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Displaying results 4141 - 4150 of 10000 in total
  1. Target

    Integrin alpha-M

    go.drugbank.com/bio_entities/BE0010412
    TargetHumans

    It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. … Integrin ITGAM/ITGB2 is also a receptor for ICAM1 ligand ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124).

    Synonyms: Neutrophil adherence receptor, Leukocyte adhesion receptor MO1
  2. Drug

    Lixmabegagene relduparvovec

    go.drugbank.com/drugs/DB16816
    Investigational

    Lixmabegagene relduparvovec, formerly known as LYS-GM101, is a recombinant adeno-associated virus vector serotype rh.10 (AAVrh.10) carrying the human β-galactosidase gene (GBL1).

  3. Drug

    Biapenem

    go.drugbank.com/drugs/DB13028
    Investigational

    Biapenem has been used in trials studying the treatment of various bacterial infections. … It is a carbapenem antibiotic with a methyl group on the 1-beta position, which gives it stability against degradation by dehydropeptidase I.[A275008]

    Categories: Heterocyclic Compounds, 2-Ring
  4. Target

    High affinity cationic amino acid transporter 1

    go.drugbank.com/bio_entities/BE0000212
    TargetTransporterHumans

    High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues

    Synonyms: Ecotropic retrovirus receptor homolog, Ecotropic retroviral leukemia receptor homolog
  5. Drug

    SynOV1.1

    go.drugbank.com/drugs/DB17539
    Investigational

    It is a recombinant oncolytic adenovirus, controlled by synthetic gene circuit, encoding the human immunostimulating factor cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF).

  6. Drug

    Brasofensine

    go.drugbank.com/drugs/DB04857
    Experimental

    Phase I/II trials for brasofensine have been completed in the U.K. In November 2001, NeuroSearch confirmed that the drug's development was discontinued in favor of NS 2230.

  7. Drug

    JSM 6427

    go.drugbank.com/drugs/DB06139
    Investigational

    It has been biologically validated for therapeutic use in the prevention and treatment of wet AMD, the leading cause of blindness in people over the age of 55. … JSM 6427 is the first small molecule alpha5beta1 integrin receptor antagonist of its kind to be developed.

  8. Drug

    Isatin

    go.drugbank.com/drugs/DB02095
    Experimental

    The compound is found in many plants and Schiff bases of Isatin are have been investigated for pharmaceutical applications.

    Categories: Heterocyclic Compounds, 2-Ring
  9. Drug

    Pimagedine

    go.drugbank.com/drugs/DB05383
    Investigational

    Pimagedine has been developed by Synvista Therapeutics, Inc for the treatment of diabetic kidney disease.

  10. Drug

    Peginterferon alfa-2a

    go.drugbank.com/drugs/DB00008
    ApprovedInvestigational

    When combined together, Peginterferon alfa-2a and [DB00811] have been shown to achieve a SVR between 36% for genotype 1 and 59% for genotypes 2-6 after 48 weeks of treatment. … The use of Peginterferon alfa-2a has largely declined since newer interferon-free antiviral therapies have been developed.

    Categories: Interferon Type I, Treatments for Hepatitis CProducts: PEGASYS 135 MCG/0.5 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ŞIRINGA, 1 ADET, PEGASYS 135 MCG/0.5 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ŞIRINGA, 4 ADET