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Displaying results 4161 - 4170 of 10000 in total

Drug
Lortalamine
go.drugbank.com/drugs/DB09187
Experimental
Lortalamine (LM-1404) is a selective norepinephrine reuptake inhibitor developed in the 1980s.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
Drug
Amedalin
go.drugbank.com/drugs/DB09188
Experimental
Amedalin is a selective norepinephrine reuptake inhibitor developed in the 1970s.
Synonyms: 3-methyl-3-(3-(methylamino)propyl)-1-phenyl-2-indolinone
Drug
Ciglitazone
go.drugbank.com/drugs/DB09201
Experimental
Ciglitazone is a potent and selective PPARγ ligand with an EC50 of 3.0 µM. It is also an anti-hyperglycemic agent in the ob/ob murine model in vivo. … Ciglitazone was never used as a medication, but it sparked interest in the effects of thiazolidinediones.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Inhibitors
Drug
AS-8112
go.drugbank.com/drugs/DB09207
Experimental
AS-8112 is a synthetic compound that acts as a selective antagonist at the dopamine receptor subtypes D2 and D3, and the serotonin receptor 5-HT3.
Categories: Heterocyclic Compounds, 1-Ring
Drug
Droxicam
go.drugbank.com/drugs/DB09215
ApprovedWithdrawn
Droxicam is an oxicam non-steroidal anti-inflammatory drug and a prodrug of [DB00554]. … It is used to reduce pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 1-Ring
Drug
Tolfenamic acid
go.drugbank.com/drugs/DB09216
Approved
By the European Medicine Agency, it was granted in 2016 with the status of orphan for the treatment of supranuclear palsy.[L1291] … Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent.
Categories: Cytochrome P-450 Substrates, Non COX-2 selective NSAIDSProducts: TOLFEDINE 4% W/V SOLUTION FOR INJECTION FOR DOGS AND CATS, Tolfine Solution for Injection 4.0% W/V
Drug
Blonanserin
go.drugbank.com/drugs/DB09223
Investigational
It offers improved tolerability as it lacks side effects such as extrapyramidal symptoms, excessive sedation, or hypotension. … As a second-generation (atypical) antipsychotic, it is significantly more efficacious in the treatment of the negative symptoms of schizophrenia compared to first-generation (typical) antipsychotics.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring
Drug
Melperone
go.drugbank.com/drugs/DB09224
Investigational
Melperone has been used for a span of greater than 30 years in the European Union [L1316]. … Recently, it has been studied as a treatment of psychosis related to Parkinson's disease [L1316].
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme Inhibitors
Drug
Cilnidipine
go.drugbank.com/drugs/DB09232
Investigational
This drug is approved in China, Japan, Korea, India, and several countries in the European Union.[A31970] … Cilnidipine is a dihydropyridine calcium antagonist. It was jointly developed by Fuji Viscera Pharmaceutical Company, Japan and Ajinomoto, Japan and approved in 1995.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring
Drug
Efonidipine
go.drugbank.com/drugs/DB09235
Investigational
This drug is also known as NZ-105, and several studies have been done on its pharmacokinetics in animals [L1456]. … Efonidipine is a calcium channel blocker of the _dihydropyridine class_, commercialized by Shionogi & Co. (Japan). Initially, it was marketed in 1995 under the trade name, _Landel_.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring