Potassium sulfate

Identification

Summary

Potassium sulfate is an osmotic laxative used to cleanse the colon before a colonoscopy.

Brand Names
Suprep Bowel Prep Kit
Generic Name
Potassium sulfate
DrugBank Accession Number
DB14499
Background

Not Available

Type
Small Molecule
Groups
Approved, Investigational
Structure
Thumb
Weight
Average: 174.259
Monoisotopic: 173.8791429
Chemical Formula
K2O4S
Synonyms
  • Dipotassium sulfate
  • Potasio sulfato
  • Potassium (as sulfate)
  • Potassium sulfate
  • Potassium sulphate
  • Sulfato potasio
  • Sulfuric acid, dipotassium salt
External IDs
  • E-515(I)
  • Ins no.515(I)
  • Ins-515(I)

Pharmacology

Indication

Potassium is used to regulate hypokalemia as a primary condition or secondary to other medical conditions.

Pharmacology
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Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Not Available

Mechanism of action

Potassium is the major cation (positive ion) inside animal cells, while sodium is the major cation outside animal cells. The concentration differences of these charged particles causes a difference in electric potential between the inside and outside of cells, known as the membrane potential. The balance between potassium and sodium is maintained by ion pumps in the cell membrane. The cell membrane potential created by potassium and sodium ions allows the cell generate an action potential—a "spike" of electrical discharge. The ability of cells to produce electrical discharge is critical for body functions such as neurotransmission, muscle contraction, and heart function. Potassium is also an essential mineral needed to regulate water balance, blood pressure and levels of acidity.

TargetActionsOrganism
USodium/potassium-transporting ATPase subunit alpha-1Not AvailableHumans
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Mostly urine but also skin and feces.

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirAbacavir may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
AcebutololPotassium sulfate may increase the hyperkalemic activities of Acebutolol.
AceclofenacPotassium sulfate may increase the hyperkalemic activities of Aceclofenac.
AcemetacinPotassium sulfate may increase the hyperkalemic activities of Acemetacin.
AcetaminophenAcetaminophen may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Potassium sulfate.
Acetylsalicylic acidPotassium sulfate may increase the hyperkalemic activities of Acetylsalicylic acid.
AclidiniumThe therapeutic efficacy of Potassium sulfate can be decreased when used in combination with Aclidinium.
AcrivastineAcrivastine may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
AcyclovirAcyclovir may decrease the excretion rate of Potassium sulfate which could result in a higher serum level.
Interactions
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Food Interactions
No interactions found.

