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Mitiglinide
go.drugbank.com/drugs/DB01252InvestigationalMitiglinide is a drug for the treatment of type 2 diabetes. It may stimulate insulin secretion in beta-cells by closing off ATP dependant potassium ion channels.
Categories: Heterocyclic Compounds, 2-RingRheinanthrone
go.drugbank.com/drugs/DB13175ExperimentalRheinanthrone is the active metabolite of senna glycoside [DB11365] known for its laxative effect [A19235]. It is commonly produced by plants of the Rheum species [L772].
Palifosfamide
go.drugbank.com/drugs/DB05668InvestigationalPalifosfamide (ZIO-201) is a proprietary stabilized metabolite of ifosfamide. Ifosfamide has been shown to be effective in high doses in treating testicular cancer, sarcoma and lymphoma.
Categories: Heterocyclic Compounds, 1-RingXL784
go.drugbank.com/drugs/DB04991InvestigationalXL784 is a potent inhibitor of the ADAM-10 metalloprotease enzyme, a target of significant interest because of its important role in blood vessel formation and cell proliferation. … Results of single dose Phase I clinical trials of XL784 administered orally to 96 healthy volunteers have demonstrated that XL784 has attractive safety and pharmacokinetic profiles.
Dapoxetine
go.drugbank.com/drugs/DB04884InvestigationalDapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. … In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo.
Mixtures: TADA PLUS 30/20 MG FILM KAPLI TABLET ,4 ADET, TADA PLUS 30/20 MG FILM KAPLI TABLET ,8 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsMotexafin lutetium
go.drugbank.com/drugs/DB05296InvestigationalMotexafin lutetium is a pentadentate aromatic metallotexaphyrin with photosensitizing properties. … Motexafin lutetium (MLu) is a second-generation photosensitizer for photodynamic therapy (PDT) of cancer. It belongs to the family of drugs called metallotexaphyrins. Also called lutetium texaphyrin.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds with 4 or More RingsHGS-TR2J
go.drugbank.com/drugs/DB05895ExperimentalIt is developed by Human Genome Sciences, Inc and is under Phase I of clinical trial. … HGS-TR2J is a novel agonistic human monoclonal antibody to TRAIL Receptor 2, in patients with advanced solid malignancies.
Chlorpropamide
go.drugbank.com/drugs/DB00672ApprovedWithdrawnSulfonylureas are associated with weight gain, though less so than insulin. … It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesSynonyms: 1-(p-chlorobenzenesulfonyl)-3-propylurea, 1-(p-chlorophenylsulfonyl)-3-propylureaOmega-6 fatty acids
go.drugbank.com/drugs/DB13168InvestigationalNutraceuticalArachidonic acid, which is a main precursor of eicosanoids, is an example of omega-6 (n-6) polyunsaturated fatty acids. Vegetable oil is a major dietary sources of omega-6 fatty acids. … Omega-6 fatty acids are polyunsaturated fatty acids with a final carbon-carbon double bond in the n-6 position, that is, the sixth bond, counting from the methyl end.
Synonyms: n-6 fatty acids, ω-6 fatty acidsArachidonic Acid
go.drugbank.com/drugs/DB04557ApprovedInvestigationalWithdrawnIt is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. … It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. [PubChem]
Mixtures: SIMILAC ALIMENTUM 400 G TOZCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 Substrates