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Displaying results 4411 - 4420 of 10000 in total
  1. Drug

    trans NV-04

    go.drugbank.com/drugs/DB05843
    Experimental

    trans NV-04 is a cardiovascular drug which shows a significant reduction in blood pressure and arterial stiffness.

  2. Target

    Angiopoietin-1 receptor

    go.drugbank.com/bio_entities/BE0003379
    TargetHumans

    Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding … reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence.

    Synonyms: Tyrosine kinase with Ig and EGF homology domains-2
  3. Drug

    Etifoxine

    go.drugbank.com/drugs/DB08986
    ApprovedWithdrawn

    Etifoxine is an anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s. It is used in anxiety disorders and to promote peripheral nerve healing. … It does not bind to the benzodiazepine receptor though the effects are similar to that of benzodiazepines. It is more effective than lorazepam as an anxiolytic, and has fewer side effects.

  4. Drug

    Calcium glubionate anhydrous

    go.drugbank.com/drugs/DB13142
    Approved

    Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.

    Categories: Alimentary Tract and Metabolism
  5. Drug

    Pinacidil

    go.drugbank.com/drugs/DB06762
    Approved

    Pinacidil is a cyanoguanidine drug that acts by opening ATP-sensitive potassium channels, leading to peripheral vasodilatation of arterioles and decreasing peripheral vascular resistance. … The above processes result in reduced blood pressure. This drug has been discontinued by the FDA.

    Categories: pinacidil and diuretics, Arteriolar Smooth Muscle, Agents Acting On
  6. Drug

    Quinidine barbiturate

    go.drugbank.com/drugs/DB01346
    Approved

    A papulopurpuric eruption in a patient (without thrombopenia) can be developed who is taking quinidine phenylethyl barbiturate intermittently and at reintroduction.(PMID: 9739909) … The administration of quinidine derivatives helps to observe various skin and mucosal reactions.

  7. Drug

    Fedratinib

    go.drugbank.com/drugs/DB12500
    ApprovedInvestigational

    [A183176,L8090] It is an anilinopyrimidine derivative.[A183188] Fedratinib was granted FDA approval on August 16, 2019.[L8090] … Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.

    Categories: Antineoplastic and Immunomodulating Agents, Genito Urinary System and Sex Hormones
  8. Drug

    Magnesium acetate

    go.drugbank.com/drugs/DB13996
    Approved

    Synonyms: Mg(II) acetateMixtures: Normosol-M and Dextrose, Normosol-M and Dextrose
  9. Drug

    Azimilide

    go.drugbank.com/drugs/DB04957
    Investigational

    It is not approved for use in any country, but is currently in clinical trials in the United States. … Azimilide is an investigational class III anti-arrhythmic drug that blocks fast and slow components of the delayed rectifier cardiac potassium channels.

    Categories: Calcium-Regulating Hormones and Agents
  10. Drug

    Sulfur hexafluoride

    go.drugbank.com/drugs/DB11104
    ApprovedInvestigational

    Sulfur hexafluoride is an ultrasound contrast agent indicated for use •in echocardiography to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border … in adult patients with suboptimal echocardiograms •in ultrasonography of the liver for characterization of focal liver lesions in adult and pediatric patients