safety, reactogenicity, and humoral immune responses to an inactivated H5N1 influenza vaccine
NXN-188
go.drugbank.com/drugs/DB06096InvestigationalNXN-188 is a first-in-class, dual-action small molecule incorporating both neuronal nitric oxide synthase (nNOS) inhibition and 5-HT agonism that is being developed for the treatment of acute migraine.
Repinotan
go.drugbank.com/drugs/DB06506InvestigationalRepinotan is a high-affinity, selective, full agonist of the 5HT1A-receptor subtype with neuroprotective properties.
Categories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT1A Receptor Antagonists