Search

Displaying results 441 - 450 of 10000 in total
  1. Drug

    Clotrimazole

    go.drugbank.com/drugs/DB00257
    ApprovedInvestigationalVet approved

    This drug is a broad spectrum antimycotic or antifungal agent. Clotrimazole's antimycotic properties were discovered in the late 1960s [A174094]. … As well as its antifungal activity, clotrimazole has become a drug of interest in treating several other diseases such as sickle cell disease, malaria and some cancers [A174094].

    Mixtures: TOR CREMA DERMATOLOGICA, SAEROGENTA-A CREAMCategories: Antifungals for Topical Use, Antifungals for Dermatological Use
  2. Drug

    Simvastatin

    go.drugbank.com/drugs/DB00641
    ApprovedInvestigational

    as well as the need for surgical revascularization or angioplasty following a heart attack. … events (heart attack, stroke, coronary revascularization, and coronary death) for every 1 mmol/L reduction in LDL without any significant side effects or risks.

    Categories: Hypolipidemic Agents Indicated for HyperlipidemiaProducts: Pro-simvastatin, SIMVASTATIN AL 5MG
  3. Drug

    Risperidone

    go.drugbank.com/drugs/DB00734
    ApprovedInvestigational

    which may responsible for some of its undesirable effects. … Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder.

    Products: LOST PER, Pro-risperidone
  4. Drug

    Carbinoxamine

    go.drugbank.com/drugs/DB00748
    Approved

    Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. … This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.

    Mixtures: TEMPRA XT NOCHECategories: Antihistamines for Systemic Use
  5. Drug

    Cetirizine

    go.drugbank.com/drugs/DB00341
    ApprovedInvestigational

    One of the most common uses for this drug is for a condition called _allergic rhinitis_. … Allergic rhinitis is associated with multiple missed or unproductive days at work and school, problems with sleep, and other difficulties with day to day activities for many individuals [A175057].

    Mixtures: NEXT GL GENOMMA LAB®, NEXT GL GENOMMA LAB®Categories: Antihistamines for Systemic Use
  6. Drug

    Valganciclovir

    go.drugbank.com/drugs/DB01610
    ApprovedInvestigational

    As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. … Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections.

    Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseProducts: Valganciclovir hydrochloride for Oral
  7. Drug

    Methotrexate

    go.drugbank.com/drugs/DB00563
    ApprovedInvestigational

    Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. … [A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients

    Categories: OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
  8. Target

    POU domain, class 2, transcription factor 2

    go.drugbank.com/bio_entities/BE0004865
    EnzymeTransporterHumans

    Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addi...

    Polypeptides: POU domain, class 2, transcription factor 2
  9. Target

    POU domain, class 2, transcription factor 1

    go.drugbank.com/bio_entities/BE0009712
    TransporterHumans

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription tr...

    Polypeptides: POU domain, class 2, transcription factor 1
  10. Drug

    Carbidopa

    go.drugbank.com/drugs/DB00190
    ApprovedInvestigational

    Carbidopa presents a chemical denomination of N-amino-alpha-methyl-3-hydroxy-L-tyrosine monohydrate.

    Mixtures: Pro-levocarb, Pro-levocarbCategories: Aromatic L-amino Acid Decarboxylase Inhibitors