Search
Solute carrier family 2, facilitated glucose transporter member 2
go.drugbank.com/bio_entities/BE0001045TargetTransporterHumansLikely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism … Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197).
Polypeptides: Solute carrier family 2, facilitated glucose transporter member 2Synonyms: Glucose transporter type 2, liverSolute carrier family 2, facilitated glucose transporter member 1
go.drugbank.com/bio_entities/BE0001057CarrierTransporterTargetHumansHas a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). … Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690).
Polypeptides: Solute carrier family 2, facilitated glucose transporter member 1Synonyms: HepG2 glucose transporter, Glucose transporter type 1, erythrocyte/brainMidostaurin
go.drugbank.com/drugs/DB06595ApprovedInvestigationalMidostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potent...
Elivaldogene autotemcel
go.drugbank.com/drugs/DB16746ApprovedGene therapy with autologous hematopoietic stem cells was introduced and investigated as a possible treatment for patients with adrenoleukodystrophy. … Allogeneic hematopoietic stem-cell transplantation has been the primary treatment option; however, it is associated with a risk of graft failure and graft-versus-host disease (GVHD), calling for alternative
Betibeglogene autotemcel
go.drugbank.com/drugs/DB16900ApprovedInvestigationalBetibeglogene autotemcel is an autologous gene therapy that adds functional copies of the β-globin gene (β<sup>A-T87Q</sup>-globin) to hematopoietic stem cells in order to treat β-thalassemia. … [A251770] Patients treated with betibeglogene autotemcel are given an infusion of their own hematopoietic stem cells, previously enriched for CD34+ and transduced _ex vivo_ with BB305 LVV, a self-inactivating
Categories: Autologous Hematopoietic Stem Cell-Based Gene Therapy, Complex MixturesMenkes Disease
go.drugbank.com/conditions/DBCOND0042586Drugs: Copper histidinateSynonyms: Copper transport disease, X-linked copper deficiencyEscitalopram
go.drugbank.com/drugs/DB01175ApprovedInvestigational[A39738,A185819] Amongst SSRIs, escitalopram exerts the highest degree of selectivity for the serotonin transporter (SERT) relative to other off-targets which may explain its lower rates of adverse effects … as compared to other agents in this class.
Categories: Membrane Transport ModulatorsFolic acid
go.drugbank.com/drugs/DB00158ApprovedInvestigationalNutraceuticalVet approvedFolic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purin...
Mixtures: Se-Natal, Se-Natal 19Categories: Vitamin B Complex, ferrous amino acid complex and folic acidDisseminated mycobacterium avium complex infection
go.drugbank.com/conditions/DBCOND0025049Drugs: StreptomycinSynonyms: Disseminated Mycobacterium avium complex, Disseminated mycobacterium avium complex infectionTestosterone undecanoate
go.drugbank.com/drugs/DB13946ApprovedInvestigational[L35970,L8932,L41355] Testosterone is a critical male hormone that is responsible for the normal growth and development of the male sex organs and for the maintenance of secondary sex characteristics