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Lonidamine
go.drugbank.com/drugs/DB06266InvestigationalLonidamine (LND) is a drug that interferes with energy metabolism of cancer cells, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK). … In such way LND could impair energy-requiring processes, as recovery from potentially lethal damage, induced by radiation treatment and by some cytotoxic drugs.
MKC1106-PP
go.drugbank.com/drugs/DB06030ExperimentalMKC1106-PP is a 3-component investigational vaccine made up of a DNA plasmid (pPRA-PSM) and 2 peptides E-PRA and E-PSM. … MKC1106-PP was under investigation in clinical trial NCT00423254 (Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer.).
Talniflumate
go.drugbank.com/drugs/DB09295InvestigationalTalniflumate, is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma [L1400]. … Phase I trials with talniflumate for the treatment of cystic fibrosis and COPD were completed in August 2001, and phase II trials were performed in Ireland for the treatment of cystic fibrosis but this
Lysergic acid diethylamide
go.drugbank.com/drugs/DB04829IllicitInvestigationalExplanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by experimental evidence. … Some say HPPD is a manifestation of post-traumatic stress disorder, not related to the direct action of LSD on brain chemistry, and varies according to the susceptibility of the individual to the disorder
Synonyms: N,N-diethyllysergamide, N,N-diethyl-D-lysergamideCategories: Heterocyclic Compounds with 4 or More RingsAVR118
go.drugbank.com/drugs/DB04979Investigational(wasting) in patients with AIDS or cancer. … AVR118 is being studied for the promise shown in its ability to mitigate the toxic side effects of other drugs (including those used to treat HIV infection and chemotherapeutic drugs employed in the treatment
Selenomethionine
go.drugbank.com/drugs/DB11142ApprovedInvestigationalSelenomethionine is a naturally occuring amino acid in some plant materials such as cereal grains, soybeans and enriched yeast but it cannot be synthesized from animals or humans. … *In vivo*, selenomethionine plays an essential role in acting as an antioxidant, where it depletes reactive oxygen species (ROS) and aids in the formation and recycling of glutathione, another important
ATX-101
go.drugbank.com/drugs/DB05780InvestigationalATX-101 demonstrates a relative selectivity for fat over other tissues. … ATX-101 (medical), sodium deoxycholate for subcutaneous injection, is being evaluated as a treatment for the reduction of localized fat deposits.
Bempegaldesleukin
go.drugbank.com/drugs/DB15140InvestigationalBempegaldesleukin is under investigation in clinical trial NCT03729245 (A Study of NKTR-214 in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy … (Either Sunitinib or Cabozantinib Monotherapy) for Advanced Metastatic Renal Cell Carcinoma (RCC)).
ReN001
go.drugbank.com/drugs/DB05236InvestigationalReN001 a strong candidate for one of the first cell-based IND applications to be submitted to the Food and Drug Administration in the United States for consideration for the treatment of stroke in humans … ReN001 is a clonal human neural stem cell line developed for clinical use in the treatment of stable disability after stroke.
N,N,N-trimethylglycinium
go.drugbank.com/drugs/DB04455InvestigationalA naturally occurring compound that has been of interest for its role in osmoregulation. … Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)
Synonyms: N,N,N-trimethylglycinium