Magnesium acetate

Identification

Brand Names
Normosol-M, Procalamine 3
Generic Name
Magnesium acetate
DrugBank Accession Number
DB13996
Background

Not Available

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 142.393
Monoisotopic: 142.01165037
Chemical Formula
C4H6MgO4
Synonyms
  • acetato de magnesio
  • acetic acid magnesium salt
  • Acetic acid, magnesium salt (2:1)
  • Magnesium di(acetate)
  • magnesium diacetate
  • Mg(II) acetate

Pharmacology

Indication

Not Available

Pharmacology
Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
Avoid life-threatening adverse drug events
Improve clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events & improve clinical decision support.
Learn more
Pharmacodynamics

Not Available

Mechanism of action
TargetActionsOrganism
USodium/potassium-transporting ATPase subunit alpha-1Not AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.
Learn more
Improve decision support & research outcomes with our structured adverse effects data.
Learn more
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Magnesium acetate.
AlfentanilThe therapeutic efficacy of Magnesium acetate can be decreased when used in combination with Alfentanil.
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Magnesium acetate.
AmiodaroneThe therapeutic efficacy of Magnesium acetate can be decreased when used in combination with Amiodarone.
AmlodipineThe therapeutic efficacy of Magnesium acetate can be decreased when used in combination with Amlodipine.
AtracuriumThe therapeutic efficacy of Atracurium can be increased when used in combination with Magnesium acetate.
Atracurium besylateThe therapeutic efficacy of Atracurium besylate can be increased when used in combination with Magnesium acetate.
BendroflumethiazideThe risk or severity of adverse effects can be increased when Bendroflumethiazide is combined with Magnesium acetate.
BenzhydrocodoneThe therapeutic efficacy of Magnesium acetate can be decreased when used in combination with Benzhydrocodone.
BenzthiazideThe risk or severity of adverse effects can be increased when Benzthiazide is combined with Magnesium acetate.
Interactions
Identify potential medication risks
Easily compare up to 40 drugs with our drug interaction checker.
Get severity rating, description, and management advice.
Learn more
Food Interactions
No interactions found.

