Octisalate

Identification

Brand Names
Eucerin, Meijer, Sumadan Wash
Generic Name
Octisalate
DrugBank Accession Number
DB11062
Background

Also known as Ethylhexyl Salicylate. Octyl salicylate is an oil soluble chemical sunscreen agent that absorbs UVB radiation. It does not protect against UVA. Octyl salicylate is used to augment the UVB protection in a sunscreen. Salicylates are weak UVB absorbers and they are generally used in combination with other UV filters. Octyl salicylate appears to have a good safety profile. It covers wavelength in the range 295-315 nm, peak at 307-310 nm.

It is an ester of salicylic acid and 2-ethylhexanol. The salicylate portion of the molecule absorbs ultraviolet light to protect skin from the harmful effects of exposure to sunlight, while the ethylhexanol portion functions as an emollient.

Type
Small Molecule
Groups
Approved, Investigational
Structure
Thumb
Weight
Average: 250.3334
Monoisotopic: 250.15689457
Chemical Formula
C15H22O3
Synonyms
  • 2-Ethylhexyl 2-hydroxybenzoate
  • 2-Ethylhexyl salicylate
  • Octisalate
  • Octyl salicylate
External IDs
  • USAF DO-11

Pharmacology

Indication

Ingredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer.

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Data not found.

Mechanism of action

Chemical sunscreen, it acts through absorption of UVB light and not UVA.

Absorption

Intended for local use only, no systemic absorption.

Volume of distribution

Intended for local use only, no systemic absorption.

Protein binding

Intended for local use only, no systemic absorption.

Metabolism

Intended for local use only, no systemic absorption.

Route of elimination

Intended for local use only, no systemic absorption.

Half-life

Intended for local use only, no systemic absorption.

Clearance

Intended for local use only, no systemic absorption.

Adverse Effects
Adverseeffects
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Toxicity

LD50, (oral, rat): > 5000 mg/Kg. LD50 (dermal, rabbit): > 5000 mg/Kg.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products2
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Active Moieties
NameKindUNIICASInChI Key
Salicylic acidunknownO414PZ4LPZ69-72-7YGSDEFSMJLZEOE-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
01 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
02 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
02 Cushion Spf45 SunscreenOctisalate (5 g/100mL) + Octinoxate (5 g/100mL) + Octocrylene (2.5 g/100mL) + Titanium dioxide (13.5 g/100mL) + Zinc oxide (8 g/100mL)LiquidTopicalCOIZ CO LTD2019-06-30Not applicableUS flag
03 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
04 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
05 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
06 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
07 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
08 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
09 Balancing Foundation SPF 15Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL)EmulsionTopicalThe Body Shop, Wake Forest2009-09-062017-10-05US flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
4362 First Aid KitOctisalate (5 g/100mL) + Ammonia (0.045 g/0.3mL) + Avobenzone (1 g/100mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Homosalate (5 g/100mL) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Octinoxate (7.5 g/100mL) + Oxybenzone (6 g/100mL) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL)KitOphthalmic; Respiratory (inhalation); TopicalHoneywell Safety Products USA, Inc.2018-09-13Not applicableUS flag
BEYOND THE SHAVE For MenOctisalate (5 g/100mL) + Allantoin (0.5 g/100mL) + Avobenzone (3.0 g/100mL) + Dimethicone (2.9 g/100mL) + Homosalate (2.5 g/100mL) + Octasulfur (3.0 g/100mL) + Octocrylene (2.7 g/100mL)KitTopicalRodan & Fields2017-06-01Not applicableUS flag
by Selected Daily Broad Spectrum SunscreenOctisalate (2.0 g/50mL) + Octinoxate (3.5 g/50mL)CreamTopicalGaram Of Nature2021-07-01Not applicableUS flag
CoreTex Professional Outdoor Skin Protection WalletOctisalate (5 g/100mL) + Octisalate (5 g/100g) + Octisalate (5 g/100mL) + Avobenzone (1 g/100mL) + Avobenzone (1 g/100g) + Avobenzone (3 g/100mL) + Benzocaine (6 g/100mL) + Diphenhydramine hydrochloride (2 g/100mL) + Ethanol (62.5 mL/100mL) + Homosalate (5 g/100mL) + Homosalate (5 g/100g) + Homosalate (7.5 g/100mL) + Octinoxate (7.5 g/100mL) + Octinoxate (7.5 g/100g) + Octocrylene (2.5 g/100mL) + Oxybenzone (6 g/100mL) + Oxybenzone (6 g/100g) + Oxybenzone (6 g/100mL) + Synthetic camphor (0.1 g/100mL) + Zinc acetate dihydrate (1 g/100mL)TopicalCoreTex Products2019-11-27Not applicableUS flag
CoreTex Professional Outdoor Skin Protection WalletOctisalate (5 g/100mL) + Octisalate (5 g/100g) + Octisalate (5 g/100mL) + Avobenzone (1 g/100mL) + Avobenzone (1 g/100g) + Avobenzone (3 g/100mL) + Benzocaine (6 g/100mL) + Diphenhydramine hydrochloride (2 g/100mL) + Ethanol (62.5 mL/100mL) + Homosalate (5 g/100mL) + Homosalate (5 g/100g) + Homosalate (7.5 g/100mL) + Octinoxate (7.5 g/100mL) + Octinoxate (7.5 g/100g) + Octocrylene (2.5 g/100mL) + Oxybenzone (6 g/100mL) + Oxybenzone (6 g/100g) + Oxybenzone (6 g/100mL) + Synthetic camphor (0.1 g/100mL) + Zinc acetate dihydrate (1 g/100mL)TopicalCoreTex Products2019-11-27Not applicableUS flag
CoreTex Professional Outdoor Skin Protection WalletOctisalate (5 g/100mL) + Octisalate (5 g/100g) + Octisalate (5 g/100mL) + Avobenzone (1 g/100mL) + Avobenzone (1 g/100g) + Avobenzone (3 g/100mL) + Benzocaine (6 g/100mL) + Diphenhydramine hydrochloride (2 g/100mL) + Ethanol (62.5 mL/100mL) + Homosalate (5 g/100mL) + Homosalate (5 g/100g) + Homosalate (7.5 g/100mL) + Octinoxate (7.5 g/100mL) + Octinoxate (7.5 g/100g) + Octocrylene (2.5 g/100mL) + Oxybenzone (6 g/100mL) + Oxybenzone (6 g/100g) + Oxybenzone (6 g/100mL) + Synthetic camphor (0.1 g/100mL) + Zinc acetate dihydrate (1 g/100mL)TopicalCoreTex Products2019-11-27Not applicableUS flag
D-one By Tamdoan Bb LightOctisalate (5 g/100g) + Adenosine (0.04 g/100g) + Arbutin (2 g/100g) + Diethylamino hydroxybenzoyl hexyl benzoate (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (1 g/100g) + Titanium dioxide (2.54 g/100g) + Zinc oxide (5.99 g/100g)CreamTopicalDran Co.,ltd2016-02-232016-09-05US flag
D-one By Tamdoan Bb MediumOctisalate (5 g/100g) + Adenosine (0.04 g/100g) + Arbutin (2 g/100g) + Diethylamino hydroxybenzoyl hexyl benzoate (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (1 g/100g) + Titanium dioxide (2.54 g/100g) + Zinc oxide (5.99 g/100g)CreamTopicalDran Co.,ltd2019-11-19Not applicableUS flag
D-one By Tamdoan Sunscreen 50Octisalate (5 g/100g) + Adenosine (0.04 g/100g) + Arbutin (2 g/100g) + Diethylamino hydroxybenzoyl hexyl benzoate (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (1 g/100g) + Titanium dioxide (2.54 g/100g) + Zinc oxide (5.99 g/100g)CreamTopicalDran Co.,ltd2019-11-19Not applicableUS flag
Dr.althea Aurora Cover Cushion 21Octisalate (4.8 g/100g) + Adenosine (0.04 g/100g) + Nicotinamide (2 g/100g) + Octinoxate (7 g/100g) + Octocrylene (2 g/100g) + Titanium dioxide (9.00552 g/100g) + Zinc oxide (2 g/100g)LiquidTopicalDr. Althea2017-04-032018-11-22US flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
4X49Y0596W
CAS number
118-60-5
InChI Key
FMRHJJZUHUTGKE-UHFFFAOYSA-N
InChI
InChI=1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3
IUPAC Name
2-ethylhexyl 2-hydroxybenzoate
SMILES
CCCCC(CC)COC(=O)C1=C(O)C=CC=C1

