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Angiotensin II
go.drugbank.com/drugs/DB11842ApprovedInvestigationalin the inpatient setting and affects up to one third of patients in the intensive care unit, the FDA determined that there is a need for treatment options for critically ill hypotensive patients who do
Iptacopan
go.drugbank.com/drugs/DB16200ApprovedInvestigationalDue to this mutation, all progeny erythrocytes will lack the glycosyl phosphatidylinositol–anchored proteins that normally anchor 2 membrane proteins, CD55 and CD59, that protect blood cells against the
Inakalant
go.drugbank.com/drugs/DB20424InvestigationalInakalant has a monoisotopic molecular weight of 446.25 Da.
Nalorphine
go.drugbank.com/drugs/DB11490ExperimentalVet approvedIt acts at two opioid receptors—at the mu receptor it has antagonistic effects, and at the kappa receptors it exerts high-efficacy agonistic characteristics.
Alteminostat
go.drugbank.com/drugs/DB19620InvestigationalAlteminostat has a monoisotopic molecular weight of 492.28 Da.
Gemilukast
go.drugbank.com/drugs/DB19882InvestigationalGemilukast has a monoisotopic molecular weight of 601.26 Da.
Idetrexed
go.drugbank.com/drugs/DB21469InvestigationalIdetrexed has a monoisotopic molecular weight of 647.22 Da.
Alaproclate
go.drugbank.com/drugs/DB13233ExperimentalDevelopment was discontinued due to concerns over hepatotoxicity observed in animal studies.
L-aminocarnityl-succinyl-leucyl-argininal-diethylacetal
go.drugbank.com/drugs/DB06124ExperimentalC-101, also called Myodur, is developed for the treatment of Duchenne’s muscular dystrophy (DMD) which is a morbid genetic disease that can lead to death in late adolescence due to accelerated skeletal
Acadesine
go.drugbank.com/drugs/DB04944InvestigationalAcadesine has been granted Orphan Drug Designation for B-CLL in the EU.