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Displaying results 4751 - 4760 of 10000 in total
  1. Indication

    Mucopolysaccharidosis Type IVA

    go.drugbank.com/conditions/DBCOND0060256
    Drugs: Elosulfase alfa
    Synonyms: MPS IV-A-Mucopolysaccharidosis IV-A, Morquio A Disease
  2. Target

    Gamma-aminobutyric acid receptor subunit alpha-4

    go.drugbank.com/bio_entities/BE0000478
    TargetHumans

    GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit … Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (By similarity).

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-4Synonyms: GABA(A) receptor subunit alpha-4, GABAAR subunit alpha-4
  3. Target

    C-X-C chemokine receptor type 4

    go.drugbank.com/bio_entities/BE0000919
    TargetHumans

    Plays a role in regulation of cell migration, e.g. during wound healing (PubMed:28978524). … Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels (PubMed:20228059).

    Polypeptides: C-X-C chemokine receptor type 4Synonyms: CXCR-4
  4. Target

    2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

    go.drugbank.com/bio_entities/BE0001488
    TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

    Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.

    Polypeptides: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseFunction: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
  5. Target

    3-oxo-5-alpha-steroid 4-dehydrogenase

    go.drugbank.com/bio_entities/BE0004887
    EnzymeTargetHumans

    Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed … Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism (PubMed:38821050).

    Polypeptides: 3-oxo-5-alpha-steroid 4-dehydrogenase 1, 3-oxo-5-alpha-steroid 4-dehydrogenase 2Synonyms: 3-oxo-5-alpha-steroid 4-dehydrogenase 3
  6. Target

    Receptor-interacting serine/threonine-protein kinase 4

    go.drugbank.com/bio_entities/BE0009533
    TargetHumans

    It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564)

    Polypeptides: Receptor-interacting serine/threonine-protein kinase 4
  7. Target

    Tumor necrosis factor receptor superfamily member 4

    go.drugbank.com/bio_entities/BE0010535
    TargetHumans

    Is a costimulatory molecule implicated in long-term T-cell immunity

    Polypeptides: Tumor necrosis factor receptor superfamily member 4
  8. Target

    Tumor necrosis factor ligand superfamily member 4

    go.drugbank.com/bio_entities/BE0010661
    TargetHumans

    Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production

    Polypeptides: Tumor necrosis factor ligand superfamily member 4
  9. Target

    Dual specificity tyrosine-phosphorylation-regulated kinase 4

    go.drugbank.com/bio_entities/BE0020146
    TargetHumans

    Possible non-essential role in spermiogenesis

    Polypeptides: Dual specificity tyrosine-phosphorylation-regulated kinase 4
  10. Drug

    Ferric cation

    go.drugbank.com/drugs/DB13949
    ApprovedWithdrawn

    Iron is a transition metal with a symbol Fe and atomic number 26. By mass, it is the most common element on Earth. … Ferric citrate (tetraferric tricitrate decahydrate) is a phosphate binder indicated for the control of serum phosphorus levels in patients with chronic kidney disease on dialysis.

    Synonyms: iron(3+)Mixtures: MALTOFER FOL 100 MG/0.35 MG TABLET, 30 ADET