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Peroxisome proliferator-activated receptors
go.drugbank.com/bio_entities/BE0010120TargetHumans and other mammalsMay be required for the propagation of clock information to metabolic pathways regulated by PER2 … Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids.
Polypeptides: Peroxisome proliferator-activated receptor alpha, Peroxisome proliferator-activated receptor deltaSynonyms: Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 1Ioversol
go.drugbank.com/drugs/DB09134ApprovedInvestigationalhydrophilic agent considered to be generally safe[L41790]; however, serious adverse reactions have been reported due to the inadvertent intrathecal administration of ioversol, which is only indicated for … [L41780] Ioversol was approved by the FDA in 1989 and is currently indicated for computed tomographic (CT) imaging and contrast enhancement in peripheral arteriography, coronary arteriography, and left
COVID-19 convalescent plasma
go.drugbank.com/drugs/DB15692Investigational), and use for single patients through an emergency IND (eIND; 21 CFR 312.310). … [L14333] This investigational COVID-19 treatment is currently available through three main pathways: use in registered clinical trials, use through the expanded access COVID-19 protocol (21 CFR 312.305
Categories: Experimental Unapproved Treatments for COVID-19DTS-201
go.drugbank.com/drugs/DB06071ExperimentalDTS-201 may be suitable for the treatment of many types of solid tumors, including tumors sensitive to doxorubicin and potentially other tumors which are not currently treated with doxorubicin but which … DTS-201 is a prodrug of doxorubicin, a widely used anti-cancer drug that Diatos intends to develop for the treatment of various solid tumors. It is activated in the tumor environment.
Prostaglandin E2 Receptors
go.drugbank.com/bio_entities/BE0010100TargetHumansMay play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues … May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function
Polypeptides: Prostaglandin E2 receptor EP1 subtype, Prostaglandin E2 receptor EP2 subtypeSynonyms: PGE receptor EP1 subtype, Prostanoid EP1 receptorPerflubutane
go.drugbank.com/drugs/DB12821ApprovedWithdrawnIt is a cardiovascular drug designed to enable ultrasound to compete more effectively with nuclear stress testing; currently the leading procedure for detecting coronary heart disease.
Vopratelimab
go.drugbank.com/drugs/DB15378InvestigationalVopratelimab is under investigation in clinical trial NCT02904226 (JTX-2011 Alone and in Combination With Anti-PD-1 or Anti-CTLA-4 in Subjects With Advanced and/or Refractory Solid Tumors).
Sulfamoxole
go.drugbank.com/drugs/DB08798ExperimentalSulfamoxole is an antibacterial in the sulfonamide class.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseSynonyms: 2-(p-Aminobenzenesulfonamido)-4,5-dimethyloxazole, 2-(p-Aminobenzolsulfonamido)-4,5-dimethyloxazolSorafenib
go.drugbank.com/drugs/DB00398ApprovedInvestigationalSorafenib is a bi-aryl urea and an oral multikinase inhibitor. … [A255852] First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular carcinoma, sorafenib is also indicated to treat renal carcinoma and differentiated thyroid carcinoma
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesMGN-4893
go.drugbank.com/drugs/DB17338ExperimentalMGN-4893 is an inhibitor of microRNA-451. In February 2011, it was granted FDA orphan designation for the treatment of polycythemia vera.[L47356]
Synonyms: MGN 4893