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Nafamostat
go.drugbank.com/drugs/DB12598InvestigationalIt has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome. … Nafamostat is a synthetic serine protease inhibitor that is commonly formulated with hydrochloric acid due to its basic properties.
Synonyms: p-Guanidinobenzoic acid ester with 6-hydroxy-2-naphthamidineCrotalus scutulatus antivenin
go.drugbank.com/drugs/DB13891ApprovedSpecimens with type A venom, which cause a different pattern of injury than other rattlesnakes, have been reported in southern California, Nevada, Utah, Arizona, Texas, and New Mexico [L2856]. … CROFAB (crotalidae polyvalent immune fab (ovine))is a sheep-derived antivenin used for the management of adult and pediatric patients with North American crotalid envenomation [FDA label], which includes
Lumefantrine co-artemether
go.drugbank.com/drugs/DB13085ApprovedInvestigationalWithdrawnLumefantrine Co-Artemether (Riamet) has been investigated for the treatment of Malaria, Malaria, Falciparum, Malaria in Pregnancy, Uncomplicated Malaria, and Uncomplicated Knowlesi Malaria. … Unlike artemether, lumefantrine has a slower onset of action, resulting in clearance of residual parasites and a decrease in recrudescence rate.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesBeractant
go.drugbank.com/drugs/DB06761ApprovedIn comparison to synthetic forms of surfacant, natural forms such as Beractant have been found to have a reduced incidence of pneumothorax and reduced mortality. … SP-B and SP-C.
Products: SURVANTA ® 4 ML, SURVANTA INTRATRAKEAL SUSPANSIYON, 1 ADETErdosteine
go.drugbank.com/drugs/DB05057ApprovedInvestigationalErdosteine has been shown to be safe and well tolerated in clinical trials. … Erdosteine is a drug that causes a breakdown of mucus, also known as a _mucolytic_ agent.
Categories: Heterocyclic Compounds, 1-RingProducts: DOSTEIN® CAPSULAS, DOSTEIN® SUSPENSIONUmbralisib
go.drugbank.com/drugs/DB14989ApprovedInvestigationalWithdrawnIt was marketed as Ukoniq by TG Therapeutics and has been approved for the treatment of relapsing and refractory marginal cell lymphoma and follicular lymphoma in adults. … with a possible increased risk of death outweighing the benefits.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesAlkaline Phosphatase
go.drugbank.com/drugs/DB05768InvestigationalAlkaline Phosphatase (AP) is an oral treatment and has a very favorable side-effect profile.
CYT-6091
go.drugbank.com/drugs/DB05991ExperimentalCYT-6091 (Aurimune) is an investigational small molecule made up of recombinant human tumor necrosis factor alpha (rhTNF) and thiolyated polyethylene glycol bound to the surface of 27 nm colloidal gold particles. It was under investagtio...
Categories: Compounds used in a research, industrial, or household settingIntegrin beta-2
go.drugbank.com/bio_entities/BE0001041TargetHumansIntegrin ITGAM:ITGB2 is also a receptor for factor X. Integrin ITGAD:ITGB2 is a receptor for ICAM3 and VCAM1 (PubMed:10438935, PubMed:8777714, PubMed:9841932). … Integrin ITGAM:ITGB2/MAC-1 complex functions as a signaling receptor for the ligand receptor ICAM1, ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124).
Synonyms: Complement receptor C3 subunit betaSialic acid-binding Ig-like lectin 7
go.drugbank.com/bio_entities/BE0001648TargetHumansIn the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through
Synonyms: Adhesion inhibitory receptor molecule 1