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Zonisamide
go.drugbank.com/drugs/DB00909ApprovedInvestigationalZonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures. … The US and Europe approved it in 2000 and 2005, respectively.[A1379,A1383]
Synonyms: Benzo[d]isoxazol-3-yl-methanesulfonamide, 1,2-Benzisoxazole-3-methanesulfonamideCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesTinidazole
go.drugbank.com/drugs/DB00911ApprovedInvestigationalA nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections.
Synonyms: 1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitroimidazoleMixtures: GYNOMAX L VAJINAL OVUL, 7 ADET, GYNOMAX 100 MG/150 MG VAJINAL OVUL, 7 ADETRepaglinide
go.drugbank.com/drugs/DB00912ApprovedInvestigationalApproximately one month of therapy is required before a decrease in fasting blood glucose is seen. Meglitnides may have a neutral effect on weight or cause a slight increase in weight. … Approximately 90% of a single orally administered dose is eliminated in feces and 8% in urine.
Mixtures: REPAMEF 1/1000 MG EFERVESAN TABLET, 30 ADET, REPAMEF 1/500 MG EFERVESAN TABLET, 30 ADETCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingEnfuvirtide
go.drugbank.com/drugs/DB00109ApprovedInvestigationalEnfuvirtide is a 36 amino acid biomimetic peptide that is structurally similar to the HIV proteins that are responsible for the fusion of the virus to cell membranes and subsequent intracellular uptake … The first agent in the novel class of antiretroviral drugs called HIV fusion inhibitors, enfuvirtide works by inhibiting HIV-1 fusion with CD4 cells.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 SubstratesSpermine
go.drugbank.com/drugs/DB00127InvestigationalNutraceuticalSpermine is a spermidine-derived biogenic polyamine found as a polycation at all pH values. … Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
Synonyms: N,N'-Bis(3-aminopropyl)-1,4-butanediamineAdenosine phosphate
go.drugbank.com/drugs/DB00131ApprovedInvestigationalNutraceuticalWithdrawnAdenosine phosphate, or adenylic acid, is an adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. … Adenosine phosphate was withdrawn by the FDA since it was considered neither safe nor effective for its intended uses as a vasodilator and an anti-inflammatory.[L43937]
Synonyms: Adenosine-5'P, 5'-O-PhosphonoadenosineInternational brands: My-B-DenCalcitriol
go.drugbank.com/drugs/DB00136ApprovedInvestigationalNutraceuticalD<sub>3</sub>. … Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1,25-dihydroxycholecalciferol, or 1alpha,25-dihydroxyvitamin D<sub>3</sub>, 1,25-dihydroxyvitamin
Synonyms: 1-alpha-25-Dihydroxyvitamin D3, (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triolCategories: Vitamin D and Analogues, Cytochrome P-450 SubstratesPhosphatidyl serine
go.drugbank.com/drugs/DB00144ApprovedNutraceuticalPhosphatidyl serine (PS) is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes and activates Protein … In apoptosis, phosphatidyl serine is transferred to the outer leaflet of the plasma membrane. This is part of the process by which the cell is targeted for phagocytosis.
Synonyms: PSInternational brands: LifeExtension PS CapsDaleuton
go.drugbank.com/drugs/DB00154InvestigationalNutraceuticalA 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.
Synonyms: (Z,Z,Z)-8,11,14-Icosatrienoate, (Z,Z,Z)-8,11,14-Eicosatrienoic acidNADH
go.drugbank.com/drugs/DB00157ApprovedNutraceuticalNADH is the reduced form of NAD+, and NAD+ is the oxidized form of NADH, a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. … It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).
Mixtures: Folika-V, Nutra-ZCategories: Heterocyclic Compounds, 2-Ring