Search

Displaying results 41 - 50 of 91 in total
  1. Drug

    rAAV1-CB-hAAT

    go.drugbank.com/drugs/DB18724
    Investigational

    rAAV1-CB-hAAT is a recombinant adeno-associated virus alpha 1-antitrypsin vector.

    Synonyms: recombinant adeno-associated virus alpha 1-antitrypsin vectorCategories: Adeno-associated Viral Vector Therapies
  2. Drug

    Resamirigene bilparvovec

    go.drugbank.com/drugs/DB16779
    Investigational

    AT132 is under investigation in clinical trial NCT03199469 (Gene Transfer Clinical Study in X-linked Myotubular Myopathy).

    Synonyms: DNA (synthetic adeno-associated virus 8 vector AT132 human myotubularin cDNA-specifying), Non-replicating adeno-associated viral vector, serotype 8, expressing human myotubularin geneCategories: Adeno-associated Viral Vector Therapies
  3. Drug

    RGX-111

    go.drugbank.com/drugs/DB17632
    Investigational

    RGX-111 is an adeno-associated virus vector AAV9 designed to deliver the α-L-iduronidase (IDUA) gene.

    Synonyms: Adeno-associated virus vector serotype 9 expressing human a-L-iduronidase
  4. Drug

    AGTC-402

    go.drugbank.com/drugs/DB18433
    Investigational

    AGTC-402 is a recombinant adeno-associated virus vector expressing the cyclic nucleotide gated channel alpha subunit (CNGA3).

    Synonyms: recombinant Adeno-associated virus vector expressing CNGA3
  5. Drug

    Leuvectin

    go.drugbank.com/drugs/DB17303
    Investigational

    Leuvectin (formerly known as VCL-1102) is a component of gene therapy along with cationic lipid 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide/dioleyl-phosphatidyl-ethanolamine (DMRIE/DOPE).

    Synonyms: DNA-lipid complex (DMRIE/DOPE)/plasmid vector (VCL-1102, Vical) expressing human interleukin-2
  6. Drug

    Afamitresgene autoleucel

    go.drugbank.com/drugs/DB18592
    ApprovedInvestigational

    melanoma-associated antigen A4 (MAGE-A4)-directed genetically modified autologous T cell immunotherapy product consisting of CD4 and CD8 positive T cells transduced with a self-inactivating lentiviral vector

    Synonyms: AUTOLOGOUS CD4+ AND CD8+ T CELLS OBTAINED BY LEUKAPHERESIS, TRANSDUCED WITH AN HIV-DERIVED SELF-INACTIVATING (SIN) LENTIVIRAL VECTOR, ENCODING AN ENHANCED-AFFINITY T CELL RECEPTOR (TCR) SPECIFIC FOR THE
  7. Drug

    AMT-130

    go.drugbank.com/drugs/DB16975
    Investigational

    Synonyms: Adeno-associated viral vector serotype 5 encoding a microRNA targeted to human Huntingtin gene
  8. Drug

    Zopapogene imadenovec

    go.drugbank.com/drugs/DB24672
    ApprovedInvestigational

    [L54081] Zopapogene imadenovec is a non-replicating adenoviral vector–based immunotherapy that expresses a fusion antigen from selected regions of HPV-6/11 proteins to elicit an immune response in RRP.

    Synonyms: DNA (recombinant replication-deficient Gorilla gorilla gorilla adenovirus strain GC4 vector PRGN-2012 human cytomegalovirus promoter plus human papillomavirus 6/11 E2, E4, E6, E7 protein 11 epitope-containing, Replication-deficient gorilla adenovirus vector (strain GC46) encoding human papillomavirus (HPV) type 6 and type 11 antigens comprising 11 epitopes derived from regions of the E2, E4, E6, and E7 proteinsCategories: Adeno-associated Viral Vector Therapies
  9. Drug

    Nadofaragene firadenovec

    go.drugbank.com/drugs/DB17381
    ApprovedInvestigational

    Nadofaragene firadenovec (nadofaragene firadenovec-vncg) is a recombinant non-replicating adenovirus serotype 5 vector containing a transgene encoding human interferon alfa-2b (IFNα2b).

    Synonyms: Replication-deficient adenovirus type 5 (ad5) vector encoding the human interferon alpha 2 (ifna2, interferon alpha-2b) gene under the control of the cytomegalovirus (cmv) immediate-early enhancer/promoterCategories: Adeno-associated Viral Vector Therapies
  10. Drug

    RGX-121

    go.drugbank.com/drugs/DB17681
    Investigational

    RGX-121 is designed to use the NAV AAV9 vector to deliver the human iduronate-2-sulfatase gene to the central nervous system.

    Synonyms: Non-replicating recombinant adeno-associated virus (AAV) vector of serotype 9 expressing human iduronate-2-sulfatase