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Displaying results 411 - 420 of 10000 in total
  1. Drug

    Echinomycin

    go.drugbank.com/drugs/DB15582
    Experimental

    Echinomycin is a cytotoxic polypeptide quinoxaline antibiotic isolated from _Streptomyces echinatus_ that binds to DNA and inhibits RNA synthesis.

    Categories: Heterocyclic Compounds, 2-RingSynonyms: Quinomycin A
  2. Drug

    Silibinin

    go.drugbank.com/drugs/DB09298
    Investigational

    Silibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in an approximately equimolar ratio. … Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin

    Categories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-RingSynonyms: Silibinin A, Silybin A
  3. Drug

    Tividenofusp alfa

    go.drugbank.com/drugs/DB17628
    ApprovedInvestigational

    Hunter syndrome is a rare, X-linked lysosomal storage disorder caused by a deficiency in the enzyme iduronate-2-sulfatase (IDS), which leads to the toxic accumulation of glycosaminoglycans (GAGs) throughout … Tividenofusp alfa is a recombinant human IDS fused to a monoclonal antibody that targets the human insulin receptor (HIR), utilizing receptor-mediated transcytosis to gain access to the central nervous

    Synonyms: 676>S, L 678>A, Y, - L-iduronate sulfate sulfatase, EC:3.1.6.13) pro-protein (1-525), fused via the peptide linker 526 GGGGS 530 to a human immunoglobulin G1 C-terminal Fc fragment (531-757) variant (L 544>A, L 545>A, T
  4. Drug

    Stallimycin

    go.drugbank.com/drugs/DB20261
    Experimental

    Stallimycin has a monoisotopic molecular weight of 481.22 Da. … Stallimycin is a small molecule drug. The usage of the INN stem '-mycin' in the name indicates that Stallimycin is a antibiotic, produced by Streptomyces strain.

    Synonyms: Distamycin a
  5. Drug

    Basifungin

    go.drugbank.com/drugs/DB14058
    Experimental

    Basifungin, also known as _aureuobacidin A_, is a phosphorylceramide synthase inhibitor [L2960], [A33381].

    Synonyms: Aureobasidin A
  6. Drug

    Streptolydigin

    go.drugbank.com/drugs/DB04785
    Experimental

    Streptolydigin is an antibiotic isolated from culture filtrates of Streptomyces lydicus. It is active against gram-postive bacteria except micrococci.

    Synonyms: Afragilimycin A
  7. Drug

    Hexanoyl-CoA

    go.drugbank.com/drugs/DB02563
    Experimental

    Synonyms: n-hexanoyl-coenzyme A, S-Hexanoyl-coenzym-ACategories: Thioesters of coenzyme A, Heterocyclic Compounds, 2-Ring
  8. Drug

    Acetoacetyl-CoA

    go.drugbank.com/drugs/DB03059
    Experimental

    Synonyms: S-Acetoacetyl-coenzym A, S-acetoacetyl-coenzyme ACategories: Thioesters of coenzyme A, Heterocyclic Compounds, 2-Ring
  9. Drug

    Loncastuximab tesirine

    go.drugbank.com/drugs/DB16222
    ApprovedInvestigational

    Relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL) are a therapeutic challenge for patients who have undergone prior systemic therapies with limited success. … [L45206] This therapy was developed by ADC Therapeutics and its accelerated approval for relapsed or refractory B-cell lymphoma is based on promising results from the LOTIS-2 clinical trial.

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: Humanized monoclonal immunoglobulin G1 antibody directed against human CD19 conjugated to SG3199 through A protease cleavable valine-alanine linker
  10. Drug

    Lixadesiran

    go.drugbank.com/drugs/DB17295
    Experimental

    Synonyms: Rna, (a-c-a-u-c-a-u-c-a-g-a-c-c-a-g-g-c-a-c-c-a-g-a-c-c), complex with rna (g-g-u-c-u-g-g-u-g-c-c-u-g-g-u-c-u-g-a-u-g-a-u-g-u) (1:1)