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Oxaprotiline
go.drugbank.com/drugs/DB09307ExperimentalBoth enantiomers have antidepressant effects but levoprotiline also is an antihistamine and dextroprotiline has many other pharmacological actions.
Nitarsone
go.drugbank.com/drugs/DB11437ExperimentalVet approvedIt is marketed as Histostat by Zoetis, a publicly traded subsidiary of Pfizer.
Ulimorelin
go.drugbank.com/drugs/DB12128InvestigationalUlimorelin is a novel small molecule ghrelin agonist being developed by Tranzyme Pharma as a first-in-class treatment for both POI and diabetic gastroparesis, serious medical conditions in which motility
Physostigmine
go.drugbank.com/drugs/DB00981ApprovedA cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treat...
EGT-101
go.drugbank.com/drugs/DB17645ExperimentalDeveloped by Esteve Pharmaceuticals, it is being investigated for Sanfilippo syndrome type A.[L45919]
Icodextrin
go.drugbank.com/drugs/DB00702ApprovedInvestigationalIcodextrin is an iso-osmotic peritoneal dialysis solution containing glucose polymers. It is used primarily for ambulatory peritoneal dialysis (CAPD) of diabetic patients and automated peritoneal dialysis (APD) for patients with end-stag...
Tolcapone
go.drugbank.com/drugs/DB00323ApprovedInvestigationalWithdrawnTolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline ...
Agmatine
go.drugbank.com/drugs/DB08838ExperimentalIt is formed when arginine is decarboxylated by the enzyme arginine decarboxylase and is found naturally in ragweed pollen, ergot fungi, octopus muscle, herring sperm, sponges, and the mammalian brain.
Enprofylline
go.drugbank.com/drugs/DB00824ApprovedWithdrawnEnprofylline is a derivative of theophylline which shares bronchodilator properties. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and ...