Products

Products2
Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
Active Moieties
NameKindUNIICASInChI Key
Magnesium cationionicT6V3LHY83822537-22-0JLVVSXFLKOJNIY-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
AminosynMagnesium acetate (21 mg/100mL) + Alanine (448 mg/100mL) + Arginine (343 mg/100mL) + Glycine (448 mg/100mL) + Histidine (105 mg/100mL) + Isoleucine (252 mg/100mL) + Leucine (329 mg/100mL) + Lysine acetate (252 mg/100mL) + Methionine (140 mg/100mL) + Phenylalanine (154 mg/100mL) + Phosphoric acid (40 mg/100mL) + Potassium acetate (128 mg/100mL) + Proline (300 mg/100mL) + Serine (147 mg/100mL) + Sodium chloride (234 mg/100mL) + Threonine (182 mg/100mL) + Tryptophan (56 mg/100mL) + Tyrosine (31 mg/100mL) + Valine (280 mg/100mL)Injection, solutionIntravenousHospira, Inc.2011-03-232017-11-01US flag
Aminosyn 3.5% MMagnesium acetate (21 mg / 100 mL) + Alanine (448 mg / 100 mL) + Arginine (343 mg / 100 mL) + Glycine (448 mg / 100 mL) + Histidine (105 mg / 100 mL) + Isoleucine (252 mg / 100 mL) + Leucine (329 mg / 100 mL) + Lysine acetate (252 mg / 100 mL) + Methionine (140 mg / 100 mL) + Phenylalanine (154 mg / 100 mL) + Potassium acetate (128 mg / 100 mL) + Proline (300 mg / 100 mL) + Serine (147 mg / 100 mL) + Sodium chloride (234 mg / 100 mL) + Threonine (182 mg / 100 mL) + Tryptophan (56 mg / 100 mL) + Tyrosine (31 mg / 100 mL) + Valine (280 mg / 100 mL)LiquidIntravenousAbbott1980-12-311999-08-09Canada flag
FreAmine IIIMagnesium acetate (0.054 g/100mL) + Alanine (0.21 g/100mL) + Arginine (0.29 g/100mL) + Cysteine hydrochloride (0.014 g/100mL) + Glycine (0.42 g/100mL) + Histidine (0.085 g/100mL) + Isoleucine (0.21 g/100mL) + Leucine (0.27 g/100mL) + Lysine acetate (0.22 g/100mL) + Methionine (0.16 g/100mL) + Phenylalanine (0.17 g/100mL) + Phosphoric acid (0.040 g/100mL) + Potassium chloride (0.15 g/100mL) + Proline (0.34 g/100mL) + Serine (0.18 g/100mL) + Sodium acetate trihydrate (0.2 g/100mL) + Sodium chloride (0.12 g/100mL) + Threonine (0.12 g/100mL) + Tryptophan (0.046 g/100mL) + Valine (0.2 g/100mL)Injection, solutionIntravenousB. Braun Medical Inc.1971-09-242013-08-01US flag
Hyperlyte (multi-electrolyte Concentrate)Magnesium acetate (860 mg / 25 mL) + Calcium acetate (440 mg / 25 mL) + Sodium gluconate (1.09 g / 25 mL) + Potassium acetate (690 mg / 25 mL) + Potassium chloride (2.46 g / 25 mL) + Sodium acetate (2.72 g / 25 mL)LiquidIntravenousB. Braun Medical Inc.1998-09-042017-07-15Canada flag
LypholyteMagnesium acetate (860 mg / 20 mL) + Calcium acetate (440 mg / 20 mL) + Sodium gluconate (1.1 g / 20 mL) + Potassium acetate (690 mg / 20 mL) + Potassium chloride (2.5 g / 20 mL) + Sodium acetate (2.7 g / 20 mL)SolutionIntravenousPartners Health Care, Inc.1996-08-142008-01-10Canada flag
Lypholyte Multi-electrolyte Conc InjMagnesium acetate (43 mg / mL) + Calcium acetate (22 mg / mL) + Sodium gluconate (55 mg / mL) + Potassium acetate (34.5 mg / mL) + Potassium chloride (125 mg / mL) + Sodium acetate (135 mg / mL)LiquidIntravenousLyphomed, Division Of Fujisawa Canada Inc.1991-12-311996-09-10Canada flag
Normosol-M & 5% DextroseMagnesium acetate (0.021 g / 100 mL) + Dextrose, unspecified form (5 g / 100 mL) + Potassium acetate (0.128 g / 100 mL) + Sodium chloride (0.234 g / 100 mL)SolutionIntravenousIcu Medical Canada Inc1965-12-31Not applicableCanada flag
Normosol-M and DextroseMagnesium acetate (21 mg/100mL) + D-glucose monohydrate (5 g/100mL) + Potassium acetate (128 mg/100mL) + Sodium chloride (234 mg/100mL)Injection, solutionIntravenousIcu Medical Inc.2021-02-08Not applicableUS flag
Normosol-M and DextroseMagnesium acetate (21 mg/100mL) + D-glucose monohydrate (5 g/100mL) + Potassium acetate (128 mg/100mL) + Sodium chloride (234 mg/100mL)Injection, solutionIntravenousHospira, Inc.1975-08-132021-05-01US flag
NUTRIFLEX ® LIPID PERIMagnesium acetate (0.515 mg) + Alanine (3.88 mg) + Arginine (2.16 mg) + Aspartic acid (1.2 mg) + Calcium chloride dihydrate (0.353 mg) + D-glucose monohydrate (64 mg) + Glutamic acid (2.8 mg) + Glycine (1.32 mg) + Histidine (1 mg) + Isoleucine (1.872 mg) + Leucine (2.504 mg) + Lysine hydrochloride (1.816 mg) + Medium-chain triglycerides (20 mg) + Phenylalanine (2.808 mg) + Potassium acetate (2.354 mg) + Proline (2.72 mg) + Racemethionine (1.568 mg) + Serine (2.4 mg) + Sodium acetate trihydrate (0.435 mg) + Sodium chloride (0.865 mg) + Sodium hydroxide (0.64 mg) + Sodium phosphate, dibasic dihydrate (0.936 mg) + Soybean oil (20 mg) + Threonine (1.456 mg) + Tryptophan (0.456 mg) + Valine (2.08 mg) + Zinc acetate dihydrate (0.00528 mg)EmulsionIntravenousB. BRAUN MEDICAL S.A.2010-08-06Not applicableColombia flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
NutrilyteMagnesium acetate (43 mg/1mL) + Calcium acetate (22 mg/1mL) + Sodium gluconate (55 mg/1mL) + Potassium acetate (34.5 mg/1mL) + Potassium chloride (125 mg/1mL) + Sodium acetate trihydrate (135 mg/1mL)Injection, solution, concentrateIntravenousAmerican Regent1990-09-302013-05-08US flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as acetate salts. These are organic compounds containing acetic acid as its acid component.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Carboxylic acid derivatives
Direct Parent
Acetate salts
Alternative Parents
Monocarboxylic acids and derivatives / Carboxylic acids / Organic salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Acetate salt / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic oxide / Organic oxygen compound / Organic salt / Organooxygen compound
Molecular Framework
Not Available
External Descriptors
magnesium salt (CHEBI:62964)
Affected organisms
Not Available

