Search
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A
go.drugbank.com/bio_entities/BE0000706TargetHumansHydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:19350606, PubMed:8389765, PubMed:9195912). May have a role in muscle signal transduction (PubMed:9195912)
Polypeptides: High affinity 3',5'-cyclic-AMP phosphodiesterase 7AFunction: 3',5'-cyclic-AMP phosphodiesterase activityMitogen-activated protein kinase kinase kinase kinase 5
go.drugbank.com/bio_entities/BE0009474TargetHumansMay play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway
Polypeptides: Mitogen-activated protein kinase kinase kinase kinase 5Synonyms: MEKKK 5, MEK kinase kinase 5Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
go.drugbank.com/bio_entities/BE0014411TargetHumansAlso has 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang (PubMed:11863428). … Unwinds some G-quadruplex DNA (d(CGG)n tracts); unwinding seems to occur in both 5'-3' and 3'-5' direction and requires a short single-stranded tail (PubMed:10212265). d(CGG)n tracts have a propensity
Polypeptides: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRNFunction: 3'-5' DNA helicase activityTetrachlorodecaoxide
go.drugbank.com/drugs/DB05389ApprovedThe trial is being conducted in Germany at the University of Heidelberg and the National Centre for Tumor Diseases. … The Corporation believes the research to-date demonstrates that WF10 acts on macrophages (a type of white blood cell) by modulating the balance between inflammation and phagocytosis, a state in which the
Categories: Compounds used in a research, industrial, or household settingProducts: IMMUNOKINE (WF 10 I.V. SOLUTION)Pacritinib
go.drugbank.com/drugs/DB11697ApprovedInvestigationalof both primary and secondary MF in patients with platelet counts < 50 x 10<sup>9</sup>/L. … [L40793] Approximately 50% of patients with primary MF have a mutation of the _JAK2_ gene, which is also commonly mutated in patients with polycythemia vera or essential thrombocythemia.
Categories: Heterocyclic Compounds, 1-Ring, Janus Kinase 2, antagonists & inhibitorsDe Novo Triacylglycerol Biosynthesis TG(21:0/10:0/10:0)
smpdb.ca/view/SMP0026300MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(22:0/10:0/10:0)
smpdb.ca/view/SMP0026577MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(10:0/10:0/17:0)
smpdb.ca/view/SMP0026698MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(10:0/10:0/14:0)
smpdb.ca/view/SMP0026708MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...
De Novo Triacylglycerol Biosynthesis TG(10:0/10:0/13:0)
smpdb.ca/view/SMP0026719MetabolicA triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. Triglycerides are the main constituents of body fat in humans and other animals, as well as vegetable fat. They are a...