Homosalate

DB11064ApprovedSmall molecule

Homosalate is an organic compound that belongs to salicylates. It is an ester formed from salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol. Salicylates prevent direct skin exposure to the... Homosalate specifically absorbs short-wave UVB rays, which are associated with DNA damage and increased risk of skin cancer.

Chemical structure of Homosalate
Mechanism
Curator reviewed
Primary indication
As ingredient in many sunscreen for protection against sunburn, skin aging and skin cancer.Curator reviewed · 1 structured indication
Formula / weight
C16H22O3 · 262.349 g/mol (avg)
First approval
Canada, 1997
Code names
Caswell No. 482B
Brand names
  • Meijer

Resolves to

Compound
UNIIV06SV4M95SCAS118-56-9ChEMBLCHEMBL1377575ChEBI91642
Clinical / RWD
RxNorm91326
Structure
InChIKeyWSSJONWNBBTCMG-UHFFFAOYSA-NSMILESCC1CC(CC(C)(C)C1)OC(=O)C1=C(O)C=CC=C1
Targets
P06401PGRP10275ARP03372ESR1

What you can answer from here — as of March 06, 2025

3Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
5Clinical trialsPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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6,586Marketed productsAcross 2 countries and 752 labellers
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6+ReferencesStructured and connected to the statements they support
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