Products

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Active Moieties
NameKindUNIICASInChI Key
Potassium cationionic295O53K15224203-36-9NPYPAHLBTDXSSS-UHFFFAOYSA-N
Sulfate ionionic7IS9N8KPMG14808-79-8QAOWNCQODCNURD-UHFFFAOYSA-L
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
ColPrep KitPotassium sulfate (3.13 g/22.7g) + Magnesium sulfate (1.6 g/22.7g) + Sodium sulfate decahydrate (17.5 g/22.7g)Powder, for solutionOralKVK-Tech, Inc.2016-12-272019-01-24US flag
NUTRAGESTA ®Potassium sulfate (18 mg) + Calcium carbonate (300 mg) + Cholecalciferol (0.44 mg) + Cobaltous sulfate heptahydrate (0.24 mg) + Cupric sulfate (2.517 mg) + Cyanocobalamin (1.15 mg) + Folic acid (1 mg) + Iron (95.4762 mg) + Magnesium sulfate (71 mg) + Manganese sulfate (3.1 mg) + Nicotinamide (8.189 mg) + Omega-3 fatty acids (555.56 mg) + Calcium pantothenate (17.5 mg) + Pyridoxine hydrochloride (1.05 mg) + Riboflavin (2.2 mg) + Sodium ascorbate (47.2879 mg) + Sodium fluoride (0.2 mg) + Sodium molybdate (0.1107 mg) + Thiamine (2.5 mg) + Vitamin A palmitate (3.3 mg) + Vitamin E (10.5 mg) + Zinc oxide (0.25 mg)Capsule, liquid filledOralPROCAPS S.A.2017-08-23Not applicableColombia flag
Sodium Sulfate, Potassium Sulfate, Magnesium SulfatePotassium sulfate (3.13 g/177mL) + Magnesium sulfate (1.6 g/177mL) + Sodium sulfate decahydrate (17.5 g/177mL)SolutionOralNovel Laboratories, Inc.2017-02-23Not applicableUS flag
SuclearPotassium sulfate (3.13 g/1mL) + Magnesium sulfate (1.6 g/1mL) + Polyethylene glycol (210 g/2L) + Potassium chloride (0.74 g/2L) + Sodium bicarbonate (2.86 g/2L) + Sodium chloride (5.60 g/2L) + Sodium sulfate decahydrate (17.5 g/1mL)KitOralBraintree Laboratories2013-01-182016-08-31US flag
SUPREP Bowel PrepPotassium sulfate (2.35 g/133.1mL) + Magnesium sulfate (1.2 g/133.1mL) + Sodium sulfate decahydrate (13.13 g/133.1mL)Solution, concentrateOralBraintree Laboratories, Inc.2010-08-05Not applicableUS flag
SUPREP Bowel PrepPotassium sulfate (3.13 g/1mL) + Magnesium sulfate (1.6 g/1mL) + Sodium sulfate decahydrate (17.5 g/1mL)Solution, concentrateOralBraintree Laboratories, Inc.2010-08-05Not applicableUS flag
TUGALPotassium sulfate (8 mg) + Ascorbic acid (42 mg) + Calcium carbonate (120 mg) + Cholecalciferol (440 IU) + Cobaltous sulfate heptahydrate (50 mcg) + Cupric sulfate (1 mg) + Cyanocobalamin (1.15 IU) + Doconexent (300 mg) + Ferrous bisglycinate (19 mg) + Folic acid (1 mg) + Icosapent (25 mg) + Magnesium sulfate (14 mg) + Manganese (1 mg) + Nicotinamide (8.189 mg) + Pantothenic acid (17.5 mg) + Pyridoxine hydrochloride (1.05 mg) + Riboflavin (2.2 mg) + Sodium fluoride (90 mcg) + Sodium molybdate (51 mcg) + Thiamine mononitrate (2.5 mg) + Vitamin A palmitate (5610 IU) + Vitamin E (10.5 IU) + Zinc oxide (0.2 mg)Capsule, liquid filledOralPROCAPS S.A.2017-09-28Not applicableColombia flag
VINATAL DHA CAPSULA DE GELATINA BLANDAPotassium sulfate (8 mg) + Ascorbic acid (42 mg) + Calcium carbonate (120 mg) + Cholecalciferol (440 IU) + Cobaltous sulfate heptahydrate (50 mcg) + Cupric sulfate pentahydrate (1 mg) + Cyanocobalamin (1.15 mcg) + Doconexent (300 mg) + Ferrous bisglycinate (19 mg) + Fish oil (25 mg) + Folic acid (1 mg) + Magnesium sulfate (14 mg) + Manganese (1 mg) + Nicotinamide (8.189 mg) + Calcium pantothenate (17.5 mg) + Pyridoxine hydrochloride (1.05 mg) + Riboflavin (2.2 mg) + Sodium fluoride (90 mcg) + Sodium molybdate dihydrate (51 mcg) + Thiamine mononitrate (2.5 mg) + Vitamin A palmitate (5610 IU) + Vitamin E (10.5 IU) + Zinc oxide (0.2 mg)Capsule, liquid filledOralPROCAPS S.A.2018-05-24Not applicableColombia flag
VIPLENA CÁPSULASBLANDASPotassium sulfate (18 mg) + Calcium carbonate (300 mg) + Cholecalciferol (0.44 mg) + Cobaltous sulfate heptahydrate (0.24 mg) + Cupric sulfate (2.517 mg) + Cyanocobalamin (1.15 mcg) + Folic acid (1 mg) + Iron (95.4762 mg) + Magnesium sulfate (71 mg) + Manganese (3.1 mg) + Nicotinamide (8.189 mg) + Omega-3 fatty acids (555.56 mg) + Pantothenic acid (17.5 mg) + Pyridoxine hydrochloride (1.05 mg) + Riboflavin (2.2 mg) + Sodium ascorbate (47.7928 mg) + Sodium fluoride (0.2 mg) + Sodium molybdate (0.1107 mcg) + Thiamine mononitrate (2.5 mg) + Vitamin A palmitate (3.3 mg) + Vitamin E (10.5 mg) + Zinc oxide (0.25 mg)Capsule, liquid filledOralPROCAPS S.A.2010-10-262018-09-20Colombia flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as alkali metal sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is an alkali metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkali metal oxoanionic compounds
Sub Class
Alkali metal sulfates
Direct Parent
Alkali metal sulfates
Alternative Parents
Inorganic salts / Inorganic oxides
Substituents
Alkali metal sulfate / Inorganic oxide / Inorganic salt
Molecular Framework
Not Available
External Descriptors
potassium salt (CHEBI:32036)
Affected organisms
Not Available

