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Neutral amino acid transporter B(0)
go.drugbank.com/bio_entities/BE0000236TargetTransporterHumansMediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons.
Synonyms: Baboon M7 virus receptor, RD114/simian type D retrovirus receptorRenzapride
go.drugbank.com/drugs/DB04917InvestigationalRenzapride is currently in Phase III clinical development in the United States for the treatment of constipation-predominant irritable bowel syndrome (IBS-C). … It has been suggested that renzapride is effective in the treatment of irritable bowel syndrome with alternating stool pattern. It is being developed by Alizyme of the UK.
Categories: Serotonin 5-HT4 Receptor Agonists, Serotonin Receptor AgonistsDeoxyhypusine hydroxylase
go.drugbank.com/bio_entities/BE0018877TargetHumansCatalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-tran...
Synonyms: HEAT-like repeat-containing protein 1CD320 antigen
go.drugbank.com/bio_entities/BE0019797TransporterHumansReceptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213).
Synonyms: Transcobalamin receptorVolume-regulated anion channel subunit LRRC8A
go.drugbank.com/bio_entities/BE0016599TargetHumansEssential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubM...
Synonyms: Leucine-rich repeat-containing protein 8APW2101
go.drugbank.com/drugs/DB06483ExperimentalThe development of PW2101 has since been discontinued. … PW2101 is a beta blocker intended for the treatment of hypertension and angina.
PG-530742
go.drugbank.com/drugs/DB05495InvestigationalPG-530742 selectively inhibits certain matrix metalloproteinases that have been implicated in the cartilage degradation that occurs in osteoarthritis.
Bevantolol
go.drugbank.com/drugs/DB01295InvestigationalBevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension. … Mechanism of Action Animal experiments confirm both agonist and antagonist effects on alpha-receptors, in addition to antagonist activity at beta-1 receptors.
Synonyms: 1-((2-(3,4-dimethoxyphenyl)ethyl)amino)-3-(3-methylphenoxy)-2-propanol, 1-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-3-m-tolyloxy-propan-2-olCategories: Adrenergic alpha-1 Receptor Antagonists, Adrenergic beta-1 Receptor AntagonistsSteroidogenic factor 1
go.drugbank.com/bio_entities/BE0003359TargetHumansActivated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation … Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692
Synonyms: Steroid hormone receptor Ad4BP, Nuclear receptor subfamily 5 group A member 1Janus (JAK) kinases
go.drugbank.com/bio_entities/BE0027976TargetHumansPhosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. … Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription.
Polypeptides: Non-receptor tyrosine-protein kinase TYK2Function: acetylcholine receptor binding