This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Senna leaf is a stimulant laxative indicated in the treatment of occasional constipation.

Generic Name
Senna leaf
DrugBank Accession Number
DB15889
Background

Not Available

Type
Biotech
Groups
Approved, Experimental
Synonyms
  • Afrikanskaya senna leaf
  • Alexandria senna
  • Alexandrian senna leaf
  • Bhuikhakhasa leaf
  • Bombay senna leaf
  • Casse leaf
  • Cassia acutifolia leaf
  • Cassia alexandrina leaf
  • Cassia angustifolia leaf
  • Cassia angustifolia leaf extract
  • Cassia angustifolia vahl
  • Cassia lanceolata leaf
  • Cassia senna l.
  • Cassia senna leaf
  • Cassia senna leaf extract
  • Ennae folium
  • Fan xie ye
  • Fanxieye (cassia angustifolia)
  • Hindisana leaf
  • Indian senna leaf
  • Jalelo leaf
  • Kassiya ostrolistnaya leaf
  • Sana leaf
  • Senna
  • Senna acutifolia leaf
  • Senna alexandrina dry leaf
  • Senna alexandrina leaf
  • Senna alexandrina leaf dry extract
  • Senna alexandrina leaf extract
  • Senna alexandrina leaf powder
  • Senna angustifolia leaf
  • Senna concentrate
  • Senna leaf
  • Senna leaf (cassia angustifolia)
  • Sennae folium
  • Sennae folium (cassia angustifolia)
  • Sennae folium (senna alexandrina)
  • Sennae folium concisum
  • Standardized senna concentrate
  • Svarnapatri leaf
  • Tinnevelly senna
  • Tinnevelly senna leaf
  • True senna leaf
  • Xia ye fan xie
External IDs
  • B2056

Pharmacology

Indication

Not Available

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Associated Conditions
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Senna leaf.
AclidiniumThe therapeutic efficacy of Senna leaf can be decreased when used in combination with Aclidinium.
AlfentanilThe therapeutic efficacy of Senna leaf can be decreased when used in combination with Alfentanil.
AlloinThe risk or severity of adverse effects can be increased when Alloin is combined with Senna leaf.
AmantadineThe therapeutic efficacy of Senna leaf can be decreased when used in combination with Amantadine.
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Senna leaf.
AmiodaroneThe therapeutic efficacy of Senna leaf can be decreased when used in combination with Amiodarone.
AmitriptylineThe therapeutic efficacy of Senna leaf can be decreased when used in combination with Amitriptyline.
AmlodipineThe therapeutic efficacy of Senna leaf can be decreased when used in combination with Amlodipine.
AmobarbitalThe therapeutic efficacy of Senna leaf can be decreased when used in combination with Amobarbital.
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Food Interactions
Not Available

Products

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Gnc Natural Brand Herbal Laxative-tabTablet175 mgOralGeneral Nutrition Canada Inc.2000-08-012005-08-05Canada flag
Hermes 11 TeaLiquid100 g / 100 gOralHermes Arzneimittel Gmbh1987-12-311998-06-29Canada flag
SennaTablet250 mgOralGeneral Nutrition Canada Inc.2001-10-152005-08-05Canada flag
SennaTablet, film coated8.6 mg/1OralHIMPRIT PHARMACHEM PVT LTD2009-11-20Not applicableUS flag
Senokot GranulesPowder326 mg / 3 gOralPurdue Pharma1956-12-312007-07-13Canada flag
Senokot SuppSuppository652 mg / supRectalPurdue Pharma1964-12-312003-07-29Canada flag
X Prep Powder 3.5gmPowder3.5 g / 21.25 gOralPurdue Pharma1960-12-312003-07-29Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Bekunis DrageesSenna leaf (60 mg) + Senna leaf (20 mg) + Senna leaf (25 mg) + Bisacodyl (5 mg)TabletOralRoha Arzneimittel Gmbh1974-12-312009-07-02Canada flag
Bekunis DrageesSenna leaf (60 mg) + Senna leaf (20 mg) + Senna leaf (25 mg) + Bisacodyl (5 mg)TabletOralRoha Arzneimittel Gmbh1974-12-312009-07-02Canada flag
Bekunis DrageesSenna leaf (60 mg) + Senna leaf (20 mg) + Senna leaf (25 mg) + Bisacodyl (5 mg)TabletOralRoha Arzneimittel Gmbh1974-12-312009-07-02Canada flag
C Ottways Lax TabSenna leaf (28 mg / tab) + Aloe vera leaf (132 mg / tab) + Capsicum (19 mg / tab) + Frangula purshiana bark (28 mg / tab) + Ginger (9 mg / tab) + Glycyrrhiza glabra (28 mg / tab)TabletOralC Ottway Herbalist1950-12-311997-06-13Canada flag
CennlacsSenna leaf (726 mg / g) + Glycyrrhiza glabra (182 mg / g)PowderOralWestward Distributors1983-12-311997-05-30Canada flag
Cholasyn IISenna leaf (25 mg) + Frangula purshiana bark (175 mg)TabletOralRolmex International Inc.1983-12-312008-02-13Canada flag
EUCARBON TABLETSenna leaf (105 mg) + Activated charcoal (180 mg) + Octasulfur (50 mg) + Rhubarb (25 mg)TabletOralANTAH PHARMA SDN. BHD.2020-09-08Not applicableMalaysia flag
GeribileSenna leaf (25 mg / tab) + Frangula purshiana bark (600 mg / tab)TabletOralLes Produits Gerbex Inc.1999-02-232005-06-29Canada flag
Herba ToneSenna leaf (92 mg / 28.4 mL) + Frangula purshiana bark (85 mg / 28.4 mL) + Potassium Iodide (180 mg / 28.4 mL)LiquidOralHerbes Universelles Inc.1966-12-312009-07-15Canada flag
Herbal LaxativeSenna leaf (240 mg) + Frangula purshiana bark (150 mg)CapsuleOralNutricorp International2001-10-252009-08-05Canada flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
AK7JF626KX
CAS number
Not Available

References

General References
  1. AIFA: Tamarine (Cassia Fistula, Senna) Oral Gel [Link]
RxNav
485853

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedNot AvailableColonoscopy Preparation1
4CompletedTreatmentConstipation1
4TerminatedNot AvailableColonoscopy Preparation1
4TerminatedPreventionConstipation1
4TerminatedSupportive CareCancer / Constipation1
4Unknown StatusTreatmentConstipation / Peritoneal dialysis complication1
4WithdrawnHealth Services ResearchColorectal Cancer1
3CompletedTreatmentChronic Obstructive Pulmonary Disease (COPD) / Dyspnea1
3CompletedTreatmentConstipation2
3SuspendedTreatmentConstipation1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
TabletOral
TabletOral175 mg
LiquidOral
CapsuleOral
LiquidOral100 g / 100 g
KitOral
Tablet, film coatedOral12.5 mg
TabletOral250 mg
Tablet, film coatedOral8.6 mg/1
Tablet, film coatedOral
PowderOral326 mg / 3 g
SuppositoryRectal652 mg / sup
GelOral
PowderOral
SyrupOral
Tablet, chewableOral
For solutionOral
For solutionOral1.026 g
PowderOral
PowderOral3.5 g / 21.25 g
Granule
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at September 29, 2020 18:39 / Updated at December 01, 2021 03:27