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Brasofensine

Brasofensine is an orally administered dopamine reuptake inhibitor being developed for the treatment of Parkinson's Disease. Phase I/II trials for brasofensine have been completed in the U.K. … In November 2001, NeuroSearch confirmed that the drug's development was discontinued in favor of NS 2230.

Rolicyclidine

Because of its pharmacodynamic similarity to the drug phencyclidine (PCP), rolicyclidine was added to the Schedule I list of illegal drugs in the USA in the 1970s.

Ezogabine

FDA approved in June 10, 2011 under the name of ezogabine. … Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine.

Cyclacillin

A cyclohexylamido analog of penicillanic acid.

Lonoctocog alfa

Faropenem medoxomil

The prodrug form of faropenem offers dramatically improved oral bioavailability and leads to higher systemic concentrations of the drug. … Faropenem medoxomil is an ester prodrug derivative of the beta-lactam antibiotic [faropenem].

Rivanicline

Rivanicline (TC-2403, RJR-2403, (E)-metanicotine) is a partial agonist at neuronal nicotinic acetylcholine receptors, binding primarily to the α4β2 subtype. … It was originally developed as a potential treatment for Alzheimer's disease for its nootropic effects but has also been found to inhibit the production of Interleukin-8.

ADH-1

Cadherins are cell adhesion and cell signaling molecules crucial to the development of tissues, organs and organisms. … Agents that target and inhibit cadherin function have the potential to attack the progression of cancer at two distinct points: * Direct targeting of cadherins expressed on cancer cells may disturb

Lufotrelvir

Once administered through intravenous infusion, the compound is cleaved into PF-00835231 to exert its anti-viral effects[L31718]. … PF-07304814 is a small molecule prodrug that targets the 3CL^pro protease (M^pro), which is used by viruses like SARS-CoV-2 to assemble and multiply[L31718].

Dimethyltryptamine

An N-methylated indoleamine derivative, a serotonergic hallucinogen found in several plants, especially Prestonia amazonica (Apocynaceae) and in mammalian brain, blood, and urine. It apparently acts as an agonist at some types of seroton...