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Displaying results 4321 - 4330 of 10000 in total
  1. Target

    NAD-dependent protein deacylase sirtuin-6

    go.drugbank.com/bio_entities/BE0016679
    TargetHumans

    NAD-dependent protein deacetylase, deacylase and mono-ADP-ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging (PubMed:18337721, PubMed:1...

    Polypeptides: NAD-dependent protein deacylase sirtuin-6Synonyms: SIR2-like protein 6, Regulatory protein SIR2 homolog 6
  2. Target

    Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

    go.drugbank.com/bio_entities/BE0023607
    EnzymeHumans

    Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin, a step in the uric acid degradation pathway following urate oxidation (By similarity

    Polypeptides: Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylaseSynonyms: Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
  3. Drug

    Bicalutamide

    go.drugbank.com/drugs/DB01128
    ApprovedInvestigational

    It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor.

    Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsProducts: CASODEX® 150 MG, BICAN ® 50 MG TABLETAS
  4. Drug

    Nimesulide

    go.drugbank.com/drugs/DB04743
    ApprovedInvestigationalWithdrawn

    Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. … Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.

    Mixtures: ETNA COMBO 100 MG/8 MG TABLET, 14 ADET, NİMES COMBO 100 MG / 8 MG TABLET , 14 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  5. Drug

    Brinzolamide

    go.drugbank.com/drugs/DB01194
    Approved

    [L35310,L35315] In Europe, it was also approved as a combination product with timolol in 2008.[L35320] … [A2051] Brinzolamide was approved by the FDA in 1998 as a standalone product and in 2013 as a combination product with brimonidine tartrate.

    Mixtures: BRİTİL-T 10 MG/ML + 5 MG/ML GÖZ DAMLASI, SÜSPANSİYON, 1 ADET, AZARGA 10 MG/ML + 5 MG/MLCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates
  6. Drug

    Cyanocobalamin

    go.drugbank.com/drugs/DB00115
    ApprovedInvestigationalNutraceutical

    Cyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt. … This drug was initially approved by the FDA in 1942 [FDA label].

    Mixtures: SIN SED POLVO (PARA BEBIDA HIDRATANTE VITAMINADA), ENJEKSİYONLUK ÇÖZELTİ İÇEREN AMPUL (1 ML VE 2 ML) X 6 AMPULCategories: Heterocyclic Compounds with 4 or More Rings, Vitamin B Complex
  7. Drug

    Rubella virus vaccine

    go.drugbank.com/drugs/DB10317
    ApprovedInvestigational

    It is prepared from RA 27/3 strain of live attenuated rubella virus. Rubella is a common childhood disease, caused by rubella virus (togavirus). … Rubella virus vaccine is a live attenuated virus vaccine for active immunization against rubella (German measles) that is subcutaneously administered.

    Mixtures: <p>SII MEASLES,MUMPS &amp; RUBELLA VACCINE LIVE ATTENUATED (FREEZE-DRIED) SINGLE DOSE</p>, SII Measles and Rubella Virus Vaccine live.Attenuated(Freeze-Dried) 1 doseSynonyms: Rubella virus live antigen, A, Rubella virus (vaccine strain RA27/3) live antigen
  8. Drug

    Albumin human

    go.drugbank.com/drugs/DB00062
    ApprovedInvestigational

    Human albumin is a small globular protein (molecular weight: 66.5 kDa), consisting of a single chain of 585 amino acids organized in three repeated homolog domains (sites I, II, and III). … Also known as _Albuminex_ 5% or 25%, one brand of human serum albumin is prepared from the pooled plasma of US donors in FDA-licensed facilities in the US [F229].

    Products: Pulmocis 2 mg Kit für ein radioaktives Arzneimittel, NANOTOP 0,5 mg Kit für ein radioaktives Arzneimittel
  9. Drug

    Midazolam

    go.drugbank.com/drugs/DB00683
    ApprovedIllicitInvestigational

    [A257153] Midazolam is considered a schedule IV drug in the United States due to the low potential for abuse and low risk of dependence.[L5074] … [A173842] It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action.

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: Epistatus 5 mg Lösung zur Anwendung in der Mundhöhle, MIDAZOLAM SUN
  10. Target

    Gamma-aminobutyric acid receptor subunit alpha-6

    go.drugbank.com/bio_entities/BE0000764
    TargetHumans

    Extrasynaptic alpha-6-containing receptors contribute to the tonic GABAergic inhibition. Alpha-6 subunits are also present on glutamatergic synapses (By similarity) … Alpha-6/GABRA6 subunits are found at both synaptic and extrasynaptic sites (PubMed:8632757).

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-6Synonyms: GABAAR subunit alpha-6, GABA(A) receptor subunit alpha-6