Chemical Identifiers

UNII
0E95JZY48K
CAS number
142-72-3
InChI Key
UEGPKNKPLBYCNK-UHFFFAOYSA-L
InChI
InChI=1S/2C2H4O2.Mg/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2
IUPAC Name
magnesium(2+) diacetate
SMILES
[Mg++].CC([O-])=O.CC([O-])=O

References

General References
Not Available
ChemSpider
8556
ChEBI
62964
ChEMBL
CHEMBL1200691
Wikipedia
Magnesium_acetate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, solutionIntravenous
SolutionIntravenous
EmulsionParenteral
EmulsionIntravenous
SolutionParenteral
Injection, solution, concentrateIntravenous
LiquidIntravenous
InjectionIntravenous
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility98.2 mg/mLALOGPS
logP0.29ALOGPS
logP-0.22ChemAxon
logS-0.16ALOGPS
pKa (Strongest Acidic)4.54ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area40.13 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity23.48 m3·mol-1ChemAxon
Polarizability4.96 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Targets

Drugtargets2
Build, predict & validate machine-learning models
Use our structured and evidence-based datasets to unlock new
insights and accelerate drug research.
Learn more
Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
Learn more
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Steroid hormone binding
Specific Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates th...
Gene Name
ATP1A1
Uniprot ID
P05023
Uniprot Name
Sodium/potassium-transporting ATPase subunit alpha-1
Molecular Weight
112895.01 Da
References
  1. Buchachenko AL, Kuznetsov DA, Berdinskii VL: [New mechanisms of biological effects of electromagnetic fields]. Biofizika. 2006 May-Jun;51(3):545-52. [Article]
  2. Sirijovski N, Olsson U, Lundqvist J, Al-Karadaghi S, Willows RD, Hansson M: ATPase activity associated with the magnesium chelatase H-subunit of the chlorophyll biosynthetic pathway is an artefact. Biochem J. 2006 Dec 15;400(3):477-84. [Article]
  3. Balasubramaniyan V, Nalini N: Leptin alters brain adenosine triphosphatase activity in ethanol-mediated neurotoxicity in mice. Singapore Med J. 2006 Oct;47(10):864-8. [Article]
  4. Nogovitsina OR, Levitina EV: Neurological aspects of the clinical features, pathophysiology, and corrections of impairments in attention deficit hyperactivity disorder. Neurosci Behav Physiol. 2007 Mar;37(3):199-202. [Article]

Drug created on February 23, 2018 21:26 / Updated on June 12, 2020 16:53