References

General References
  1. product info [Link]
  2. MSDS [Link]
Human Metabolome Database
HMDB0061839
PubChem Substance
347911101
ChemSpider
8061
RxNav
91327
ChEBI
88639
ChEMBL
CHEMBL1329203
Wikipedia
Octyl_salicylate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedSupportive CareAtrophic Vaginitis / Endometrial Hyperplasia / Pelvic Organ Prolapse (POP)1
4CompletedSupportive CareSkin Irritation1
4CompletedTreatmentAcne Prone Skin1
4CompletedTreatmentActinic Keratosis (AK)1
4CompletedTreatmentBMI >27 kg/m2 / Cardiovascular Disease (CVD)1
4CompletedTreatmentChronic Hand Eczema1
4CompletedTreatmentPostoperative pain1
4TerminatedNot AvailableSkin Aging1
4TerminatedTreatmentSmall for Gestational Age (Disorder)1
3CompletedTreatmentDermatitis, Dermatitis Atopic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
KitOphthalmic; Respiratory (inhalation); Topical
GelCutaneous
PowderTopical
SalveTopical
Liquid; sprayTopical
OilTopical
OintmentTopical
KitOral; Topical
Cloth; creamTopical
CreamTopical
JellyTopical
CreamCutaneous
LipstickTopical
Gel; kit; lotionTopical
Liquid; lotionTopical
Kit; stickTopical
SpongeTopical
Cream, augmentedTopical
Lotion / shampooTopical
PasteTopical
LiquidTopical
SolutionTopical
StickTopical
EmulsionTopical
Kit; lotionTopical
LotionCutaneous
Cream; kitTopical
Jelly; kitTopical
AerosolTopical
Spray, suspensionTopical
SprayOral
KitTopical
SprayTopical
SuspensionTopical
LotionOral
ClothTopical
Lotion; sprayTopical
LotionTopical
GelTopical
Aerosol, foamTopical
Aerosol, sprayTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0238 mg/mLALOGPS
logP4.79ALOGPS
logP5.35ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)9.72ChemAxon
pKa (Strongest Basic)-4.3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area46.53 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity72.21 m3·mol-1ChemAxon
Polarizability28.8 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
GC-MS Spectrum - EI-BGC-MSsplash10-00di-9800000000-e6bf91bd63e14169eb92
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created on December 03, 2015 16:51 / Updated on February 21, 2021 18:52