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Tocainide Action Pathway
smpdb.ca/view/SMP0000330Drug actionIt has similar electrophysiological effects as lidocaine and may be used to treat ventricular arrhythmias. … Unlike lidocaine, tocainide may be administered orally and has a long plasma half-life of 12 hours (plasma t1/2 of lidocaine = 15 30 minutes).
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Flecainide Action Pathway
smpdb.ca/view/SMP0000331Drug actioncurrents via the voltage-gated rapid delayed rectifying potassium channel (I-Kr) and blocks the extrusion of calcium ions from the sarcoplasmic reticulum (SR) to the cytosol via the cardiac ryanodine receptor
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Ibutilide Action Pathway
smpdb.ca/view/SMP0000332Drug actionIbutilide may be used to treat atrial fibrillation or atrial flutter. It may cause Torsades de Pointes in up to 6% of patients.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Diltiazem Action Pathway
smpdb.ca/view/SMP0000359Drug actionDue to its cardioselective properties, diltiazem may be used to treat arrhythmias (e.g. atrial fibrillation, atrial flutter and paroxysmal supraventrucular tachycardia) as well as hypertension.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Labetalol Action Pathway
smpdb.ca/view/SMP0000368Drug actionLabetalol (also known as Albetol or Ibidomide) is an inhibitor/antagonist of beta-1 adrenergic receptor that can be used for treating high blood pressure and reducing cardiac output. … Labetalol can bind to beta-1 adrenergic receptor on both vascular smooth muscle, which lead to inhibition of vasoconstriction in peripheral blood vessels and adrenergic stimulation of endothelial cell
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Felodipine Action Pathway
smpdb.ca/view/SMP0000377Drug actionFelodipine may be used to treat mild to moderate essential hypertension. .
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Isradipine Action Pathway
smpdb.ca/view/SMP0000378Drug actionIsradipine (also known as DynaCirc or Prescal) is a calcium channel blocker within dihydropyridine (DHP) class that can be used for treating high blood pressure and essential hypertension. There are at least 5 different types of calcium ...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Bopindolol Action Pathway
smpdb.ca/view/SMP0000657Drug actionAdrenaline (also known as epinephrine) can activate β1 adrenergic receptor so that the heart rate and output will be increased. … Bopindolol (also known as Sandonorm) is a selective β1 adrenergic receptor antagonist (beta blocker), which can be used for treatment of high blood pressure (hypertension) and irregular heartbeats
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Sotalol Action Pathway
smpdb.ca/view/SMP0000660Drug actionSotalol is a beta-adrenergic receptor antagonist, which is a treatment regimen for heart failure such as abnormal heart rhythms. … The electrophysiologic effects of sotalol may be due to its selective inhibition of the rapidly activating component of the potassium channel involved in the repolarization of cardiac cells.
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2Epinephrine Action Pathway
smpdb.ca/view/SMP0000661Drug actionEpinephrine can be derived from phenylalanine and tyrosine and it is an active sympathomimetic hormone that can be secreted from adrenal medulla. Epinephrine can stimulate alpha- and beta- adrenergic systems by binding on alpha-1 and bet...
Enzymes: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase, Ryanodine receptor 2