This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Senna leaf is a stimulant laxative indicated in the treatment of occasional constipation.
- Generic Name
- Senna leaf
- DrugBank Accession Number
- DB15889
- Background
Not Available
- Type
- Biotech
- Groups
- Approved, Experimental
- Synonyms
- Afrikanskaya senna leaf
- Alexandria senna
- Alexandrian senna leaf
- Bhuikhakhasa leaf
- Bombay senna leaf
- Casse leaf
- Cassia acutifolia leaf
- Cassia alexandrina leaf
- Cassia angustifolia leaf
- Cassia angustifolia leaf extract
- Cassia angustifolia vahl
- Cassia lanceolata leaf
- Cassia senna l.
- Cassia senna leaf
- Cassia senna leaf extract
- Ennae folium
- Fan xie ye
- Fanxieye (cassia angustifolia)
- Hindisana leaf
- Indian senna leaf
- Jalelo leaf
- Kassiya ostrolistnaya leaf
- Sana leaf
- Senna
- Senna acutifolia leaf
- Senna alexandrina dry leaf
- Senna alexandrina leaf
- Senna alexandrina leaf dry extract
- Senna alexandrina leaf extract
- Senna alexandrina leaf powder
- Senna angustifolia leaf
- Senna concentrate
- Senna leaf
- Senna leaf (cassia angustifolia)
- Sennae folium
- Sennae folium (cassia angustifolia)
- Sennae folium (senna alexandrina)
- Sennae folium concisum
- Standardized senna concentrate
- Svarnapatri leaf
- Tinnevelly senna
- Tinnevelly senna leaf
- True senna leaf
- Xia ye fan xie
- External IDs
- B2056
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
- Contraindications & Blackbox Warnings
Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetazolamide The risk or severity of adverse effects can be increased when Acetazolamide is combined with Senna leaf. Aclidinium The therapeutic efficacy of Senna leaf can be decreased when used in combination with Aclidinium. Alfentanil The therapeutic efficacy of Senna leaf can be decreased when used in combination with Alfentanil. Alloin The risk or severity of adverse effects can be increased when Alloin is combined with Senna leaf. Amantadine The therapeutic efficacy of Senna leaf can be decreased when used in combination with Amantadine. Amiloride The risk or severity of adverse effects can be increased when Amiloride is combined with Senna leaf. Amiodarone The therapeutic efficacy of Senna leaf can be decreased when used in combination with Amiodarone. Amitriptyline The therapeutic efficacy of Senna leaf can be decreased when used in combination with Amitriptyline. Amlodipine The therapeutic efficacy of Senna leaf can be decreased when used in combination with Amlodipine. Amobarbital The therapeutic efficacy of Senna leaf can be decreased when used in combination with Amobarbital. 
Identify potential medication risksEasily compare up to 40 drugs with our drug interaction checker.Get severity rating, description, and management advice.Learn more - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Gnc Natural Brand Herbal Laxative-tab Tablet 175 mg Oral General Nutrition Canada Inc. 2000-08-01 2005-08-05 Canada 
Hermes 11 Tea Liquid 100 g / 100 g Oral Hermes Arzneimittel Gmbh 1987-12-31 1998-06-29 Canada Senna Tablet 250 mg Oral General Nutrition Canada Inc. 2001-10-15 2005-08-05 Canada Senna Tablet, film coated 8.6 mg/1 Oral HIMPRIT PHARMACHEM PVT LTD 2009-11-20 Not applicable US 
Senokot Granules Powder 326 mg / 3 g Oral Purdue Pharma 1956-12-31 2007-07-13 Canada Senokot Supp Suppository 652 mg / sup Rectal Purdue Pharma 1964-12-31 2003-07-29 Canada X Prep Powder 3.5gm Powder 3.5 g / 21.25 g Oral Purdue Pharma 1960-12-31 2003-07-29 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Bekunis Dragees Senna leaf (60 mg) + Senna leaf (20 mg) + Senna leaf (25 mg) + Bisacodyl (5 mg) Tablet Oral Roha Arzneimittel Gmbh 1974-12-31 2009-07-02 Canada Bekunis Dragees Senna leaf (60 mg) + Senna leaf (20 mg) + Senna leaf (25 mg) + Bisacodyl (5 mg) Tablet Oral Roha Arzneimittel Gmbh 1974-12-31 2009-07-02 Canada Bekunis Dragees Senna leaf (60 mg) + Senna leaf (20 mg) + Senna leaf (25 mg) + Bisacodyl (5 mg) Tablet Oral Roha Arzneimittel Gmbh 1974-12-31 2009-07-02 Canada C Ottways Lax Tab Senna leaf (28 mg / tab) + Aloe vera leaf (132 mg / tab) + Capsicum (19 mg / tab) + Frangula purshiana bark (28 mg / tab) + Ginger (9 mg / tab) + Glycyrrhiza glabra (28 mg / tab) Tablet Oral C Ottway Herbalist 1950-12-31 1997-06-13 Canada Cennlacs Senna leaf (726 mg / g) + Glycyrrhiza glabra (182 mg / g) Powder Oral Westward Distributors 1983-12-31 1997-05-30 Canada Cholasyn II Senna leaf (25 mg) + Frangula purshiana bark (175 mg) Tablet Oral Rolmex International Inc. 1983-12-31 2008-02-13 Canada EUCARBON TABLET Senna leaf (105 mg) + Activated charcoal (180 mg) + Octasulfur (50 mg) + Rhubarb (25 mg) Tablet Oral ANTAH PHARMA SDN. BHD. 2020-09-08 Not applicable Malaysia 
Geribile Senna leaf (25 mg / tab) + Frangula purshiana bark (600 mg / tab) Tablet Oral Les Produits Gerbex Inc. 1999-02-23 2005-06-29 Canada Herba Tone Senna leaf (92 mg / 28.4 mL) + Frangula purshiana bark (85 mg / 28.4 mL) + Potassium Iodide (180 mg / 28.4 mL) Liquid Oral Herbes Universelles Inc. 1966-12-31 2009-07-15 Canada Herbal Laxative Senna leaf (250 mg / cap) + Frangula purshiana bark (200 mg / cap) Capsule Oral Holista Health (Canada) Inc. 1997-08-26 2006-08-24 Canada
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- AK7JF626KX
- CAS number
- Not Available
References
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Completed Not Available Colonoscopy Preparation 1 4 Completed Treatment Constipation 1 4 Terminated Not Available Colonoscopy Preparation 1 4 Terminated Prevention Constipation 1 4 Terminated Supportive Care Cancer / Constipation 1 4 Unknown Status Treatment Constipation / Peritoneal dialysis complication 1 4 Withdrawn Health Services Research Colorectal Cancer 1 3 Completed Treatment Chronic Obstructive Pulmonary Disease (COPD) / Dyspnea 1 3 Completed Treatment Constipation 2 3 Suspended Treatment Constipation 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet Oral Tablet Oral 175 mg Liquid Oral Capsule Oral Liquid Oral 100 g / 100 g Kit Oral Tablet, film coated Oral 12.5 mg Tablet Oral 250 mg Tablet, film coated Oral 8.6 mg/1 Tablet, film coated Oral Powder Oral 326 mg / 3 g Suppository Rectal 652 mg / sup Gel Oral Powder Oral Syrup Oral Tablet, chewable Oral For solution Oral For solution Oral 1.026 g Powder Oral Powder Oral 3.5 g / 21.25 g Granule - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
Drug created at September 29, 2020 18:39 / Updated at December 01, 2021 03:27