Nalorphine

DB11490ExperimentalVet approvedSmall molecule

Nalorphine is a mixed opioid agonist–antagonist. It acts at two opioid receptors—at the mu receptor it has antagonistic effects, and at the kappa receptors it exerts high-efficacy agonistic characteristics. It... It is used to reverse opioid overdose and (starting in the 1950s) in a challenge test to determine opioid dependence.

Chemical structure of Nalorphine
Primary indication
Used to reverse opioid overdose.Curator reviewed
Formula / weight
C19H21NO3 · 311.381 g/mol (avg)

Resolves to

Compound
UNIIU59WB2WRY2CAS62-67-9ChEMBLCHEMBL415284ChEBI7458KEGGD08247
Clinical / RWD
ATCV03AB02
Structure
InChIKeyUIQMVEYFGZJHCZ-SSTWWWIQSA-NSMILES[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC=C)[C@]([H])(C4)[C@]1([H])C=C[C@@H]2O
Targets
P41145OPRK1

What you can answer from here — as of September 11, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
54Drug interactionsStructured to mechanism, not free text
Sign in
1ATC codeIncluding every combination product, plus 13 drug categories
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which drugs share a target with Nalorphine, and which of those have an active Phase 3 trial?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In