Nalorphine
Star0
This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Nalorphine
- DrugBank Accession Number
- DB11490
- Background
Nalorphine is a mixed opioid agonist–antagonist. It acts at two opioid receptors—at the mu receptor it has antagonistic effects, and at the kappa receptors it exerts high-efficacy agonistic characteristics. It is used to reverse opioid overdose and (starting in the 1950s) in a challenge test to determine opioid dependence.
- Type
- Small Molecule
- Groups
- Experimental, Vet approved
- Structure
- Weight
- Average: 311.381
Monoisotopic: 311.15214354 - Chemical Formula
- C19H21NO3
- Synonyms
- Nalorfina
- Nalorphine
- Nalorphinum
Pharmacology
- Indication
Used to reverse opioid overdose.
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAlfentanil The therapeutic efficacy of Alfentanil can be decreased when used in combination with Nalorphine. Benzhydrocodone The therapeutic efficacy of Benzhydrocodone can be decreased when used in combination with Nalorphine. Buprenorphine The therapeutic efficacy of Buprenorphine can be decreased when used in combination with Nalorphine. Butorphanol The therapeutic efficacy of Butorphanol can be decreased when used in combination with Nalorphine. Codeine The therapeutic efficacy of Codeine can be decreased when used in combination with Nalorphine. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Product Ingredients
Ingredient UNII CAS InChI Key Nalorphine hydrochloride 9FPE56Z2TW 57-29-4 NAHATSPWSULUAA-ZQGPYOJVSA-N
Categories
- ATC Codes
- V03AB02 — Nalorphine
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic.
- Kingdom
- Organic compounds
- Super Class
- Alkaloids and derivatives
- Class
- Morphinans
- Sub Class
- Not Available
- Direct Parent
- Morphinans
- Alternative Parents
- Phenanthrenes and derivatives / Tetralins / Coumarans / Aralkylamines / Alkyl aryl ethers / 1-hydroxy-2-unsubstituted benzenoids / Piperidines / Trialkylamines / Secondary alcohols / Oxacyclic compounds show 3 more
- Substituents
- 1-hydroxy-2-unsubstituted benzenoid / Alcohol / Alkyl aryl ether / Amine / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Coumaran / Ether show 15 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- morphinane alkaloid (CHEBI:7458)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- U59WB2WRY2
- CAS number
- 62-67-9
- InChI Key
- UIQMVEYFGZJHCZ-SSTWWWIQSA-N
- InChI
- InChI=1S/C19H21NO3/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20/h2-6,12-13,15,18,21-22H,1,7-10H2/t12-,13+,15-,18-,19-/m0/s1
- IUPAC Name
- (1S,5R,13R,14S,17R)-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,15-tetraene-10,14-diol
- SMILES
- [H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC=C)[C@]([H])(C4)[C@]1([H])C=C[C@@H]2O
References
- General References
- Not Available
- External Links
- KEGG Drug
- D08247
- KEGG Compound
- C11787
- ChemSpider
- 4447643
- BindingDB
- 50367061
- ChEBI
- 7458
- ChEMBL
- CHEMBL415284
- ZINC
- ZINC000003875420
- Wikipedia
- Nalorphine
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 1.36 mg/mL ALOGPS logP 1.55 ALOGPS logP 1.68 Chemaxon logS -2.4 ALOGPS pKa (Strongest Acidic) 10.2 Chemaxon pKa (Strongest Basic) 8.81 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 52.93 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 89.29 m3·mol-1 Chemaxon Polarizability 33.3 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS splash10-0006-7090000000-c2f0177beb4226c08a1f Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-03di-0039000000-be4a68c14c6729275b79 Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-03di-0009000000-5bb15eaaa9dc974d5120 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-03di-0079000000-a3d425b3bb646b873a38 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-03di-0009000000-733d801636b215c32d22 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0btc-0091000000-1917079f3b7f509e9c7c Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-03di-0094000000-8595600b1f0e1cd3b73d Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 180.0712884 predictedDarkChem Lite v0.1.0 [M-H]- 177.55617 predictedDeepCCS 1.0 (2019) [M+H]+ 179.5927884 predictedDarkChem Lite v0.1.0 [M+H]+ 179.95174 predictedDeepCCS 1.0 (2019) [M+Na]+ 179.7872884 predictedDarkChem Lite v0.1.0 [M+Na]+ 187.21869 predictedDeepCCS 1.0 (2019)
Drug created at February 26, 2016 00:04 / Updated at July 28, 2023 21:40