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VH5356136
go.drugbank.com/drugs/DB33975ExperimentalVH5356136 is a small molecule drug. … VH5356136 is under investigation in clinical trial NCT07822477 (A Study to Investigate Safety, Tolerability and Pharmacokinetics of VH5356136 in Adult Participants Without HIV).
MWN117
go.drugbank.com/drugs/DB33969ExperimentalMWN117 is a small molecule drug. MWN117 is under investigation in clinical trial NCT07824804 (Phase 1 Clinical Study of MWN117 Injection in Healthy Participants and Participants With Obesity).
CM583
go.drugbank.com/drugs/DB33976ExperimentalCM583 is a small molecule drug. CM583 is under investigation in clinical trial NCT07823764 (Study of CM583 in Healthy Participants).
Patisiran
go.drugbank.com/drugs/DB14582ApprovedIt is marketed as Onpattro which is formulated as patisiran within a liposome envelope for better delivery to the liver, where transthyretin is produced. … Patisiran is a first in class short interfering RNA for the treatment of patients with polyneuropathy caused by hereditary transthyretin-mediated amyloidosis [L4220].
Categories: Compounds used in a research, industrial, or household settingRisperidone
go.drugbank.com/drugs/DB00734ApprovedInvestigationalRisperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. … [L12885] It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesInternational brands: Risperidal M-TabRiluzole
go.drugbank.com/drugs/DB00740ApprovedInvestigationalRiluzole is marketed as Rilutek by Sanofi. … A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: RILUTEK® TABLETAS X 50MG, TEGLUTIK® SUSPENSIÓN ORAL 5 MG/MLTranylcypromine
go.drugbank.com/drugs/DB00752ApprovedInvestigationalTranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. … An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: (1R*,2S*)-2-phenylcyclopropan-1-amine, (±)-trans-2-phenylcyclopropylamineIsoflurane
go.drugbank.com/drugs/DB00753ApprovedInvestigationalVet approvedA stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersSynonyms: 1-chloro-2,2,2-trifluoroethyl difluoromethyl etherBenzquinamide
go.drugbank.com/drugs/DB00767ApprovedWithdrawnBenzquinamide is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. … The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine receptors and histamine H1 receptors.
Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 2-RingAlprostadil
go.drugbank.com/drugs/DB00770ApprovedInvestigationalAlprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator produced endogenously. … for whom oral treatment is either contraindicated or ineffective.
Categories: Prostaglandins ESynonyms: PGE-1, (11α,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid