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Displaying results 4671 - 4680 of 10000 in total
  1. Drug

    Hydrochlorothiazide

    go.drugbank.com/drugs/DB00999
    ApprovedInvestigationalVet approved

    [L7426,L7459] Hydrochlorothiazide was granted FDA approval on 12 February 1959.[L8444] … [A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.

    Mixtures: OLMESAR/HCT AL 40/25 MG, OLMESAR/HCT AL 40/25 MGCategories: Heterocyclic Compounds, 2-Ring
  2. Drug

    Trospium

    go.drugbank.com/drugs/DB00209
    ApprovedInvestigational

    Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. … [L6208] An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination.

    Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsProducts: TROSBIO® 30 MG, TROSBIO® 15 MG
  3. Drug

    Durvalumab

    go.drugbank.com/drugs/DB11714
    ApprovedInvestigational

    Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. … [A192789,L12627] On March 27, 2020, durvalumab was approved by the FDA for use in combination with [etoposide] and either [carboplatin] or [cisplatin] as first-line treatment of patients with extensive-stage

    Categories: PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors, PD-1/PD-L1 (Programmed cell death protein 1/death ligand 1) inhibitorsProducts: IMFINZI® 50 MG/ML CONCENTRADO PARA SOLUCIÓN PARA INFUSIÓN, IMFINZI 120 MG/2.4 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET
  4. Drug

    Nalbuphine

    go.drugbank.com/drugs/DB00844
    ApprovedInvestigational

    A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. … Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States.

    Categories: Heterocyclic Compounds with 4 or More RingsSynonyms: N-cyclobutylmethyl-4,5α-epoxy-3,6α,14-morphinantriol
  5. Drug

    Dolutegravir

    go.drugbank.com/drugs/DB08930
    ApprovedInvestigational

    Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI). … [L1035] On November 21, 2017, dolutegravir, in combination with rilpivirine, was approved as part of the first complete treatment regimen with only two drugs for the treatment of adults with HIV-1 named

    Mixtures: TRIUMEQ® 50 MG / 600 MG / 300 MG, TRIUMEQ 50 MG/600 MG/300 MG FILM KAPLI TABLET,90 FILM KAPLI TABLETCategories: MATE 1 Inhibitors, P-glycoprotein substrates
  6. Drug

    Mineral oil

    go.drugbank.com/drugs/DB11057
    ApprovedInvestigationalVet approved

    Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. … Mineral oil is a common ingredient in baby lotions, cold creams, ointments and cosmetics to treat and prevent dry, rough, scaly, itchy skin and minor skin irritations.

    Mixtures: AGAROL CON SABOR A FRAMBUESA, AGAROL M (EMULSION)Products: LIQUID PARAFFIN EMULSION 2.5 ml/5 ml, Gelee Laxative A LA Framboise
  7. Drug

    Iron protein succinylate

    go.drugbank.com/drugs/DB11209
    Approved

    Mixtures: FERPLEX FOL 40 MG + 0.185 MG/15 ML ORAL ÇÖZELTİ, 10 ADET, KOMFER FOL 40 MG/185 MCG ORAL COZELTI, 10 FLK.Products: KOMFER 40 MG ORAL ÇÖZELTİ, 15 ML X 10 FLAKON, KOMFER 40 MG ORAL ÇÖZELTİ, 15 ML X 20 FLAKON
  8. Drug

    Memantine

    go.drugbank.com/drugs/DB01043
    ApprovedInvestigational

    In December 2013, the G8 dementia summit concluded that dementia should be considered a global priority with the objective of developing a cure or a disease-modifying therapy by the year 2025 [L5953, F4366 … Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD).

    Mixtures: EBICOMB 5 MG/5 MG EFERVESAN TABLET, 28 ADET, DONEPTIN 5 MG/5 MG FILM KAPLI TABLET, 28 ADETCategories: N-methyl-D-aspartate Receptor Antagonist, Cytochrome P-450 CYP2A6 Inhibitors
  9. Drug

    Gabapentin

    go.drugbank.com/drugs/DB00996
    ApprovedInvestigational

    Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993. … [A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism

    Mixtures: GAVINDO N, Innoprax-5Synonyms: 1-(Aminomethyl)cyclohexaneacetic acid
  10. Drug

    Milrinone

    go.drugbank.com/drugs/DB00235
    ApprovedInvestigational

    Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. … [A228333] As a PDE-III inhibitor, milrinone results in increased cAMP levels and improves cardiac function and peripheral vasodilation in acute decongested heart failure.

    Mixtures: Milrinone Lactate in DextroseCategories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-Ring