C-X-C chemokine receptor type 4

BE0000919ProteinHumansCXCR4

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10074102, PubMed:10452968, PubMed:10644702, PubMed:10825158, PubMed:18799424, PubMed:20048153, PubMed:20505072, PubMed:24912431, PubMed:28978524, PubMed:8752280, PubMed:8752281). It is acted on by 20 drugs in DrugBank.

Gene name
CXCR4
UniProtKB entry
P61073Swiss-Prot
Cellular location
Cell membrane
Residues / weight
352 residues · 39,745 Da
Also known as
CXC-R4 · CXCR-4 · FB22 · Fusin · HM89

Resolves to

Protein
UniProtP61073UniProt nameCXCR4_HUMAN
Gene
HGNCHGNC:2561NCBI Gene7852GenBank189314GeneCardsCXCR4
Pharmacology
IUPHAR/GtoPdb71KEGGhsa:7852
Structure
PDB22XCPDB2K03PDB2K04
Drugs

What you can answer from here — as of September 07, 2019

20DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
39Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
19GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
110+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on C-X-C chemokine receptor type 4, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In