Chemical Identifiers

UNII
1K573LC5TV
CAS number
7778-80-5
InChI Key
OTYBMLCTZGSZBG-UHFFFAOYSA-L
InChI
InChI=1S/2K.H2O4S/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2
IUPAC Name
dipotassium sulfate
SMILES
[K+].[K+].[O-]S([O-])(=O)=O

References

General References
Not Available
KEGG Compound
C13192
ChemSpider
22915
ChEBI
32036
ChEMBL
CHEMBL2021424
Wikipedia
Potassium_sulfate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentBowel preparation therapy / Colonoscopy / Endoscopy1
4Unknown StatusDiagnosticColonoscopy1
3CompletedOtherDigestive System Diseases1
3CompletedTreatmentHealthy Subjects (HS)1
Not AvailableCompletedNot AvailableBowel preparation therapy1
Not AvailableNot Yet RecruitingDiagnosticInpatient Colonoscopy / Oral Sulfate Solution / Polyethelene Glycol1
Not AvailableWithdrawnScreeningColorectal Carcinoma (CRC)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
TabletOral
Powder, for solutionOral
Capsule, liquid filledOral
CapsuleOral
SolutionOral
KitOral
Solution, concentrateOral
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US6946149No2005-09-202023-03-07US flag

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.84ChemAxon
pKa (Strongest Acidic)-3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area80.26 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity11.53 m3·mol-1ChemAxon
Polarizability5.81 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Targets

Drugtargets2
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Kind
Protein
Organism
Humans
Pharmacological action
Unknown
General Function
Steroid hormone binding
Specific Function
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates th...
Gene Name
ATP1A1
Uniprot ID
P05023
Uniprot Name
Sodium/potassium-transporting ATPase subunit alpha-1
Molecular Weight
112895.01 Da
References
  1. Silva E, Gomes P, Soares-da-Silva P: Overexpression of Na(+)/K (+)-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing. J Membr Biol. 2006;212(3):163-75. Epub 2007 Feb 28. [Article]
  2. Li C, Geering K, Horisberger JD: The third sodium binding site of Na,K-ATPase is functionally linked to acidic pH-activated inward current. J Membr Biol. 2006;213(1):1-9. Epub 2007 Mar 8. [Article]
  3. Stanely Mainzen Prince P, Karthick M: Preventive effect of rutin on lipids, lipoproteins, and ATPases in normal and isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxicol. 2007;21(1):1-6. [Article]
  4. Simon WA, Herrmann M, Klein T, Shin JM, Huber R, Senn-Bilfinger J, Postius S: Soraprazan: setting new standards in inhibition of gastric acid secretion. J Pharmacol Exp Ther. 2007 Jun;321(3):866-74. Epub 2007 Mar 16. [Article]
  5. Iannello S, Milazzo P, Belfiore F: Animal and human tissue Na,K-ATPase in normal and insulin-resistant states: regulation, behaviour and interpretative hypothesis on NEFA effects. Obes Rev. 2007 May;8(3):231-51. [Article]

Drug created on July 11, 2018 16:29 / Updated on February 21, 2021 18:54