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Trastuzumab
go.drugbank.com/drugs/DB00072ApprovedInvestigationalIt is suggested that the overexpression or gene amplification of HER2 has been found in about 20–30% of breast cancers and elevated activation of HER2 triggers multiple downstream pathways leading to abnormal … Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody [A40276] that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular
Mixtures: PHESGO® 1200 MG/600 MG, PHESGO® 1200 MG/600 MGProducts: OGIVRI 150 MG, HERZUMA 150 MGGliclazide
go.drugbank.com/drugs/DB01120ApprovedInvestigationalGliclazide is extensively metabolized by the liver; its metabolites are excreted in both urine (60-70%) and feces (10-20%). … Gliclazide has been shown to decrease fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels (reflective of the last 8-10 weeks of glucose control).
Mixtures: GLIFOR PLUS 30 MG/1000 MG DEĞIŞTIRILMIŞ SALIMLI TABLET, 30 ADET, GLIFOR PLUS 30 MG/1000 MG DEĞIŞTIRILMIŞ SALIMLI TABLET, 60 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesRivaroxaban
go.drugbank.com/drugs/DB06228ApprovedInvestigationalOnly the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. FDA approved on July 1, 2011.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: XARELTO 10 MG FILM KAPLI TABLET, 100 ADET, VOXABAN 10 MG FİLM KAPLI TABLET, 100 ADETMethoxsalen
go.drugbank.com/drugs/DB00553ApprovedInvestigationalA naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2A6 InhibitorsSynonyms: 8-MP, 8-methoxy-4',5':6,7-furocoumarinCetuximab
go.drugbank.com/drugs/DB00002ApprovedInvestigational[A228083] EGFR has been implicated in various types of cancer, as it is often overexpressed in malignant cells [A227973] and EGFR overexpression has been linked to more advanced disease and poor prognosis … [A227963] EGFR is often mutated in certain types of cancer and serves as a driver of tumorigenesis.
Products: ERBITUX 500 MG/100 ML IV INFUZYON ICIN COZELTI ICEREN FLAKON, 1 ADET, ERBITUX 100 MG/20 ML IV INFUZYON ICIN COZELTI ICEREN FLAKON, 1 ADETMebeverine
go.drugbank.com/drugs/DB12554ApprovedInvestigationalWithdrawnMebeverine has been investigated for the treatment of Irritable Bowel Syndrome and Post-cholecystectomy Gastrointestinal Spasms.
Products: DUSPATALIN 100 MG KAPLI TABLET, 50 ADET, DUSPATALIN LIKIT 10 MG/ML, 250 MLHydralazine
go.drugbank.com/drugs/DB01275ApprovedInvestigationalOriginally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed. … [A186841] Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and only as adjunct therapy in the treatment of heart failure.
Mixtures: TRI NORMIN 50Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsSuccinylcholine
go.drugbank.com/drugs/DB00202ApprovedInvestigational[A19054] It has been widely used for over 50 years,[A299] most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and surgical procedures. … Its rapid onset and offset, with effects beginning within 60 seconds of intravenous administration and lasting between four to six minutes, make succinylcholine particularly useful in the setting of short
Synonyms: 2,2'-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)Products: QUELICIN 1000 MG/10 ML, ETHICHOLINE INJECTION 100 mg/2 mlPiracetam
go.drugbank.com/drugs/DB09210ApprovedWithdrawnIt shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of the neurotransmitter γ-aminobutyric acid (GABA). … Piracetam has neuroprotective and anticonvulsant properties and is reported to improve neural plasticity [A31532].
Products: CEREBROFIL 800 MG FİLM TABLET, 50 ADET, NOTROSERB 1 G IM/IV ENJEKSİYONLUK ÇÖZELTİ , 100 ADETMetoclopramide
go.drugbank.com/drugs/DB01233ApprovedInvestigational[T683] Metoclopramide was initially approved by the FDA in 1980.[A184922] … Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system.
Mixtures: PCP 100 Kit, ESPAVEN MDCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates