Search
Methotrexate
go.drugbank.com/drugs/DB00563ApprovedInvestigationalMethotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. … [A180322,L7144,L7147,L7150,L7180] Due to the toxic effects of methotrexate, it is indicated for treatment of some forms of arthritis and severe psoriasis only if first line treatment has failed or patients
Categories: OAT3/SLC22A8 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: 4-amino-10-methylfolic acid, 4-amino-N(10)-methylpteroylglutamic acidPerphenazine
go.drugbank.com/drugs/DB00850ApprovedInvestigationalAn antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.
Mixtures: โพลีบอน 4-10, Etrafon 2 10Synonyms: 2-(4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol, 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol10-decarboxymethylaclacinomycin A
go.drugbank.com/drugs/DB01806ExperimentalSynonyms: 10-decarboxymethylaclacinomycin AADL 10-0101
go.drugbank.com/drugs/DB05443ExperimentalADL 10-0101 is a peripheral kappa opioid agonist analgesic product candidate. … Preclinical trials of ADL 10-0101 have suggested that the compound may be effective for the treatment of inflammatory pain, itch and visceral pain.
Mesoridazine
go.drugbank.com/drugs/DB00933ApprovedWithdrawnA phenothiazine antipsychotic with effects similar to chlorpromazine.
Synonyms: 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylsulfinyl phenothiazine, 2-Methanesulfinyl-10-[2-(1-methyl-piperidin-2-yl)-ethyl]-10H-phenothiazineThioridazine
go.drugbank.com/drugs/DB00679ApprovedWithdrawnA phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. … Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618).
Categories: Adrenergic alpha-1 Receptor AntagonistsSynonyms: 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazine, 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazinePromazine
go.drugbank.com/drugs/DB00420ApprovedVet approvedWithdrawnIt is currently not approved for use in the United States. … A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
Categories: Adrenergic alpha-1 Receptor AntagonistsSynonyms: N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine, 10-(3-(Dimethylamino)propyl)phenothiazineEstriol
go.drugbank.com/drugs/DB04573ApprovedInvestigationalVet approvedA hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. … It has also been approved and marketed throughout Europe and Asia for approximately 40 years for the treatment of post-menopausal hot flashes.
Mixtures: GYNOFLOR 50 MG/0.03 MG VAJİNAL TABLET, 12 ADET, GYNOFLOR 50 MG/0.03 MG VAJİNAL TABLET, 6 ADETSynonyms: (16α,17β)-estra-1,3,5(10)-triene-3,16,17-triol, 1,3,5(10)-Estratriene-3,16-alpha,17beta-triolEstradiol
go.drugbank.com/drugs/DB00783ApprovedInvestigationalVet approved[L11485,L11488,L11491, L11494,L11497,L11500,L11503] When used for oral or IM administration, estradiol is commonly synthesized as a pro-drug ester (such as [DB13952], [DB13953], [DB13954], [DB13955 … Estradiol is a naturally occurring hormone circulating endogenously in females.
Synonyms: (17β)-estra-1,3,5(10)-triene-3,17-diol, 17β-estra-1,3,5(10)-triene-3,17-diolInternational brands: Estraderm MX(R)-tacrine(10)-hupyridone
go.drugbank.com/drugs/DB04614ExperimentalSynonyms: (R)-tacrine(10)-hupyridone