Gamma-aminobutyric acid receptor subunit alpha-6

BE0000764ProteinHumansGABRA6

Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:8632757). It is acted on by 17 drugs in DrugBank.

Gene name
GABRA6
UniProtKB entry
Q16445Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
453 residues · 51,024 Da
Also known as
GABA(A) receptor subunit alpha-6 · GABAAR subunit alpha-6

Resolves to

Protein
UniProtQ16445UniProt nameGBRA6_HUMAN
Gene
HGNCHGNC:4080NCBI Gene2559GenBank1470364GeneCardsGABRA6
Pharmacology
IUPHAR/GtoPdb409KEGGhsa:2559
Drugs

What you can answer from here — as of September 07, 2019

17DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
39+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Gamma-aminobutyric acid receptor subunit alpha-6, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In