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Olmesartan
go.drugbank.com/drugs/DB00275ApprovedInvestigational[A174124,A178153,A173869,A185324,A185327,A185333,A185342,A185345] Like other ARBs, olmesartan blockade of RAAS slows the progression of diabetic nephropathy due to its renoprotective effects. … ARBs such as olmesartan have been shown in a number of large-scale clinical outcomes trials to improve cardiovascular outcomes including reducing risk of myocardial infarction, stroke, the progression
Mixtures: OLMEDIPIN® AM 20/10, NORSAT-DUOProducts: OLMESARTAN AL 10 MG FTA, OLMESARTAN AL 20 MG FTANalbuphine
go.drugbank.com/drugs/DB00844ApprovedInvestigationalA narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. … Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States.
Products: Nubain 10 mg/ml Injektionslösung, NALBUFINA CLORHIDRATO 10 MG/ML.Clobazam
go.drugbank.com/drugs/DB00349ApprovedIllicitInvestigational[A256968,A256973] Clobazam has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. … [A256958] In 2005, clobazam also received approval from Health Canada as an add-on therapy for generalized tonic-clonic, myoclonic, and focal impaired awareness seizures.[A256978]
Categories: GABA-A Receptor Agonists, Cytochrome P-450 SubstratesProducts: FRISIUM 10 TABLET 10 mg, Frisium 10 mg TablettenHomosalate
go.drugbank.com/drugs/DB11064ApprovedHomosalate is an organic compound that belongs to salicylates. It is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol. … It is a common ingredient in many commercially available sunscreens. There are no reported adverse effects from homosalate.
Mixtures: Nu Skin ageLOC Me, L OCCITANE AU BRESIL - JENIPAPO Lip Gloss SPF 25 Broad SpectrumCategories: Compounds used in a research, industrial, or household settingBuspirone
go.drugbank.com/drugs/DB00490ApprovedInvestigationalBuspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. … Due to these characteristics, buspirone been termed 'anxioselective'.[A180985] First synthesized in 1968 then patented in 1975,[L7375] it is commonly marketed under the brand name Buspar®.
Categories: Dopamine D2 Receptor Antagonists, Cytochrome P-450 SubstratesProducts: NOPIRON 10 MG TABLET, 100 ADET, BUSPON 10 MG KAPSÜL, 50 KAPSÜLAmitriptyline
go.drugbank.com/drugs/DB00321ApprovedInvestigationalAmitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961.
Synonyms: 10,11-dihydro-5-(γ-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene, 10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Δ5,γ-propylamineMixtures: Etrafon A Tab, Apo Peram Tab 3-15Durvalumab
go.drugbank.com/drugs/DB11714ApprovedInvestigationalDurvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. … [L12624] It is additionally approved in Canada under the same name (Imfinzi) for similar indications, as well as the treatment of patients with locally advanced or metastatic urothelial carcinoma.
Products: IMFINZI CONCENTRATE FOR SOLUTION FOR INFUSION 50 MG/ML, IMFINZI 120 MG/2.4 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADETOxcarbazepine
go.drugbank.com/drugs/DB00776ApprovedInvestigational[L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood … - a pro-drug of the more active (S)-enantiomer is also marketed as a separate anti-epileptic under the name [eslicarbazepine].
Synonyms: 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamideCategories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersMinoxidil
go.drugbank.com/drugs/DB00350ApprovedInvestigationalA potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.
Products: Alopexy 50 mg/ml Lösung zur Anwendung auf der Haut, Minoxipel 50 mg/ml Lösung zur Anwendung auf der HautAzathioprine
go.drugbank.com/drugs/DB00993ApprovedInvestigationalAzathioprine is a prodrug of 6-mercaptopurine, first synthesized in 1956 by Gertrude Elion, William Lange, and George Hitchings in an attempt to produce a derivative of 6-mercaptopurine with a better therapeutic … [A189678,A189687,A189690] Azathioprine is used to treat inflammatory conditions like rheumatoid arthritis and as an immunosuppressant in the prevention of renal transplant rejection.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: Nu-azathioprine, IMURAN 50 MG TABLET, 100 ADET