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Pemivibart
go.drugbank.com/drugs/DB18720Investigational[L51733] Due to the amino acid substitutions in the Fc region (M435L/N441A), pemivibart has an extended serum half-life.[L51728] … [L50326] It received emergency use authorization (EUA) from the FDA in March 2024 for pre-exposure prophylaxis (PrEP) of COVID-19 in certain high-risk patient populations.
Categories: Amino Acids, Peptides, and ProteinsMepenzolate
go.drugbank.com/drugs/DB04843ApprovedWithdrawnMepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. … Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ganglionic parasympathetic inhibitor.
Categories: Alimentary Tract and MetabolismAfimetoran
go.drugbank.com/drugs/DB16580InvestigationalAfimetoran is an immunomodulator and an antagonist of toll-like receptors 7 and 8. … [L32018, L32023] It is also is under investigation in clinical trial NCT04269356 (Study to Assess the Way the Body Absorbs, Distributes, Breaks Down and Eliminates Radioactive BMS-986256 in Healthy Male
Androstenedione
go.drugbank.com/drugs/DB01536IllicitInvestigationalA delta-4 C19 steroid that is produced not only in the testis, but also in the ovary and the adrenal cortex. … Depending on the tissue type, androstenedione can serve as a precursor to testosterone as well as estrone and estradiol.
Categories: Hormones, Hormone Substitutes, and Hormone AntagonistsBisegliptin
go.drugbank.com/drugs/DB06127InvestigationalIt is an orally active, dipeptidyl peptidase-IV (DPPIV) inhibitor which lowers blood glucose levels by blocking the degradation of the hormone GLP-1 thereby stimulating glucose-dependent insulin secretion … and lowering blood glucose levels without hypoglycemic effects.
Categories: DPP-IV InhibitorsNitrofural
go.drugbank.com/drugs/DB00336ApprovedVet approvedWithdrawnNitrofural or nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. … Nitrofural has also been administered orally in the treatment of trypanosomiasis.
Categories: Antiseptics and Disinfectants, Blood and Blood Forming OrgansACA 125
go.drugbank.com/drugs/DB05489InvestigationalACA-125 mimics the tumor-associated antigen CA-125, which can be detected in about 80% of ovarian carcinomas. … An IgG1 murine monoclonal anti-idiotype antibody (Ab2), ACA-125, was developed to bind to anti-CA 125 antibodies.
Topiroxostat
go.drugbank.com/drugs/DB01685InvestigationalTopiroxostat and its metabolites are shown to be unaffected by renal complications, thus may be effective in patients with chronic kidney diseases [A19657]. … Approved for therapeutic use in Japan since 2013, topiroxostat is marketed under the name Topiloric and Uriadec and is orally administered twice daily.
Gedatolisib
go.drugbank.com/drugs/DB11896ApprovedInvestigational[L63927] Gedatolisib was approved by the FDA on July 14, 2026, in combination with [fulvestrant], with or without [palbociclib], for adults with HR-positive, HER2-negative locally advanced or metastatic … Gedatolisib is a kinase inhibitor that blocks all four class I PI3K isoforms together with both mTOR complexes, mTORC1 and mTORC2, producing downstream inhibition of multiple effectors including AKT.
Categories: Antineoplastic and Immunomodulating Agents, Class I Phosphatidylinositol 3-Kinases, antagonists & inhibitorsGoserelin
go.drugbank.com/drugs/DB00014ApprovedInvestigationalGoserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. … In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state.
Categories: Hormones and Related Agents, Amino Acids, Peptides, and Proteins