Benzquinamide

DB00767ApprovedWithdrawnSmall molecule

Benzquinamide is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine receptors...

Mechanism: The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine receptors and histamine H1 receptors.
Curator reviewed
Primary indication: Used to prevent and treat nausea and vomiting associated with anesthesia and surgery, administered intramuscularly or intravenously.Curator reviewed
Formula / weight: C₂₂H₃₂N₂O₅ · 404.4999 g/mol (avg)

Resolves to

Compound

UNII0475EA27Q3CAS63-12-7ChEMBLCHEMBL1201250ChEBI27662PubChem2342KEGGD00243

Clinical / RWD

RxNorm19041PharmGKBPA164749018

Structure

InChIKeyJSZILQVIPPROJI-UHFFFAOYSA-NSMILESCCN(CC)C(=O)C1CN2CCC3=CC(OC)=C(OC)C=C3C2CC1OC(C)=O

Targets

P35367HRH1P14416DRD2P08173CHRM4P11229CHRM1P08912CHRM5P08172CHRM2P20309CHRM3

What you can answer from here — as of September 13, 2026

7Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

524Drug interactionsStructured to mechanism, not free text

15+ReferencesStructured and connected to the statements they support

Which drugs share a target with Benzquinamide, and which of those have an active Phase 3 trial?

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