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Mepolizumab
go.drugbank.com/drugs/DB06612ApprovedInvestigationalEosinophils are involved in inflammatory immune responses, and prolonged hypereosinophilia (typically defined as absolute eosinophil levels of 1500/mm<sup>3</sup> or more) is associated with a spectrum … Mepolizumab was first approved by the FDA on November 4, 2015, as an add-on therapy for severe asthma and marketed under the brand name Nucala by GlaxoSmithKline.
Categories: Interleukin-5 AntagonistProducts: Nucala 40 mg/0,4 mL S.C. Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör (1 adet), Nucala 40 mg/0,4 mL S.C. Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Enjektör (3 adet)Amphotericin B
go.drugbank.com/drugs/DB00681ApprovedInvestigationalAmphotericin B shows a high order of in vitro activity against many species of fungi. … ranging from 0.03 to 1.0 mcg/mL in vitro.
Synonyms: AMPH-b, Amfotericina BSalts: Amphotericin B Cholesteryl Sulfate ComplexEscitalopram
go.drugbank.com/drugs/DB01175ApprovedInvestigationalEscitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. … that the R-enantiomer of racemic citalopram actively dampens the activity of escitalopram rather than existing simply as an inactive enantiomer.
Categories: Monoamine Oxidase A Substrates, P-glycoprotein substratesSynonyms: (S)-Citalopram, S(+)-CitalopramPropafenone
go.drugbank.com/drugs/DB01182ApprovedInvestigationalAn antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Categories: Antiarrhythmics, Class I, P-glycoprotein inhibitorsSynonyms: 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone, 2-(2'-hydroxy-3'-propylaminopropoxy)-ω-phenylpropiophenoneFluvoxamine
go.drugbank.com/drugs/DB00176ApprovedInvestigationalFluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. … Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database comprised of approximately 35,000 patients.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: VERLIN TABLETAS X 50 MG, VOXAMIN® TABLETA RECUBIERTAMethadone
go.drugbank.com/drugs/DB00333ApprovedInvestigationalMethadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. … (due to a lack of active metabolites), minimal accumulation in renal failure, good bioavailability, low cost, and a long duration of action.
Categories: Drugs Used in Opioid Dependence, Drugs Used in Addictive DisordersSynonyms: 6-Dimethylamino-4,4-diphenyl-3-heptanoneSibutramine
go.drugbank.com/drugs/DB01105ApprovedIllicitWithdrawnIt is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled substance in the United States. … In October 2010, Sibutramine was withdrawn from Canadian and U.S. markets due to concerns that the drug increases the risk of heart attack and stroke in patients with a history of heart disease.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: OBESTOP® 10 MG CAPSULAS, OBESTOPPOR 5 MG CAPSULASRamipril
go.drugbank.com/drugs/DB00178ApprovedInvestigationalRamipril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to ramiprilat in the liver and, to a lesser extent, kidneys. … Ramiprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).
Mixtures: Lasitace 5 mg/40 mg Kapseln, Trinomia 100 mg/40 mg/5 mg HartkapselnCategories: Heterocyclic Compounds, 2-Ring, Agents Acting on the Renin-Angiotensin SystemDexchlorpheniramine maleate
go.drugbank.com/drugs/DB09555ApprovedDexchlorpheniramine is the S-enantiomer of chlorpheniramine which is a 1st generation anti-histamine. … Dexchlorpheniramine has more pharmacological activity than the R and so is more potent than the racemic mixture.
Mixtures: HUFADEXTA-M, INTUNAL-FCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsVinorelbine
go.drugbank.com/drugs/DB00361ApprovedInvestigationalIt was initially approved in the USA in 1990's for the treatment of NSCLC [L2010]. It is a third-generation vinca alkaloid. … A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations.
Synonyms: 5'-NoranhydrovinblastineCategories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 Substrates