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Serine/threonine-protein kinase mTOR
go.drugbank.com/bio_entities/BE0002386TargetHumansof the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex ( … In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:15268862, PubMed
Synonyms: Rapamycin and FKBP12 target 1Stem-cell derived exosome vesicle products
go.drugbank.com/drugs/DB15743ExperimentalThese exosomes can also consist of VEGF and matrix metalloproteinase-9 (MMP-9) which aid in angiogenesis and tissue repair. … Once secreted into extracellular fluid, exosomes are taken up by their target cells or carried to distant target sites.
Carbon monoxide
go.drugbank.com/drugs/DB11588ApprovedInvestigationalIt is toxic to hemoglobin utilizing animals (including humans), when encountered in concentrations above about 35 ppm, although it is also formed in normal animal metabolism in low quantities, and is thought … In New Zealand, the use of carbon monoxide in fish preparation has been banned, as it may mask the effects of food spoilage and bacterial growth [L2539].
Synonyms: carbon(II) oxideFelypressin
go.drugbank.com/drugs/DB00093InvestigationalIt is a non-catecholamine vasoconstrictor used in local anaesthetic injections for dental use, and is an ingredient of preparations that have been used for treatment of pain and inflammation of the mouth … A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two
Categories: Vasopressin and Analogues, Amino Acids, Peptides, and ProteinsPonesimod
go.drugbank.com/drugs/DB12016ApprovedInvestigationalPonesimod is a selective sphingosine 1-phosphate receptor 1 modulator indicated in the treatment of relapsing forms of multiple sclerosis in adults. … [A232079] Fingolimod's activity at sphingosine 1-phosphate receptor 3 was suspected to be responsible for a portion of it's adverse effects, and so more selective modulators were developed.
Categories: Antineoplastic and Immunomodulating AgentsAlanosine
go.drugbank.com/drugs/DB05540InvestigationalAn amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities.
Categories: Amino Acids, Peptides, and Proteins, Compounds used in a research, industrial, or household settingTechnetium Tc-99m red blood cells
go.drugbank.com/drugs/DB09493ApprovedWithdrawnIt is clinically useful in early detection and localization of bleeding sites, and preoperative diagnosis of hemangioma [A32178, A32179]. … Technetium Tc-99m red blood cells is a radiopharmaceutical diagnostic agent that is intravenously administered to be used in blood pool imaging, including cardiac first pass and gated equilibrium imaging
Trichloroethylene
go.drugbank.com/drugs/DB13323ApprovedIt has been sold under a variety of trade names including Trimar and Trilene and used as a volatile anesthetic and as an inhaled obstetrical analgesic. … Trichloroethylene is a halocarbon commonly used as an industrial solvent, not to be confused with the similar 1,1,1-trichloroethane, also known as chlorothene.
Categories: Compounds used in a research, industrial, or household settingSenna leaf
go.drugbank.com/drugs/DB15889ApprovedInvestigationalSynonyms: Fan xie ye, Xia ye fan xieMixtures: Multilax 1 Cap, SENNA LEAF and DOCUSATE SODIUMMogamulizumab
go.drugbank.com/drugs/DB12498ApprovedInvestigationalApproval in Japan was granted on April 30 2012 by the Japanese Ministry of Health, Labour and Welfare for patients with relapsed or refractory CCR4-positive adult T-cell leukemia-lymphoma.[A36741] … [L4168] It was approved for the same indications in Canada in June 2022.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating Agents