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Displaying results 4981 - 4990 of 10000 in total
  1. Drug

    TM5614

    go.drugbank.com/drugs/DB16516
    Investigational

    Further investigation of this compound is underway, including an exploratry Phase II study for its efficacy and safety for high-risk hospitalized patients with severe COVID-19 pneumonia[L31688]. … An animal study in mice fed a fast-food diet with TM5614 treatment showed improved metabolic measurements and reduced liver steatosis[L31673,L31678].

    Categories: Experimental Unapproved Treatments for COVID-19
  2. Pathway

    Autophagy

    smpdb.ca/view/SMP0578913
    Signaling

    kinase 2 (CAMKK2) directly phosphorylates and activates AMPK, which in turn phosphorylates ULK1 to trigger phagophore formation in an mTOR‑independent manner. … autolysosomes in which sequestered cargo is degraded and recycled.

    Drugs: Adenosine phosphate · Calcium
    Enzymes: Activating molecule in BECN1-regulated autophagy protein 1
  3. Drug

    MK-3577

    go.drugbank.com/drugs/DB14957
    Investigational

    MK-3577 is under investigation in clinical trial NCT00868790 (A Study of the Safety and Efficacy of MK-3577 in Participants With Type 2 Diabetes Mellitus (MK-3577-009)).

  4. Drug

    Glisoxepide

    go.drugbank.com/drugs/DB01289
    Investigational

    However it inhibits taurocholate uptake only in the absence of sodium ions. … These results are consistent with the transport of glisoxepide via the transport system for the unconjugated bile acid cholate. [A31819,A31820]

    Categories: Drugs Used in Diabetes
  5. Drug

    HMR4011

    go.drugbank.com/drugs/DB06225
    Experimental

    IPL 576,092 has previously been investigated as a treatment for asthma. … HMR4011 (IPL 576,092) is a novel steroidal anti-inflammatory compound with a mechanism of action distinct from that of glucocorticoid.

  6. Drug

    LS11

    go.drugbank.com/drugs/DB05918
    Investigational

    It is used to treat many kinds of cancers. … After intratumoral activation by light emitting diodes, taporfin sodium forms an extended high energy conformational state that generates singlet oxygen, resulting in free radical-mediated cell death.

  7. Drug

    MAS825

    go.drugbank.com/drugs/DB16452
    Investigational

    Categories: Experimental Unapproved Treatments for COVID-19
  8. Drug

    Deramciclane

    go.drugbank.com/drugs/DB06512
    Investigational

    Deramciclane (EGIS-3886) is used for the treatment of a number of anxiety disorders. … Deramciclane differs from other anti anxiety medications in that it is not a benzodiazepine and so has a different structure and target.

  9. Drug

    PSN9301

    go.drugbank.com/drugs/DB05001
    Experimental

    PSN9301 is an oral small molecule inhibitor of Dipeptidyl Peptidase IV (DP-IV), being developed for the treatment of type 2 diabetes. … PSN9301 has a very rapid onset and a relatively short duration of action, and available pre-clinical and clinical data indicate that it may be an ideal product candidate for meal-related dosing.

  10. Drug

    Fusafungine

    go.drugbank.com/drugs/DB08965
    ApprovedWithdrawn

    Fusafungine is an antibiotic from Fusarium lateririum, and is used for the treatment of respiratory infections.