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Displaying results 4661 - 4670 of 10000 in total
  1. Drug

    Varenicline

    go.drugbank.com/drugs/DB01273
    ApprovedInvestigational

    In addition it acts on alpha3/beta4 and weakly on alpha3beta2 and alpha6-containing receptors. A full agonism was displayed on alpha7-receptors. On March 9, 2015, the U.S. … Specifically, varenicline is a partial agonist of the alpha4/beta2 subtype of the nicotinic acetylcholine receptor.

    Mixtures: CHAMPIX 0,5 MG 1 MG FILM KAPLI TABLET, 11 VE 14 ADET, CHAMPIX 0,5 MG 1 MG FILM KAPLI TABLET, 11 VE 14 ADETCategories: Heterocyclic Compounds, 2-Ring, Drugs Used in Addictive Disorders
  2. Drug

    Vortioxetine

    go.drugbank.com/drugs/DB09068
    ApprovedInvestigational

    receptor, an agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. … It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin

    Categories: Heterocyclic Compounds, 1-Ring, Serotonin 5-HT1 Receptor AgonistsProducts: KELAC 5 MG, FONKSERA 5 MG FILM KAPLI TABLET, 14 ADET
  3. Drug

    Prasugrel

    go.drugbank.com/drugs/DB06209
    ApprovedInvestigational

    Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. … Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine.

    Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesProducts: PRASUGREL BETA 5 MG FTA, Prasulan 5 mg-Filmtabletten
  4. Drug

    Sitagliptin

    go.drugbank.com/drugs/DB01261
    ApprovedInvestigational

    Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256 … Sitagliptin was granted FDA approval on October 16, 2006[L6061].

    Mixtures: SITAGLIPTIN E METFORMINA GALENICUM, SITAGLIPTIN E METFORMINA GALENICUMCategories: Heterocyclic Compounds, 1-Ring, Drugs Used in Diabetes
  5. Drug

    Hydrochlorothiazide

    go.drugbank.com/drugs/DB00999
    ApprovedInvestigationalVet approved

    [L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.[L8444] … [A185138] It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.

    Mixtures: Nu-amilzide 5/50 Mg Tab, Ramipril/Amlodipin/HCT 1A Pharma 5 mg/5 mg/25 mg – HartkapselnCategories: Heterocyclic Compounds, 2-Ring
  6. Drug

    Adalimumab

    go.drugbank.com/drugs/DB00051
    ApprovedInvestigational

    It is produced by recombinant DNA technology using a mammalian cell expression system. … A high-concentration, citrate-free formulation of Cyltezo® (adalimumab-adbm), a biosimilar to Humira®, was approved by the FDA in May 2024 for the treatment of multiple chronic inflammatory diseases.

    International brands: Humira PenProducts: AMGEVITA 40 MG ILO I E PEN, AMGEVITA 40MG ILO I E PEN
  7. Drug

    Anvatabart opadotin

    go.drugbank.com/drugs/DB18290
    Investigational

    Synonyms: ; conjugated at two engineered sites via a stable, F (pAF) (121), K120 (217) (121- 218), hinge 1-15 (219
  8. Drug

    Felbamate

    go.drugbank.com/drugs/DB00949
    Approved

    Alternatively, it is used to treat partial and generalized seizures associated with Lennox-Gastaut syndrome in children. It has a weak inhibitory effect on GABA receptor binding sites. … Felbamate is an anticonvulsant drug used in the treatment of epilepsy. In particular, in the adult patient population, it can be employed to treat partial seizures (with and without generalization).

    Synonyms: Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester, 2-phenyl-1,3-propanediol dicarbamateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers
  9. Drug

    Giloralimab

    go.drugbank.com/drugs/DB18862
    Investigational

    Giloralimab is under investigation in clinical trial NCT04807972 (Study to Evaluate Adverse Events and Change in Disease Activity When Intravenous (IV) Infusion of ABBV-927 Is Administered in Combination … With IV Modified FOLFIRINOX (Mffx) With or Without IV Budigalimab Compared to Mffx in Adult Participants With Untreated Pancreatic Cancer Metastasis).

    Synonyms: Immunoglobulin g1, anti-(human cd40 antigen) (human-mus musculus monoclonal pr-1614645 .gamma.1-chain), disulfide with human-mus musculus monoclonal pr-1614645 .kappa.-chain, dimer
  10. Drug

    Teicoplanin

    go.drugbank.com/drugs/DB06149
    ApprovedInvestigationalWithdrawn

    All teicoplanins share a same glycopeptide core, teicoplanin A3-1, but differ in the length and conformation of side chains attached to their β-D-glucosamine moiety. … Teicoplanin is a glycopeptide antibiotic consisting of a mixture of several compounds, five major (named teicoplanin A2-1 through A2-5) and four minor (named teicoplanin RS-1 through RS-4).

    Products: TARGOCID 200 MG/3 ML IM/IV ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ VE ÇÖZÜCÜ, 1 ADET, TARGOCID 400 MG/3 ML IM/IV ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ VE ÇÖZÜCÜ, 1 ADET