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MGN-4893
go.drugbank.com/drugs/DB17338ExperimentalIn February 2011, it was granted FDA orphan designation for the treatment of polycythemia vera.[L47356]
Valiltramiprosate
go.drugbank.com/drugs/DB19191InvestigationalValiltramiprosate is under investigation in clinical trial NCT06304883 (Long-term Extension of Phase 3 Study of ALZ- 801 in APOE4/4 Early AD Subjects).
Anisomycin
go.drugbank.com/drugs/DB07374ExperimentalThis drug acts to inhibit bacterial protein and DNA synthesis.
Bermekimab
go.drugbank.com/drugs/DB14947InvestigationalBermekimab is under investigation in clinical trial NCT01384630 (Safety, Pharmacokinetics, and Efficacy of RA-18C3 in Subjects With Moderate to Severe Psoriasis).
Synonyms: RA-18C3CH-1504 L-isomer
go.drugbank.com/drugs/DB19052InvestigationalCH-1504 L-isomer is under investigation in clinical trial NCT01116141 (A Study of CH-4051 in Patients With Rheumatoid Arthritis (RA)).
Renadirsen
go.drugbank.com/drugs/DB19132InvestigationalRenadirsen is under investigation in clinical trial NCT04433234 (Long-term, Extension Study of Ds-5141b in Patients With Duchenne Muscular Dystrophy).
TAS-102
go.drugbank.com/drugs/DB08937InvestigationalTrifluridine inhibits tumor growth by being incorporated into DNA during DNA synthesis. Tipiracil prevents trifluridine from being broken down when taken orally.
Penpulimab
go.drugbank.com/drugs/DB16747ApprovedInvestigationalPenpulimab is a humanized monoclonal IgG1 antibody targeting the immune checkpoint programmed death receptor-1 (PD-1). … [A273843,A273848] Penpulimab-kcqx was approved by the US FDA in April 2025 for the treatment of nasopharyngeal carcinoma in select patients.[L52993,L52998]
Atacicept
go.drugbank.com/drugs/DB06399ApprovedInvestigationalfactor (BAFF) and A Proliferation Inducing Ligand (APRIL). … Atacicept is a recombinant fusion glycoprotein that joins the ligand-binding portion of the human TACI receptor to a modified IgG1 Fc domain, allowing it to bind and neutralize two cytokines: B cell activating
Tirbanibulin
go.drugbank.com/drugs/DB06137ApprovedInvestigationalTirbanibulin (KX-O1 or KX2–391) is a dual inhibitor of Src Kinase and tubulin. … [L27806] Actinic keratosis is a chronic condition characterized by lesions, which can potentially transform into invasive squamous cell carcinoma with a risk of 1% over 10 years.