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Biperiden
go.drugbank.com/drugs/DB00810ApprovedInvestigationalWithdrawnA muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2D6 InhibitorsSynonyms: 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol, alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropanolRosoxacin
go.drugbank.com/drugs/DB00817ApprovedRosoxacin is known to be effective against penicillin resistant strains and is a single dose orally administered drug, which avoids all complications of parenteral administration seen with penicillin, … Rosoxacin is a quinolone derivative antibiotic for the treatment of bacterial infection of respiratory tract, urinary tract, GI, CNS and immuno compromised patients.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: 1-ethyl-1,4-dihydro-4-oxo-7-(4-pyridyl)-3-quinolinecarboxylic acidCarprofen
go.drugbank.com/drugs/DB00821ApprovedVet approvedWithdrawnCarprofen is a non-steroidal anti-inflammatory drug (NSAID) that is used by veterinarians as a supportive treatment for the relief of arthritic symptoms in geriatric dogs. … It is no longer marketed for human usage, after being withdrawn on commercial grounds.
Categories: Heterocyclic Compounds, 2-Ring, Heterocyclic Compounds, 3-RingSynonyms: (+/-)-2-(3-chloro-9H-carbazol-7-yl)propanoic acid, (±)-6-chloro-α-methylcarbazole-2-acetic acidEthynodiol diacetate
go.drugbank.com/drugs/DB00823ApprovedAlthough etynodiol or ethynodiol are sometimes used as a synonym for ethynodiol diacetate, what is usually being referred to is actually ethynodiol diacetate and not ethynodiol (which is a separate drug … A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
Mixtures: Kelnor 1/35, Zovia 1/35Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesEnprofylline
go.drugbank.com/drugs/DB00824ApprovedWithdrawnEnprofylline is a derivative of theophylline which shares bronchodilator properties. … Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 3-n-propylxanthine, 3-propylxanthineBrompheniramine
go.drugbank.com/drugs/DB00835ApprovedHistamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria.
Mixtures: Rompe Pecho SF FLU, Bio T Pres-BCategories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingLoperamide
go.drugbank.com/drugs/DB00836ApprovedInvestigationalLoperamide is an anti-diarrheal agent that is available as an over-the-counter product for treating diarrhea.[L42785] The drug was first synthesized in 1969 and used medically in 1976. … [A251610] Loperamide has a chemical structure that is similar to diphenoxylate and haloperidol;[A6249] however, loperamide works on mu (μ)-opioid receptors to mediate its pharmacological actions.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: A D, Imodium A-DMethylphenobarbital
go.drugbank.com/drugs/DB00849ApprovedA barbiturate that is metabolized to phenobarbital. It has been used for similar purposes, especially in epilepsy, but there is no evidence mephobarbital offers any advantage over phenobarbital.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSynonyms: 5-ethyl-1-methyl-5-phenylbarbituric acid, 5-Ethyl-1-methyl-5-phenyl-pyrimidine-2,4,6-trioneDacarbazine
go.drugbank.com/drugs/DB00851ApprovedInvestigationalDacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic IndexSynonyms: 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide, 4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamideDiflunisal
go.drugbank.com/drugs/DB00861ApprovedDiflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. … Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis.
Categories: Non COX-2 selective NSAIDSSynonyms: 2',4'-difluoro-4-hydroxy-3-biphenylcarboxylic acid, 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acid