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Displaying results 4181 - 4190 of 10000 in total
  1. Drug

    Brinzolamide

    go.drugbank.com/drugs/DB01194
    Approved

    [A2049,A2051] Although systemic anti-carbonic anhydrase (CA) therapy has been used for almost 50 years with varying degrees of success, systemic administration results in an increase in incidences of adverse … [A2051] Brinzolamide was approved by the FDA in 1998 as a standalone product and in 2013 as a combination product with brimonidine tartrate.

    Mixtures: BRİTİL-T 10 MG/ML + 5 MG/ML GÖZ DAMLASI, SÜSPANSİYON, 1 ADET, BRIDINE®Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates
  2. Drug

    Undecylenic acid

    go.drugbank.com/drugs/DB11117
    Approved

    Undecylenic acid was first isolated from the products of distillation of castor oil in 1877 via pyrolysis of ricinoleic acid, and has been polymerized for vinyl production [A32281]. … It is used as a precursor in the manufacture of aromatic chemicals, polymers or modified silicones [L1891].

    Mixtures: NEOFUNGINA® POLVO, NEOFUNGINA® POLVOProducts: Hongocura M, Hongocura S
  3. Drug

    Pimavanserin

    go.drugbank.com/drugs/DB05316
    ApprovedInvestigational

    [L48241,A232573] Pimavanserin was also under review as a potential treatment for dementia-related psychosis; however, as of April 2021, FDA approval has not been granted for this indication despite previous … In fact, pimavanserin is the first antipsychotic drug without D<sub>2</sub> blocking activity.

    Categories: Serotonin 5-HT2 Receptor Antagonists, Serotonin Receptor Antagonists
  4. Drug

    Mycophenolate mofetil

    go.drugbank.com/drugs/DB00688
    ApprovedInvestigational

    [A180826] In addition to the above uses, mycophenolate mofetil has also been studied for the treatment of nephritis and other complications of autoimmune diseases. … Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH).

    Synonyms: 2-morpholinoethyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoateCategories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  5. Drug

    Octisalate

    go.drugbank.com/drugs/DB11062
    Approved

    Octyl salicylate appears to have a good safety profile. It covers wavelength in the range 295-315 nm, peak at 307-310 nm. It is an ester of salicylic acid and 2-ethylhexanol. … Octyl salicylate is used to augment the UVB protection in a sunscreen. Salicylates are weak UVB absorbers and they are generally used in combination with other UV filters.

    Synonyms: 2-Ethylhexyl 2-hydroxybenzoate, 2-Ethylhexyl salicylateMixtures: Derma Geek Nourishing Facial Moisturizer with Sunscreen Broad Spectrum SPF 30, City Sunscreen Serum SPF 30 Doctor Ts Super goop
  6. Target

    Hepatocyte nuclear factor 4-gamma

    go.drugbank.com/bio_entities/BE0003179
    TargetHumans

    Transcription factor. Has a lower transcription activation potential than HNF4-alpha

    Synonyms: Nuclear receptor subfamily 2 group A member 2
  7. Drug

    Pirlindole

    go.drugbank.com/drugs/DB09244
    Experimental

    Pirlindole's efficacy and safety have also been shown in the treatment of fibromyalgia. … This drug is classified as a reversible inhibitor of monoamine oxidase A enzyme (also known as a RIMA drug). It was developed and is currently used as an antidepressant in Russia.

    Synonyms: 2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino(3,2,1-jk)carbazoleCategories: Serotonin 5-HT1 Receptor Antagonists, Serotonin 5-HT1A Receptor Antagonists
  8. Drug

    Surotomycin

    go.drugbank.com/drugs/DB12076
    Investigational

    Surotomycin, given orally, has been shown to be highly effective against both initial and relapsing hamster Clostridium difficile-associated diarrhea, with a potency similar to vancomycin. … Surotomycin has been used in trials studying the treatment of Diarrhea and Clostridium Difficile Infection.

  9. Drug

    Venetoclax

    go.drugbank.com/drugs/DB11581
    ApprovedInvestigational

    Previously, this drug was indicated only for patients with 17p gene deletion [F2130]. … Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process [A18565], [A18566].

    Categories: BCL-2 Inhibitor, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: 4-(4-((2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(1H-pyrrolo(2,3-b)pyridin-5-yloxy)benzamide, 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
  10. Drug

    Burosumab

    go.drugbank.com/drugs/DB14012
    ApprovedInvestigational

    Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic … This is the first drug approved to treat adults and children ages 1 year and older with X-linked hypophosphatemia (XLH), which is a rare, inherited form of rickets.

    Products: CRYSVITA ® SOLUCION PARA INYECCIÓN 10MG/ML, CRYSVITA® SOLUCIÓN PARA INYECCIÓN 20 MG/ML