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Propacetamol
go.drugbank.com/drugs/DB09288InvestigationalPropacetamol is a non-opioid analgesic devoid of the major contraindications. … Propacetamol is a parenteral formulation of paracetamol and thus, it is a prodrug that is completely hydrolyzed to paracetamol.
Categories: Non COX-2 selective NSAIDS, Cytochrome P-450 SubstratesXTL-6865
go.drugbank.com/drugs/DB06058InvestigationalIt is being developed to prevent HCV re-infection following a liver transplant and for the treatment of chronic HCV disease. … XTL-6865 is a combination of two fully human monoclonal antibodies (Ab68 and Ab65) against the hepatitis C virus E2 envelope protein.
Voxilaprevir
go.drugbank.com/drugs/DB12026ApprovedInvestigationalHCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients [L852]. … Vosevi is approved for the treatment of adult patients with chronic HCV infection with genotype 1, 2, 3, 4, 5, or 6 infection [FDA Label].
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesDihydroxymethoxychalcone
go.drugbank.com/drugs/DB14122InvestigationalCardamonin (also known as Dihydroxymethoxychalcone), as shown by the increasing number of publications, has received growing attention from the scientific community due to the expectations toward its benefits … to human health.
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingSynonyms: (E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-oneAllogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells
go.drugbank.com/drugs/DB15731InvestigationalORBCEL-C™ is the trade name of a product composed of highly purified stromal cells derived from the human umbilical cord. … Regarding the modifications of these UC-MSCs, CD362, also known as syndecan-2, is a surface marker identified on MSCs with enhanced clonogenicity and immunomodulatory properties.
Synonyms: ORBCEL C™, Orbcel-CSitaxentan
go.drugbank.com/drugs/DB06268ApprovedWithdrawnSitaxentan was marketed under the trade name Thelin for the treatment of pulmonary arterial hypertension (PAH) by Encysive Pharmaceuticals until Pfizer purchased Encysive in February 2008. … In 2010, Pfizer voluntarily removed sitaxentan from the market over concerns of hepatotoxicity.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 InhibitorsEncainide
go.drugbank.com/drugs/DB01228ApprovedWithdrawnThe manufacturer of Enkaid capsules voluntarily withdrew the product from the US market on December 16, 1991. … Encainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack.
Categories: Antiarrhythmics, Class I, Cytochrome P-450 SubstratesSynonyms: (±)-2'-[2-(1-methyl-2-piperidyl)ethyl]-p-anisanilide, (±)-4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamideMethylprednisolone
go.drugbank.com/drugs/DB00959ApprovedInvestigationalVet approvedMethylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone].[A188811] It was first described in the literature in the late 1950s. … [A192813] The efficacy of methylprednisolone in novel coronavirus pneumonia is being investigated further in clinical trials.[L12666]
Mixtures: P-Care D80, P-Care D40Categories: P-glycoprotein inducers, P-glycoprotein substratesCyclizine
go.drugbank.com/drugs/DB01176ApprovedWithdrawnA histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
Mixtures: Echnatol B 6 - DrageesCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2C9 InhibitorsNonoxynol-9
go.drugbank.com/drugs/DB06804ApprovedWithdrawnIt is the most commonly used spermicidal contraceptive in the UK and the USA. In several European countries, spermicides are no longer on the market. … N-9 has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and condom lubricants.
Categories: Compounds used in a research, industrial, or household settingSynonyms: Nonoxynol 9, Nonoxynol-9