Chlorpropamide is a sulfonylurea used in the treatment of non insulin dependent diabetes mellitus. It belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin.
- Mechanism
- Curator reviewed
Sulfonylureas such as chlorpropamide bind to ATP-sensitive potassium channels on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.
- Primary indication
- For treatment of NIDDM in conjunction with diet and exercise.Curator reviewed · 2 structured indications
- Formula / weight
- C10H13ClN2O3S · 276.74 g/mol (avg)
- First approval
- Canada, 1958 · United States, 1958
- Code names
- Hoechst 18810 · P 607 · U 9818
Resolves to
RKWGIWYCVPQPMF-UHFFFAOYSA-NSMILESCCCNC(=O)NS(=O)(=O)C1=CC=C(Cl)C=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Chlorpropamide, and which of those have an active Phase 3 trial?
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