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Potassium gluconate
go.drugbank.com/drugs/DB13620ApprovedPotassium gluconate is a salt of [DB01345] and is classified as a food additive by the FDA [L2654]. It is also used as a potassium supplement [L2657]. Potassium is an essential nutrient. … It is the most abundant cation in the intracellular fluid, where it plays a key role in maintaining cell function [A32222].
Mixtures: Potassium Plus Vit B ComplexSynonyms: potassium D-gluconatePicoplatin
go.drugbank.com/drugs/DB04874InvestigationalIt causes apoptosis (cell death) by binding to DNA and interfering with DNA replication and transcription. … Picoplatin is a cytotoxic platinum compound in clinical development for the treatment of patients with solid tumors.
Cobicistat
go.drugbank.com/drugs/DB09065ApprovedInvestigationalAlthough it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic exposure of coadministered … Increasing systemic exposure of anti-retrovirals (ARVs) without increasing dosage allows for better treatment outcomes and a decreased side effect profile.
Denufosol
go.drugbank.com/drugs/DB04983InvestigationalA new drug application (NDA) was filed with the FDA in 2011, however, the second phase III clinical trial showed a lack of improvement in lung function for cystic fibrosis patients taking denufosol. … Denufosol has not gained FDA approval, and clinical trials with this drug have ceased since 2011.
Enflurane
go.drugbank.com/drugs/DB00228ApprovedVet approvedWithdrawnEnflurane is a halogenated inhalational anesthetic initially approved by the FDA in 1972. Since this date, it has been withdrawn from the US market. … In addition, it is known to cause increased cardio depressant effects when compared to other inhaled anesthetics.[A202022]
Nitrofural
go.drugbank.com/drugs/DB00336ApprovedVet approvedWithdrawnExcept for topical drug products formulated for dermatologic application, the FDA withdrew its approval for the use of drug products containing nitrofurazone.[L43942] … Nitrofural or nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections.
Minocycline
go.drugbank.com/drugs/DB01017ApprovedInvestigational[A190723] Minocycline was granted FDA approval on 30 June 1971.[L11695] … [A190723] Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines.
Products: MINOCYCLIN 1A PHARMA 50MG, AA-Minocycline 50mg CapsuleDesflurane
go.drugbank.com/drugs/DB01189ApprovedInvestigationalIt was developed in the late 1980s out of a need for a more rapidly acting and rapidly cleared inhaled anesthetic.[A226883,A226888] Desflurane was granted FDA approval on 18 September 1992.[L30285] … Desflurane, or I-653, a a volatile anesthetic that is more rapidly cleared and less metabolized than previous inhaled anesthetics such as [methoxyflurane], [sevoflurane], [enflurane], or [isoflurane].
Flecainide
go.drugbank.com/drugs/DB01195ApprovedInvestigationalWithdrawnFlecainide is a Class I anti-arrhythmic agent like [encainide] and [propafenone]. … [L8878,L5056] Flecainide was granted FDA approval on 31 October 1985.[L8875]
Categories: MATE 1 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: FLECAINID 1A PHARMA 50MG, FLECAINID 1A PHARMA 100MGAcrivastine
go.drugbank.com/drugs/DB09488ApprovedAcrivastine is currently available in combination with pseudoephedrine as the FDA-approved product Semprex-D. … Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever.
Mixtures: Semprex-D, Semprex D