Potassium sulfate
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Identification
- Summary
Potassium sulfate is an osmotic laxative used to cleanse the colon before a colonoscopy.
- Brand Names
- Suprep Bowel Prep Kit
- Generic Name
- Potassium sulfate
- DrugBank Accession Number
- DB14499
- Background
Not Available
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
- Weight
- Average: 174.259
Monoisotopic: 173.8791429 - Chemical Formula
- K2O4S
- Synonyms
- Dipotassium sulfate
- Potasio sulfato
- Potassium (as sulfate)
- Potassium sulfate
- Potassium sulphate
- Sulfato potasio
- Sulfuric acid, dipotassium salt
- External IDs
- E-515(I)
- Ins no.515(I)
- Ins-515(I)
Pharmacology
- Indication
Potassium is used to regulate hypokalemia as a primary condition or secondary to other medical conditions.
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- Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium is maintained by ion pumps in the cell membrane. The cell membrane potential created by potassium and sodium ions allows the cell generate an action potential—a "spike" of electrical discharge. The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle contraction, and heart function. Potassium is also an essential mineral needed to regulate water balance, blood pressure and levels of acidity.
Target Actions Organism USodium/potassium-transporting ATPase subunit alpha-1 Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Mostly urine but also skin and feces.
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Abacavir may decrease the excretion rate of Potassium sulfate which could result in a higher serum level. Acebutolol Potassium sulfate may increase the hyperkalemic activities of Acebutolol. Aceclofenac Potassium sulfate may increase the hyperkalemic activities of Aceclofenac. Acemetacin Potassium sulfate may increase the hyperkalemic activities of Acemetacin. Acetaminophen Acetaminophen may decrease the excretion rate of Potassium sulfate which could result in a higher serum level. - Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Active Moieties
Name Kind UNII CAS InChI Key Potassium cation ionic 295O53K152 24203-36-9 NPYPAHLBTDXSSS-UHFFFAOYSA-N Sulfate ion ionic 7IS9N8KPMG 14808-79-8 QAOWNCQODCNURD-UHFFFAOYSA-L - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image BLACKMORES EXECUTIVE B TABLET Potassium sulfate (75 mg) + Ascorbic acid (180 mg) + Biotin (50 µg) + Cyanocobalamin (10 µg) + Folic acid (200 mcg) + Magnesium phosphate (175 mg) + Nicotinamide (60 mg) + Pantothenic acid (20 mg) + Pyridoxine hydrochloride (10 mg) + Riboflavin (8.5 mg) + Thiamine mononitrate (7.5 mg) + Zinc sulfate (15 mg) Tablet Oral BLACKMORES (MALAYSIA) SDN. BHD. 2020-09-08 Not applicable Malaysia ColPrep Kit Potassium sulfate (3.13 g/22.7g) + Magnesium sulfate (1.6 g/22.7g) + Sodium sulfate decahydrate (17.5 g/22.7g) Powder, for solution Oral KVK-Tech, Inc. 2016-12-27 2019-01-24 US Flex Capsules Potassium sulfate (50 mg / cap) + Calcium ascorbate (35 mg / cap) + Magnesium sulfate (17 mg / cap) Capsule Oral Foodscience Laboratories, Division Of Foodscience Corporation 1998-07-02 2006-06-16 Canada IZINOVA Potassium sulfate (3.13 g/176mL) + Magnesium sulfate heptahydrate (3.276 g/176mL) + Sodium sulfate (17.51 g/176mL) Solution, concentrate Oral Mayoly Pharmaceuticals Italia S.R.L. 2014-07-08 Not applicable Italy IZINOVA Potassium sulfate (3.13 g/176mL) + Magnesium sulfate heptahydrate (3.276 g/176mL) + Sodium sulfate (17.51 g/176mL) Solution, concentrate Oral Mayoly Pharmaceuticals Italia S.R.L. 2015-05-20 Not applicable Italy
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as alkali metal sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is an alkali metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Alkali metal oxoanionic compounds
- Sub Class
- Alkali metal sulfates
- Direct Parent
- Alkali metal sulfates
- Alternative Parents
- Inorganic salts / Inorganic oxides
- Substituents
- Alkali metal sulfate / Inorganic oxide / Inorganic salt
- Molecular Framework
- Not Available
- External Descriptors
- potassium salt (CHEBI:32036)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 1K573LC5TV
- CAS number
- 7778-80-5
- InChI Key
- OTYBMLCTZGSZBG-UHFFFAOYSA-L
- InChI
- InChI=1S/2K.H2O4S/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2
- IUPAC Name
- dipotassium sulfate
- SMILES
- [K+].[K+].[O-]S([O-])(=O)=O
References
- General References
- Not Available
- External Links
- KEGG Compound
- C13192
- ChemSpider
- 22915
- ChEBI
- 32036
- ChEMBL
- CHEMBL2021424
- Wikipedia
- Potassium_sulfate
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Completed Not Available Bowel preparation therapy 1 somestatus stop reason just information to hide Not Available Unknown Status Diagnostic Inpatient Colonoscopy / Oral Sulfate Solution / Polyethelene Glycol 1 somestatus stop reason just information to hide Not Available Withdrawn Screening Colorectal Cancer 1 somestatus stop reason just information to hide 4 Completed Treatment Bowel preparation therapy / Colonoscopy / Endoscopy 1 somestatus stop reason just information to hide 4 Enrolling by Invitation Diagnostic Colonoscopy: Bowel Preparation 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Tablet Oral Powder, for solution Oral Capsule Oral Tablet, effervescent Oral Capsule, liquid filled Oral Solution Oral Kit Oral Solution, concentrate Oral - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US6946149 No 2005-09-20 2023-03-07 US
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP -0.84 Chemaxon pKa (Strongest Acidic) -3 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 80.26 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 11.53 m3·mol-1 Chemaxon Polarizability 5.81 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 106.221375 predictedDeepCCS 1.0 (2019) [M+H]+ 109.004105 predictedDeepCCS 1.0 (2019) [M+Na]+ 118.2904 predictedDeepCCS 1.0 (2019)
Targets
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:29499166, PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity)
- Specific Function
- ATP binding
- Gene Name
- ATP1A1
- Uniprot ID
- P05023
- Uniprot Name
- Sodium/potassium-transporting ATPase subunit alpha-1
- Molecular Weight
- 112895.01 Da
References
- Silva E, Gomes P, Soares-da-Silva P: Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing. J Membr Biol. 2006;212(3):163-75. Epub 2007 Feb 28. [Article]
- Li C, Geering K, Horisberger JD: The third sodium binding site of Na,K-ATPase is functionally linked to acidic pH-activated inward current. J Membr Biol. 2006;213(1):1-9. Epub 2007 Mar 8. [Article]
- Stanely Mainzen Prince P, Karthick M: Preventive effect of rutin on lipids, lipoproteins, and ATPases in normal and isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxicol. 2007;21(1):1-6. [Article]
- Simon WA, Herrmann M, Klein T, Shin JM, Huber R, Senn-Bilfinger J, Postius S: Soraprazan: setting new standards in inhibition of gastric acid secretion. J Pharmacol Exp Ther. 2007 Jun;321(3):866-74. Epub 2007 Mar 16. [Article]
- Iannello S, Milazzo P, Belfiore F: Animal and human tissue Na,K-ATPase in normal and insulin-resistant states: regulation, behaviour and interpretative hypothesis on NEFA effects. Obes Rev. 2007 May;8(3):231-51. [Article]
Drug created at July 11, 2018 16:29 / Updated at February 21, 2021 18:54