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Previously treated with an HCV regimen containing sofosbuvir without an NS5A inhibitor Chronic hepatitis C genotype 3
go.drugbank.com/conditions/DBCOND0093782Drugs: VoxilaprevirSynonyms: Previously treated with an HCV regimen containing sofosbuvir without an NS5A inhibitor Chronic hepatitis C genotype 3Geneticin
go.drugbank.com/drugs/DB04263ExperimentalResistance to Geneticin is conferred by the neo gene from Tn5 encoding an aminoglycoside 3‘-phosphotransferase, APH 3‘ II. … Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells and is commonly used in laboratory research to select genetically engineered cells.
Lapyrium
go.drugbank.com/drugs/DB09376ApprovedLapyrium is a quaternary ammonium cation used as a surfactant, antistatic agent, and biocide in various cosmetic products [A19426]. It is commonly found formulated as lapyrium chloride.
Filgotinib
go.drugbank.com/drugs/DB14845ApprovedInvestigationalRheumatoid arthritis (RA) is a chronic, autoimmune, systemic, and inflammatory disease that causes synovial joint symptoms and can limit range of motion in severe cases. … [A221451,A221456] The disease is associated with extra-articular manifestations, progressive disability, and comorbidities including cardiovascular disease and mental disorders.
Categories: Antineoplastic and Immunomodulating AgentsRomlusevimab
go.drugbank.com/drugs/DB16494InvestigationalRomlusevimab (BRII-198) was under investigation in clinical trials (NCT04479644 and NCT04691180) to treat COVID-19, focusing on its safety, tolerability, and pharmacokinetics.
Categories: Amino Acids, Peptides, and ProteinsNirogacestat
go.drugbank.com/drugs/DB12005ApprovedInvestigationaland thus impede the growth of desmoid tumors. … [A262556] Interaction between the notch receptors and their ligands activates proteolytic cleavage by gamma-secretase; therefore, the inhibition of gamma-secretase can potentially inhibit Notch signaling
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsRoxatidine acetate
go.drugbank.com/drugs/DB08806InvestigationalRoxatidine acetate is a specific and competitive H2 receptor antagonist. It is currently approved in South Africa under the tradename Roxit.
Categories: Alimentary Tract and Metabolism, Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord)Ifenprodil
go.drugbank.com/drugs/DB08954ApprovedInvestigationalWithdrawnIn addition, allosteric modulators are known to bind at the NTDs and form another layer of regulation. … [A220143, A196128] In an unbiased screen for compounds capable of reducing cell death induced by infection with the influenza strain H5N1, ifenprodil was found to have a protective effect against H5N1-
Dabigatran
go.drugbank.com/drugs/DB14726ApprovedInvestigationalDabigatran is the active form of the orally bioavailable prodrug [dabigatran etexilate].
Nadofaragene firadenovec
go.drugbank.com/drugs/DB17381ApprovedInvestigationalIt is the first gene therapy approved by the FDA for the treatment of bladder cancer.[L44381,L44431] BCG-unresponsive NMIBC has a high recurrence and is notably difficult to treat. … [A255111] Nadofaragene firadenovec is formulated with an excipient (Syn-3) that facilitates gene transfer across the urothelium and promotes the transduction of IFNα2b.
Categories: Cellular and Gene Therapy, Antineoplastic cell and gene therapy