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Displaying results 491 - 500 of 1804 in total
  1. Target

    Apolipoprotein B receptor

    go.drugbank.com/bio_entities/BE0005852
    TargetTransporterHumans

    Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL

    Polypeptides: Apolipoprotein B receptorSynonyms: Apolipoprotein B-100 receptor, Apolipoprotein B-48 receptor
  2. Target

    Melanocortin receptor 4

    go.drugbank.com/bio_entities/BE0009682
    TargetHumans

    G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha- and beta-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:12646665, PubMed:14764818, PubMed … Modulates the firing activity of neurons in paraventricular nucleus (PVN) of the hypothalamus via alpha-MSH and AGRP regulation of inwardly rectifying potassium channel KCNJ13 closure, independently of

    Polypeptides: Melanocortin receptor 4Function: corticotropin receptor activity
  3. Target

    Prosaposin receptor GPR37

    go.drugbank.com/bio_entities/BE0011479
    TargetHumans

    Additionally, extracellular vesicles derived from efferocyte express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor TIM4 via an ERK-AP1-dependent signaling … Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1.

    Polypeptides: Prosaposin receptor GPR37Synonyms: Parkin-associated endothelin receptor-like receptor, G protein-coupled receptor 37
  4. Target

    Relaxin receptor 1

    go.drugbank.com/bio_entities/BE0019700
    TargetHumans

    Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP.

    Polypeptides: Relaxin receptor 1Synonyms: Leucine-rich repeat-containing G protein-coupled receptor 7, Relaxin family peptide receptor 1
  5. Target

    Urotensin-2 receptor

    go.drugbank.com/bio_entities/BE0020904
    TargetHumans

    G protein-coupled receptor for the vasoactive neuropeptides urotensin-2 and urotensin-2B (PubMed:14550283). … Upon ligand binding, activates intracellular signaling cascades via G protein coupling, primarily through Gq/11, leading to phospholipase C activation, increased intracellular calcium, and activation of

    Polypeptides: Urotensin-2 receptorSynonyms: Urotensin II receptor, G protein-coupled receptor 14
  6. Drug

    Defibrotide

    go.drugbank.com/drugs/DB04932
    ApprovedInvestigational

    Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated s...

  7. Drug

    Undecylenic acid

    go.drugbank.com/drugs/DB11117
    Approved

    Undecylenic acid was first isolated from the products of distillation of castor oil in 1877 via pyrolysis of ricinoleic acid, and has been polymerized for vinyl production [A32281].

    Mixtures: TALCO VIDA SANA, TALCO VIDA SANA
  8. Drug

    Iluzanebart

    go.drugbank.com/drugs/DB18275
    Investigational

    Synonyms: Immunoglobulin G1 [296-cysteine,301-glycine,306-cysteine], anti-(human triggering receptor expressed on myeloid cells 2) (human monoclonal VGL101 γ1-chain), disulfide with human monoclonal VGL101 κ-chain
  9. Drug

    Eucalyptol

    go.drugbank.com/drugs/DB03852
    ApprovedInvestigationalNutraceutical

    It controls airway mucus hypersecretion and asthma via anti-inflammatory cytokine inhibition. Eucalyptol is an effective treatment for nonpurulent rhinosinusitis.

    Mixtures: POMADA VILA
  10. Drug

    Fazpilodemab

    go.drugbank.com/drugs/DB18924
    Investigational

    Fazpilodemab is under investigation in clinical trial NCT04171765 (A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of BFKB8488A Compared With Placebo in Participants With Non-alcoholic Steatohepatitis).

    Synonyms: immunoglobulin G1-kappa, anti-[Homo sapiens KLB (klotho beta, b-Klotho)] and anti-[Homo sapiens FGFR1 (fibroblast growth factor receptor 1, FLT2, KAL2)], monoclonal antibody, bispecific; gamma1 heavy chain