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AME-527
go.drugbank.com/drugs/DB05879ExperimentalAME-527 was generated by protein engineering and identified from a library of antibody variants based on its improved binding properties. … AME-527 is a humanized monoclonal antibody that recognizes human TNF-alpha (hTNF-alpha) with high affinity and specificity.
XL999
go.drugbank.com/drugs/DB05014InvestigationalXL999 induces a cell-cycle block by a mechanism distinct from those previously identified and exhibits broad antitumor activity in xenograft models. … XL999 has the potential to prevent tumor growth — both directly by a novel effect on tumor cell proliferation and indirectly through inhibition of the host angiogenic response.
Nisoxetine
go.drugbank.com/drugs/DB09186ExperimentalIt was originally investigated as an antidepressant but has no current clinical applications aside from being a research standard SNRI. … It has been used to research obesity and energy balance, and exerts some local analgesia effects.
Olokizumab
go.drugbank.com/drugs/DB13127InvestigationalInterleukin-6 (IL-6) is an important cytokine with roles in immune cell proliferation/differentiation, energy and bone metabolism, and the acute phase response of the innate immune system. … IL-6 pathway dysregulation is associated with chronic inflammation and lymphoproliferation, including in autoimmune conditions such as rheumatoid arthritis, Castleman disease, and cytokine release syndrome
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsRipasudil
go.drugbank.com/drugs/DB13165InvestigationalRipasudil, as hydrochloride hydrate (K-115), is a specifc Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor used for the treatment of glaucoma and ocular hypertension. … This medication is available in the form of a 0.4% eye drop solution under the brand name Glanatec.
Categories: brimonidine and ripasudil, Antiglaucoma Preparations and MioticsOxiconazole
go.drugbank.com/drugs/DB00239ApprovedIt is marketed under the brand names Oxistat and Oxistat, and is used in the treatment of various skin infections such as athlete's foot, jock itch and ringworm. … Oxiconazole is an antifungal agent that is commonly found in topical formulations.
Categories: Imidazole and Triazole Derivatives, Genito Urinary System and Sex HormonesSpirapril
go.drugbank.com/drugs/DB01348ApprovedInvestigationalACE inhibitors are used primarily in treatment of hypertension and congestive heart failure. … Spirapril is an ACE inhibitor antihypertensive drug used to treat hypertension. Spirapril is converted to the active spiraprilat after administration.
Categories: Amino Acids, Peptides, and ProteinsD-threo-neopterin
go.drugbank.com/drugs/DB02385ExperimentalA pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. … (From Stedman, 26th ed) Neopterin also serves as a precursor in the biosynthesis of biopterin.
Categories: Enzymes and CoenzymesSynonyms: Neopterin D-threo-formAprocitentan
go.drugbank.com/drugs/DB15059ApprovedInvestigational[A263386] Patients with resistant hypertension are at an increased risk of cardiovascular and renal events[A263386] and have traditionally had limited additional treatment options. … [A263386,L50261] Aprocitentan was approved by the FDA in March 2024 for the treatment of hypertension in patients inadequately controlled with standard therapy.
Epratuzumab
go.drugbank.com/drugs/DB04958InvestigationalEpratuzumab is a humanized monoclonal antibody derived from the murine IG2a monoclonal antibody, LL2 (EPB-2). … This agent may subsequently be well matched for use in oncology and the treatment of inflammatory autoimmune disorders, such as lupus.
Categories: Amino Acids, Peptides, and Proteins