Explore a selection of our essential drug information below, or:
Identification
- Brand Names
- Eucerin, Meijer, Sumadan Wash
- Generic Name
- Octisalate
- DrugBank Accession Number
- DB11062
- Background
Also known as Ethylhexyl Salicylate. Octyl salicylate is an oil soluble chemical sunscreen agent that absorbs UVB radiation. It does not protect against UVA. Octyl salicylate is used to augment the UVB protection in a sunscreen. Salicylates are weak UVB absorbers and they are generally used in combination with other UV filters. Octyl salicylate appears to have a good safety profile. It covers wavelength in the range 295-315 nm, peak at 307-310 nm.
It is an ester of salicylic acid and 2-ethylhexanol. The salicylate portion of the molecule absorbs ultraviolet light to protect skin from the harmful effects of exposure to sunlight, while the ethylhexanol portion functions as an emollient.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Octisalate (DB11062)
- Weight
- Average: 250.3334
Monoisotopic: 250.15689457 - Chemical Formula
- C15H22O3
- Synonyms
- 2-Ethylhexyl 2-hydroxybenzoate
- 2-Ethylhexyl salicylate
- Octisalate
- Octyl salicylate
- External IDs
- USAF DO-11
Pharmacology
- Indication
Ingredient in sunscreens for protection against damage effects of sun light, provides protection from sunburns, aging and skin cancer.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination for prophylaxis of Sunburn ••• ••• - Contraindications & Blackbox Warnings
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Data not found.
- Mechanism of action
Chemical sunscreen, it acts through absorption of UVB light and not UVA.
- Absorption
Intended for local use only, no systemic absorption.
- Volume of distribution
Intended for local use only, no systemic absorption.
- Protein binding
Intended for local use only, no systemic absorption.
- Metabolism
Intended for local use only, no systemic absorption.
- Route of elimination
Intended for local use only, no systemic absorption.
- Half-life
Intended for local use only, no systemic absorption.
- Clearance
Intended for local use only, no systemic absorption.
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
LD50, (oral, rat): > 5000 mg/Kg. LD50 (dermal, rabbit): > 5000 mg/Kg.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Active Moieties
Name Kind UNII CAS InChI Key Salicylic acid unknown O414PZ4LPZ 69-72-7 YGSDEFSMJLZEOE-UHFFFAOYSA-N - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image (Re)Setting Refreshing Mist SPF 40 Octisalate (4.9 g/100mL) + Avobenzone (2.9 g/100mL) + Homosalate (9.8 g/100mL) + Octocrylene (9.5 g/100mL) Spray Topical Supergoop, LLC 2022-01-05 Not applicable US 
01 Balancing Foundation SPF 15 Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 US 02 Balancing Foundation SPF 15 Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 US 02 Cushion Spf45 Sunscreen Octisalate (5 g/100mL) + Octinoxate (5 g/100mL) + Octocrylene (2.5 g/100mL) + Titanium dioxide (13.5 g/100mL) + Zinc oxide (8 g/100mL) Liquid Topical COIZ CO LTD 2019-06-30 Not applicable US 03 Balancing Foundation SPF 15 Octisalate (2.5 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Titanium dioxide (1.45 mg/0.5mL) Emulsion Topical The Body Shop, Wake Forest 2009-09-06 2017-10-05 US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 4362 First Aid Kit Octisalate (5 g/100mL) + Ammonia (0.045 g/0.3mL) + Avobenzone (1 g/100mL) + Bacitracin zinc (400 [iU]/1g) + Benzalkonium chloride (1.3 mg/1mL) + Ethanol (0.5 mL/1mL) + Homosalate (5 g/100mL) + Hydrocortisone acetate (1 g/100g) + Isopropyl alcohol (0.7 mL/1mL) + Lidocaine hydrochloride (20 mg/1mL) + Neomycin sulfate (3.5 mg/1g) + Octinoxate (7.5 g/100mL) + Oxybenzone (6 g/100mL) + Polymyxin B sulfate (5000 [iU]/1g) + Povidone-iodine (10 mg/1mL) + Water (98.6 mL/100mL) Kit Ophthalmic; Respiratory (inhalation); Topical Honeywell Safety Products USA, Inc 2018-09-13 Not applicable US BEYOND THE SHAVE For Men Octisalate (5 g/100mL) + Allantoin (0.5 g/100mL) + Avobenzone (3.0 g/100mL) + Dimethicone (2.9 g/100mL) + Homosalate (2.5 g/100mL) + Octasulfur (3.0 g/100mL) + Octocrylene (2.7 g/100mL) Kit Topical Rodan & Fields 2017-06-01 Not applicable US by Selected Daily Broad Spectrum Sunscreen Octisalate (2.0 g/50mL) + Octinoxate (3.5 g/50mL) Cream Topical Garam Of Nature 2021-07-01 Not applicable US CoreTex Professional Outdoor Skin Protection Wallet Octisalate (5 g/100mL) + Octisalate (5 g/100g) + Octisalate (5 g/100mL) + Avobenzone (1 g/100mL) + Avobenzone (1 g/100g) + Avobenzone (3 g/100mL) + Benzocaine (6 g/100mL) + Diphenhydramine hydrochloride (2 g/100mL) + Ethanol (62.5 mL/100mL) + Homosalate (5 g/100mL) + Homosalate (5 g/100g) + Homosalate (7.5 g/100mL) + Octinoxate (7.5 g/100mL) + Octinoxate (7.5 g/100g) + Octocrylene (2.5 g/100mL) + Oxybenzone (6 g/100mL) + Oxybenzone (6 g/100g) + Oxybenzone (6 g/100mL) + Synthetic camphor (0.1 g/100mL) + Zinc acetate dihydrate (1 g/100mL) Gel; Kit; Lipstick; Liquid; Lotion; Swab Topical CoreTex Products Inc 2019-11-27 Not applicable US CoreTex Professional Outdoor Skin Protection Wallet Octisalate (5 g/100mL) + Octisalate (5 g/100g) + Octisalate (5 g/100mL) + Avobenzone (1 g/100mL) + Avobenzone (1 g/100g) + Avobenzone (3 g/100mL) + Benzocaine (6 g/100mL) + Diphenhydramine hydrochloride (2 g/100mL) + Ethanol (62.5 mL/100mL) + Homosalate (5 g/100mL) + Homosalate (5 g/100g) + Homosalate (7.5 g/100mL) + Octinoxate (7.5 g/100mL) + Octinoxate (7.5 g/100g) + Octocrylene (2.5 g/100mL) + Oxybenzone (6 g/100mL) + Oxybenzone (6 g/100g) + Oxybenzone (6 g/100mL) + Synthetic camphor (0.1 g/100mL) + Zinc acetate dihydrate (1 g/100mL) Gel; Kit; Lipstick; Liquid; Lotion; Swab Topical CoreTex Products Inc 2019-11-27 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- 4X49Y0596W
- CAS number
- 118-60-5
- InChI Key
- FMRHJJZUHUTGKE-UHFFFAOYSA-N
- InChI
- InChI=1S/C15H22O3/c1-3-5-8-12(4-2)11-18-15(17)13-9-6-7-10-14(13)16/h6-7,9-10,12,16H,3-5,8,11H2,1-2H3
- IUPAC Name
- 2-ethylhexyl 2-hydroxybenzoate
- SMILES
- CCCCC(CC)COC(=O)C1=C(O)C=CC=C1
References
- General References
- External Links
- Human Metabolome Database
- HMDB0061839
- PubChem Substance
- 347911101
- ChemSpider
- 8061
- 91327
- ChEBI
- 88639
- ChEMBL
- CHEMBL1329203
- Wikipedia
- Octyl_salicylate
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Active Not Recruiting Treatment Photodamaged Skin / Volume Deficiency of the Midface 1 somestatus stop reason just information to hide Not Available Completed Not Available Acne, Adult 1 somestatus stop reason just information to hide Not Available Completed Not Available Arousal Disorders, Sexual / Dyspareunia (Female Excluding Psychogenic) / Hypoactive Sexual Desire Disorder (HSDD) / Hypoestrogenism / Menopause related conditions / Vulvovaginal Disease 1 somestatus stop reason just information to hide Not Available Completed Not Available Fatty Liver, Non-alcoholic Fatty Liver Disease, NAFLD 1 somestatus stop reason just information to hide Not Available Completed Basic Science Microbiota 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Kit Ophthalmic; Respiratory (inhalation); Topical Gel Cutaneous Powder Topical Salve Topical Liquid; spray Topical Oil Topical Spray Cutaneous Ointment Topical Cream; kit; oil; stick Topical Kit Oral; Topical Kit; ointment; stick Topical Cloth; cream Topical Cream Topical Jelly Topical Cream Cutaneous Lipstick Topical Gel; kit; lotion Topical Gel; kit; lipstick; liquid; lotion; swab Topical Cream; gel; kit; lotion Topical Kit; stick Topical Stick Cutaneous Liquid; lotion Topical Sponge Topical Kit; lipstick Topical Cream, augmented Topical Lotion / shampoo Topical Paste Topical Liquid Topical Solution Topical Cream; kit Topical Stick Topical Cream; kit; lotion Topical Emulsion Topical Kit; lotion Topical Cream; kit; liquid; lotion Topical Kit; spray Topical Lotion Cutaneous Jelly; kit Topical Aerosol, spray Cutaneous Aerosol Topical Spray, suspension Topical Spray Oral Kit Topical Spray Topical Suspension Topical Kit; lotion; stick Topical Lotion Oral Cloth Topical Kit; liquid Topical Lotion; spray Topical Lotion Topical Gel; kit Topical Gel Topical Aerosol, foam Topical Aerosol, spray Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0238 mg/mL ALOGPS logP 4.79 ALOGPS logP 5.35 Chemaxon logS -4 ALOGPS pKa (Strongest Acidic) 9.72 Chemaxon pKa (Strongest Basic) -4.3 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 46.53 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 72.21 m3·mol-1 Chemaxon Polarizability 28.8 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 167.3550048 predictedDarkChem Lite v0.1.0 [M-H]- 160.12541 predictedDeepCCS 1.0 (2019) [M+H]+ 167.1543048 predictedDarkChem Lite v0.1.0 [M+H]+ 162.48341 predictedDeepCCS 1.0 (2019) [M+Na]+ 167.1345048 predictedDarkChem Lite v0.1.0 [M+Na]+ 170.01018 predictedDeepCCS 1.0 (2019)
Drug created at December 03, 2015 16:51 / Updated at February 21, 2021 18:52