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EGS21
go.drugbank.com/drugs/DB05056ExperimentalGC is a glycolipid that has been shown by Enzo scientists and collaborators to act as an anti-inflammatory agent in animal model systems, and therefore is being evaluated as an important candidate … EGS21(TM) is a beta-D-glucosylceramide (GC) compound. It is a potential therapeutic for treating immune mediated disorders.
Dasiglucagon
go.drugbank.com/drugs/DB15226Approved[L39200] Treatments for severe hypoglycemia have mostly been limited to intravenous dextrose and different glucagon formulations. … severe hypoglycemia a year.
Categories: Glucagon Receptor AgonistsSotagliflozin
go.drugbank.com/drugs/DB12713ApprovedInvestigational[L39734] A similar approval has also been sought in the US, but the FDA has since published a proposal to refuse the approval because the data submitted did not show that it was safe under the proposed … 1 diabetes mellitus (T1DM) and a BMI ≥27 kg/m<sup>2</sup>.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesVadadustat
go.drugbank.com/drugs/DB12255ApprovedInvestigationalWhile efficacious, the overuse of ESAs has been associated with cardiovascular complications, progression of CKD, and increases in overall mortality. … These transcription factors serve a multitude of roles, including the stimulation of erythropoiesis.
Categories: Cytochrome P-450 CYP2B6 Inducers, Heterocyclic Compounds, 1-RingSynonyms: Glycine, N-((5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl)carbonyl)-, N-(5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl)glycinePentaerythritol tetranitrate
go.drugbank.com/drugs/DB06154ApprovedWithdrawnIt is a pentaerythritol nitrate in which all four hydroxy groups of pentaerythritol have been converted to the corresponding nitrate ester. … When mixed with a plasticizer, this chemical forms a plastic explosive. It is recognized by the FDA to be a coronary vasodilator in the treatment of heart conditions such as angina [L2395].
Products: เพอริเตรท(R) (10 มก.)Olodaterol
go.drugbank.com/drugs/DB09080ApprovedInvestigationalSingle doses of olodaterol have been shown to improve forced expiratory volume in 1 sec (FEV1) for 24 h in patients with COPD, allowing once daily dosing. … Activation of the receptor stimulates an associated G protein which then activates adenylate cyclase, catalyzing the formation of cyclic adenosine monophosphate (cAMP) and protein kinase A (PKA).
Mixtures: SPIOLTO®RESPIMAT®, SPIOLTO®RESPIMAT®Categories: Adrenergic beta-1 Receptor Agonists, Adrenergic beta-2 Receptor AgonistsDidesmethylrocaglamide
go.drugbank.com/drugs/DB15496ExperimentalDidesmethylrocaglamide is a naturally-occurring derivative of [rocaglamide] and belongs to a class of anti-cancer phytochemicals referred to as "rocaglamides" derived from plants of the genus _Aglaia_.
Integrin alpha-X
go.drugbank.com/bio_entities/BE0009967TargetHumansFunctions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis (PubMed:16985175) … Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses.
Synonyms: Leukocyte adhesion receptor p150,95Protein S100-A6
go.drugbank.com/bio_entities/BE0002950TargetHumansMay function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such a...
Synonyms: Prolactin receptor-associated proteinClusterin
go.drugbank.com/bio_entities/BE0009055TargetHumansFunctions as extracellular chaperone that prevents aggregation of non native proteins (PubMed:11123922, PubMed:19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed:11123922, PubMed:12176985, PubMed:17260971, Pu...
Synonyms: Aging-associated gene 4 protein